Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

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Fältnamn	Indikatorer	Metadata
000		08400naa a2201885 4500
001		oai:DiVA.org:umu-151046
003		SwePub
008		180905s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:1047e608-12e3-4f81-a538-f28059dbd862
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1510462 URI
024	7	a https://doi.org/10.1038/s41467-018-05074-y2 DOI
024	7	a https://lup.lub.lu.se/record/1047e608-12e3-4f81-a538-f28059dbd8622 URI
040		a (SwePub)umud (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Ji, Xuemeiu Dartmouth College4 aut
245	1 0	a Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk
264		c 2018-08-13
264	1	b NATURE PUBLISHING GROUP,c 2018
338		a electronic2 rdacarrier
520		a Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
700	1	a Bosse, Yohan4 aut
700	1	a Landi, Maria Teresa4 aut
700	1	a Gui, Jiang4 aut
700	1	a Xiao, Xiangjun4 aut
700	1	a Qian, David4 aut
700	1	a Joubert, Philippe4 aut
700	1	a Lamontagne, Maxime4 aut
700	1	a Li, Yafang4 aut
700	1	a Gorlov, Ivan4 aut
700	1	a de Biasi, Mariella4 aut
700	1	a Han, Younghun4 aut
700	1	a Gorlova, Olga4 aut
700	1	a Hung, Rayjean J.4 aut
700	1	a Wu, Xifeng4 aut
700	1	a Mckay, James4 aut
700	1	a Zong, Xuchen4 aut
700	1	a Carreras-Torres, Robert4 aut
700	1	a Christiani, David C.4 aut
700	1	a Caporaso, Neil4 aut
700	1	a Johansson, Mattias4 aut
700	1	a Liu, Geoffrey4 aut
700	1	a Bojesen, Stig E.4 aut
700	1	a Le Marchand, Loic4 aut
700	1	a Albanes, Demetrios4 aut
700	1	a Bickeboeller, Heike4 aut
700	1	a Aldrich, Melinda C.4 aut
700	1	a Bush, William S.4 aut
700	1	a Tardon, Adonina4 aut
700	1	a Rennert, Gad4 aut
700	1	a Chen, Chu4 aut
700	1	a Teare, M. Dawn4 aut
700	1	a Field, John K.4 aut
700	1	a Kiemeney, Lambertus A.4 aut
700	1	a Lazarus, Philip4 aut
700	1	a Haugen, Aage4 aut
700	1	a Lam, Stephen4 aut
700	1	a Schabath, Matthew B.4 aut
700	1	a Andrew, Angeline S.4 aut
700	1	a Shen, Hongbing4 aut
700	1	a Hong, Yun-Chul4 aut
700	1	a Yuan, Jian-Min4 aut
700	1	a Bertazzi, Pier A.4 aut
700	1	a Pesatori, Angela C.4 aut
700	1	a Ye, Yuanqing4 aut
700	1	a Diao, Nancy4 aut
700	1	a Su, Li4 aut
700	1	a Zhang, Ruyang4 aut
700	1	a Brhane, Yonathan4 aut
700	1	a Leighl, Natasha4 aut
700	1	a Johansen, Jakob S.4 aut
700	1	a Mellemgaard, Anders4 aut
700	1	a Saliba, Walid4 aut
700	1	a Haiman, Christopher4 aut
700	1	a Wilkens, Lynne4 aut
700	1	a Fernandez-Somoano, Ana4 aut
700	1	a Fernandez-Tardon, Guillermo4 aut
700	1	a van der Heijden, Erik H. F. M.4 aut
700	1	a Kim, Jin Hee4 aut
700	1	a Dai, Juncheng4 aut
700	1	a Hu, Zhibin4 aut
700	1	a Davies, Michael P. A.4 aut
700	1	a Marcus, Michael W.4 aut
700	1	a Brunnström, Hansu Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups4 aut0 (Swepub:lu)med-hsb
700	1	a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)smi-jma
700	1	a Melander, Olleu Lund University,Lunds universitet4 aut0 (Swepub:lu)endo-ome
700	1	a Muller, David C.4 aut
700	1	a Overvad, Kimu Lund University4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Doherty, Jennifer4 aut
700	1	a Goodman, Gary E.4 aut
700	1	a Cox, Angela4 aut
700	1	a Taylor, Fiona4 aut
700	1	a Woll, Penella4 aut
700	1	a Brueske, Irene4 aut
700	1	a Manz, Judith4 aut
700	1	a Muley, Thomas4 aut
700	1	a Risch, Angela4 aut
700	1	a Rosenberger, Albert4 aut
700	1	a Grankvist, Kjellu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002
700	1	a Johansson, Mikaelu Umeå universitet,Onkologi4 aut0 (Swepub:umu)mijo0025
700	1	a Shepherd, Frances4 aut
700	1	a Tsao, Ming-Sound4 aut
700	1	a Arnold, Susanne M.4 aut
700	1	a Haura, Eric B.4 aut
700	1	a Bolca, Ciprian4 aut
700	1	a Holcatova, Ivana4 aut
700	1	a Janout, Vladimir4 aut
700	1	a Kontic, Milica4 aut
700	1	a Lissowska, Jolanta4 aut
700	1	a Mukeria, Anush4 aut
700	1	a Ognjanovic, Simona4 aut
700	1	a Orlowski, Tadeusz M.4 aut
700	1	a Scelo, Ghislaine4 aut
700	1	a Swiatkowska, Beata4 aut
700	1	a Zaridze, David4 aut
700	1	a Bakke, Per4 aut
700	1	a Skaug, Vidar4 aut
700	1	a Zienolddiny, Shanbeh4 aut
700	1	a Duell, Eric J.4 aut
700	1	a Butler, Lesley M.4 aut
700	1	a Koh, Woon-Puay4 aut
700	1	a Gao, Yu-Tang4 aut
700	1	a Houlston, Richard4 aut
700	1	a McLaughlin, John4 aut
700	1	a Stevens, Victoria4 aut
700	1	a Nickle, David C.4 aut
700	1	a Obeidat, Ma'en4 aut
700	1	a Timens, Wim4 aut
700	1	a Zhu, Bin4 aut
700	1	a Song, Lei4 aut
700	1	a Artigas, Maria Soler4 aut
700	1	a Tobin, Martin D.4 aut
700	1	a Wain, Louise V.4 aut
700	1	a Gu, Fangyi4 aut
700	1	a Byun, Jinyoung4 aut
700	1	a Kamal, Ahsan4 aut
700	1	a Zhu, Dakai4 aut
700	1	a Tyndale, Rachel F.4 aut
700	1	a Wei, Wei-Qi4 aut
700	1	a Chanock, Stephen4 aut
700	1	a Brennan, Paul4 aut
700	1	a Amos, Christopher I.u Dartmouth College4 aut
710	2	a Dartmouth Collegeb Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga4 org
710	2	a et al.
773	0	t Nature Communicationsd : NATURE PUBLISHING GROUPg 9, s. 1-15q 9<1-15x 2041-1723
856	4	u https://doi.org/10.1038/s41467-018-05074-yy Fulltext
856	4	u https://umu.diva-portal.org/smash/get/diva2:1245321/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://www.nature.com/articles/s41467-018-05074-y.pdf
856	4	u http://dx.doi.org/10.1038/s41467-018-05074-yx freey FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-151046
856	4 8	u https://doi.org/10.1038/s41467-018-05074-y
856	4 8	u https://lup.lub.lu.se/record/1047e608-12e3-4f81-a538-f28059dbd862

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Av författaren/redakt...: Ji, Xuemei; Bosse, Yohan; Landi, Maria Ter ...; Gui, Jiang; Xiao, Xiangjun; Qian, David; visa fler...; Joubert, Philipp ...; Lamontagne, Maxi ...; Li, Yafang; Gorlov, Ivan; de Biasi, Mariel ...; Han, Younghun; Gorlova, Olga; Hung, Rayjean J.; Wu, Xifeng; Mckay, James; Zong, Xuchen; Carreras-Torres, ...; Christiani, Davi ...; Caporaso, Neil; Johansson, Matti ...; Liu, Geoffrey; Bojesen, Stig E.; Le Marchand, Loi ...; Albanes, Demetri ...; Bickeboeller, He ...; Aldrich, Melinda ...; Bush, William S.; Tardon, Adonina; Rennert, Gad; Chen, Chu; Teare, M. Dawn; Field, John K.; Kiemeney, Lamber ...; Lazarus, Philip; Haugen, Aage; Lam, Stephen; Schabath, Matthe ...; Andrew, Angeline ...; Shen, Hongbing; Hong, Yun-Chul; Yuan, Jian-Min; Bertazzi, Pier A ...; Pesatori, Angela ...; Ye, Yuanqing; Diao, Nancy; Su, Li; Zhang, Ruyang; Brhane, Yonathan; Leighl, Natasha; Johansen, Jakob ...; Mellemgaard, And ...; Saliba, Walid; Haiman, Christop ...; Wilkens, Lynne; Fernandez-Somoan ...; Fernandez-Tardon ...; van der Heijden, ...; Kim, Jin Hee; Dai, Juncheng; Hu, Zhibin; Davies, Michael ...; Marcus, Michael ...; Brunnström, Hans; Manjer, Jonas; Melander, Olle; Muller, David C.; Overvad, Kim; Trichopoulou, An ...; Tumino, Rosario; Doherty, Jennife ...; Goodman, Gary E.; Cox, Angela; Taylor, Fiona; Woll, Penella; Brueske, Irene; Manz, Judith; Muley, Thomas; Risch, Angela; Rosenberger, Alb ...; Grankvist, Kjell; Johansson, Mikae ...; Shepherd, France ...; Tsao, Ming-Sound; Arnold, Susanne ...; Haura, Eric B.; Bolca, Ciprian; Holcatova, Ivana; Janout, Vladimir; Kontic, Milica; Lissowska, Jolan ...; Mukeria, Anush; Ognjanovic, Simo ...; Orlowski, Tadeus ...; Scelo, Ghislaine; Swiatkowska, Bea ...; Zaridze, David; Bakke, Per; Skaug, Vidar; Zienolddiny, Sha ...; Duell, Eric J.; Butler, Lesley M ...; Koh, Woon-Puay; Gao, Yu-Tang; Houlston, Richar ...; McLaughlin, John; Stevens, Victori ...; Nickle, David C.; Obeidat, Ma'en; Timens, Wim; Zhu, Bin; Song, Lei; Artigas, Maria S ...; Tobin, Martin D.; Wain, Louise V.; Gu, Fangyi; Byun, Jinyoung; Kamal, Ahsan; Zhu, Dakai; Tyndale, Rachel ...; Wei, Wei-Qi; Chanock, Stephen; Brennan, Paul; Amos, Christophe ...; visa färre...

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