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Sökning: onr:"swepub:oai:DiVA.org:umu-151284" > Neoadjuvant Chemoth...

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FältnamnIndikatorerMetadata
00006817naa a2200625 4500
001oai:DiVA.org:umu-151284
003SwePub
008180831s2018 | |||||||||||000 ||eng|
009oai:DiVA.org:uu-371038
009oai:DiVA.org:liu-153150
009oai:prod.swepub.kib.ki.se:139628883
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1512842 URI
0247 a https://doi.org/10.1016/j.eururo.2018.06.0482 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3710382 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1531502 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1396288832 URI
040 a (SwePub)umud (SwePub)uud (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Krantz, Davidu Karolinska Institutet4 aut
2451 0a Neoadjuvant Chemotherapy Reinforces Antitumour T cell Response in Urothelial Urinary Bladder Cancer
264 1b Elsevier,c 2018
338 a print2 rdacarrier
500 a Funding Agencies|Swedish Cancer Foundation; Wallenberg Foundation; Swedish Medical Research Council, Vinnova; Regionala forskningsradet in Uppsala-Orebroregionen (RFR in Uppsala-Orebro); Swedish Research Council; Cancer Research Foundation in Norrland, Umea, Sweden; Karolinska Research Network Program in Immune Modulatory Therapies for Autoimmunity and Cancer
520 a Evidence indicates that neoadjuvant chemotherapy (NAC) may promote antitumour immune responses by activating T cells. The tumour-draining sentinel node (SN) is a key site to study tumour-specific T cell activation, being the primary immunological barrier against the tumour. In this prospective study, we set out to elucidate the effects of NAC on T cell subsets in the SNs of patients with muscle-invasive urothelial bladder cancer. We found that CD8+ effector T (Teff) cell exhaustion was reduced after NAC treatment, while cytotoxicity was increased. Additionally, in complete responders (CR patients), these cells were functionally committed effectors, as displayed by epigenetic analysis. In CD4+ Teffs, NAC treatment was associated with increased clonal expansion of tumour-specific SN-derived cells, as demonstrated by a specific cell reactivity assay. In contrast, we observed an attenuating effect of NAC on regulatory T cells (Tregs) with a dose-dependent decrease in Treg frequency and reduced effector molecule expression in the remaining Tregs. In addition, multicolour flow cytometry analysis revealed that CR patients had higher Teff to activated Treg ratio, promoting antitumoural T cell activation. These results suggest that NAC reinforces the antitumour immune response by activating the effector arm of the T cell compartment and diminishing the influence of suppressive Tregs.PATIENT SUMMARY: In this report, we analysed the effect of chemotherapy on immune cell subsets of 40 patients with advanced bladder cancer. We found that chemotherapy has a positive effect on immune effector T cells, whereas an opposite, diminishing effect was observed for immune-suppressive regulatory T cells. We conclude that chemotherapy reinforces the antitumour immune response in bladder cancer patients.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Chemotherapy
653 a Sentinel node
653 a T cells
653 a Urothelial bladder cancer
7001 a Hartana, Ciputra Adijayau Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden4 aut
7001 a Winerdal, Malin Eu Karolinska Institutet4 aut
7001 a Johansson, Markusu Umeå universitet,Urologi och andrologi,Department of Urology, Sundsvall Hospital, Sundsvall, Sweden,Sundsvall Hosp, Dept Urol, Sundsvall, Sweden;Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden4 aut
7001 a Alamdari, Farhoodu Vastmanland Hosp, Dept Urol, Vasteras, Sweden4 aut
7001 a Jakubczyk, Tomaszu Ryhov Cty Hosp, Dept Urol, Jonkoping, Sweden4 aut
7001 a Huge, Ylvau Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland4 aut0 (Swepub:liu)ylvhu61
7001 a Aljabery, Firasu Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland4 aut0 (Swepub:liu)firab05
7001 a Palmqvist, Karinu Umeå universitet,Urologi och andrologi,Urology Section, Department of Surgery, Östersund County Hospital, Östersund, Sweden,Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden;Ostersund Cty Hosp, Dept Surg, Urol Sect, Ostersund, Sweden4 aut
7001 a Zirakzadeh, A. Aliu Umeå universitet,Urologi och andrologi,Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden;Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden4 aut0 (Swepub:umu)alizih97
7001 a Holmström, Bennyu Uppsala universitet,Urologkirurgi,Akad Univ Hosp, Sweden4 aut
7001 a Riklund, Katrine,d 1963-u Umeå universitet,Diagnostisk radiologi,Umea Univ, Dept Radiat Sci, Diagnost Radiol, Umea, Sweden4 aut0 (Swepub:umu)kaah0001
7001 a Sherif, Amiru Linköpings universitet,Umeå universitet,Urologi och andrologi,Division of Urology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden,Umea Univ, Dept Surg & Perioperat Sci, Urol & Androl, Umea, Sweden;Linkoping Univ, Dept Clin & Expt Med, Div Urol, Linkoping, Sweden,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten4 aut0 (Swepub:liu)amish64
7001 a Winqvist, Olau Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden4 aut
7102 a Karolinska Institutetb Karolinska Inst, Dept Med Solna, Unit Immunol & Allergy, Stockholm, Sweden4 org
7730 t European Urologyd : Elsevierg 74:6, s. 688-692q 74:6<688-692x 0302-2838x 1873-7560
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-151284
8564 8u https://doi.org/10.1016/j.eururo.2018.06.048
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-371038
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-153150
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:139628883

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