Sökning: onr:"swepub:oai:DiVA.org:umu-151134" > HLA and KIR Associa...
Fältnamn | Indikatorer | Metadata |
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000 | 07022naa a2200889 4500 | |
001 | oai:DiVA.org:umu-151134 | |
003 | SwePub | |
008 | 180828s2018 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:05e4559f-ae73-4504-898d-69a15b8424a4 | |
009 | oai:gup.ub.gu.se/273945 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1511342 URI |
024 | 7 | a https://doi.org/10.1093/infdis/jiy4832 DOI |
024 | 7 | a https://lup.lub.lu.se/record/05e4559f-ae73-4504-898d-69a15b8424a42 URI |
024 | 7 | a https://gup.ub.gu.se/publication/2739452 URI |
040 | a (SwePub)umud (SwePub)lud (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Pettersson-Kymmer, Ulrikau Umeå University,Umeå universitet,Farmakologi,Näringsforskning4 aut0 (Swepub:umu)ulpe0007 |
245 | 1 0 | a HLA and KIR Associations of Cervical Neoplasia |
264 | c 2018-08-07 | |
264 | 1 | b Oxford University Press,c 2018 |
338 | a print2 rdacarrier | |
520 | a Background: Cervical cancer is the fourth most common cancer in women, and we recently reported human leukocyte antigen (HLA) alleles showing strong associations with cervical neoplasia risk and protection. HLA ligands are recognised by killer immunoglobulin-like receptors (KIRs) expressed on a range of immune cell subsets, governing their proinflammatory activity. We hypothesized that the inheritance of particular HLA-KIR combinations would increase cervical neoplasia risk.Methods: Here, we used HLA and KIR dosages imputed from SNP genotype data from 2,143 cervical neoplasia cases and 13,858 healthy controls of European decent.Results: Four novel HLA alleles were identified in association with cervical neoplasia: HLA-DRB3*9901 (OR=1.24, P=2.49×10-9), HLA-DRB5*0101 (OR=1.29, P=2.26×10-8), HLA-DRB5*9901 (OR=0.77, P=1.90×10-9) and HLA-DRB3*0301 (OR=0.63, P=4.06×10-5), due to their linkage disequilibrium with known cervical neoplasia-associated HLA-DRB1 alleles. We also found homozygosity of HLA-C1 group alleles is a protective factor for HPV16-related cervical neoplasia (C1/C1, OR=0.79, P=0.005). This protective association was restricted to carriers of either KIR2DL2 (OR=0.67, P=0.00045) or KIR2DS2 (OR=0.69, P=0.0006).Conclusions: Our findings suggest that HLA-C1 group alleles play a role in protecting against HPV16-related cervical neoplasia, mainly through a KIR-mediated mechanism. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
653 | a Cervical neoplasia; human leukocyte antigens (HLA) | |
653 | a killer immunoglobulin-like receptors (KIRs) | |
653 | a HPV16-related cervical neoplasia | |
700 | 1 | a Hanson, Aimee Lu Princess Alexandra Hospital,University of Queensland4 aut |
700 | 1 | a Madeleine, Margaret Mu Fred Hutchinson Cancer Research Center,Queensland University of Technology,University of Melbourne,Murdoch Children's Research Institute4 aut |
700 | 1 | a Wang, Sophia Su City of Hope National Medical Center4 aut |
700 | 1 | a Schwartz, Stephen M4 aut |
700 | 1 | a Newell, Felicityu Queensland University of Technology4 aut |
700 | 1 | a Pettersson-Kymmer, Ulrika4 aut |
700 | 1 | a Hemminki, Kariu Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre4 aut0 (Swepub:lu)med-khk |
700 | 1 | a Tiews, Svenu MVZ Labor für Cytopathologie Dr. Steinberg GmbH4 aut |
700 | 1 | a Steinberg, Winfriedu MVZ Labor für Cytopathologie Dr. Steinberg GmbH4 aut |
700 | 1 | a Rader, Janet Su Medical College of Wisconsin4 aut |
700 | 1 | a Castro, Felipeu German Cancer Research Centre4 aut |
700 | 1 | a Safaeian, Mahboobehu National Cancer Institute, NCI4 aut |
700 | 1 | a Franco, Eduardo Lu McGill University4 aut |
700 | 1 | a Coutlée, Françoisu University Of Montreal Health Center (CRCHUM)4 aut |
700 | 1 | a Ohlsson, Claes,d 1965u Gothenburg University,Göteborgs universitet,University of Gothenburg,Centre for Bone and Arthritis Research,Institutionen för medicin,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xohlcl |
700 | 1 | a Cortes, Adrianu University of Queensland4 aut |
700 | 1 | a Marshall, Mhairi4 aut |
700 | 1 | a Mukhopadhyay, Pamelau University of Queensland4 aut |
700 | 1 | a Cremin, Katieu University of Queensland4 aut |
700 | 1 | a Johnson, Lisa Gu Fred Hutchinson Cancer Research Center4 aut |
700 | 1 | a Garland, Suzanne M4 aut |
700 | 1 | a Tabrizi, Sepehr Nu Murdoch Children's Research Institute,University of Melbourne4 aut |
700 | 1 | a Wentzensen, Nicolasu National Cancer Institute, NCI4 aut |
700 | 1 | a Sitas, Freddyu Cancer Council New South Wales,University of New South Wales,University of Sydney4 aut |
700 | 1 | a Trimble, Corneliau Johns Hopkins University4 aut |
700 | 1 | a Little, Julianu University of Ottawa4 aut |
700 | 1 | a Cruickshank, Maggieu University of Aberdeen4 aut |
700 | 1 | a Frazer, Ian Hu University of Queensland,Princess Alexandra Hospital4 aut |
700 | 1 | a Hildesheim, Allanu National Cancer Institute, NCI4 aut |
700 | 1 | a Brown, Matthew Au Queensland University of Technology4 aut |
700 | 1 | a Duncan, Emma Lu Queensland University of Technology4 aut |
700 | 1 | a Sun, YingPu4 aut |
700 | 1 | a Leo, Paul Ju Queensland University of Technology4 aut |
700 | 1 | a Bao, Xiaou First Affiliated Hospital of Zhengzhou University,Queensland University of Technology4 aut |
700 | 1 | a Sun, Ying Puu First Affiliated Hospital of Zhengzhou University4 aut |
710 | 2 | a Umeå universitetb Farmakologi4 org |
773 | 0 | t Journal of Infectious Diseasesd : Oxford University Pressg 218:12, s. 2006-2015q 218:12<2006-2015x 0022-1899x 1537-6613 |
856 | 4 | u https://academic.oup.com/jid/article-pdf/218/12/2006/26362864/jiy483.pdf |
856 | 4 | u http://dx.doi.org/10.1093/infdis/jiy483y FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-151134 |
856 | 4 8 | u https://doi.org/10.1093/infdis/jiy483 |
856 | 4 8 | u https://lup.lub.lu.se/record/05e4559f-ae73-4504-898d-69a15b8424a4 |
856 | 4 8 | u https://gup.ub.gu.se/publication/273945 |
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