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Blood Levels of Cad...
Blood Levels of Cadmium and Lead in Relation to Breast Cancer Risk in Three Prospective Cohorts.
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- Gaudet, Mia M (författare)
- American Cancer Society
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- Deubler, Emily L (författare)
- American Cancer Society
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- Kelly, Rachel S (författare)
- Brigham and Women's Hospital / Harvard Medical School
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- Diver, W Ryan (författare)
- American Cancer Society
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- Teras, Lauren R (författare)
- American Cancer Society
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- Hodge, James M (författare)
- American Cancer Society
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- Levine, Keith E (författare)
- RTI International
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- Haines, Laura G (författare)
- RTI International
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- Lundh, Thomas (författare)
- Lund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups
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- Lenner, Per (författare)
- Umeå University,Umeå universitet,Onkologi
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- Palli, Domenico (författare)
- Cancer Research and Prevention Institute (ISPO)
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- Vineis, Paolo (författare)
- Imperial College London
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- Bergdahl, Ingvar (författare)
- Umeå University,Umeå universitet,Yrkes- och miljömedicin,Enheten för biobanksforskning
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- Gapstur, Susan M (författare)
- American Cancer Society
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- Kyrtopoulos, Soterios A (författare)
- National Hellenic Research Foundation
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(creator_code:org_t)
- 2018-11-07
- 2019
- Engelska.
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Ingår i: International Journal of Cancer. - : Wiley-Blackwell. - 0020-7136 .- 1097-0215. ; 144:5, s. 1010-1016
- Relaterad länk:
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https://europepmc.or...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Cadmium and lead have been classified as carcinogens by the International Agency for Research on Cancer. However, their associations with breast cancer risk are unknown despite their persistence in the environment and ubiquitous human exposure. We examined associations of circulating levels of cadmium and lead with breast cancer risk in three case-control studies nested within the Cancer Prevention Study-II (CPS-II) LifeLink Cohort, European Prospective Investigation into Cancer and Nutrition - Italy (EPIC-Italy), and the Northern Sweden Health and Disease Study (NSHDS) cohorts. Metal levels were measured in stored erythrocytes from 1,435 cases and 1,433 controls using inductively coupled plasma-mass spectrometry. Summary relative risks (RR) and 95% confidence intervals (CI) were calculated using random-effects models with each study result weighted by the within- and between-study variances. I2 values were calculated to estimate proportion of between study variation. Using common cut-points, cadmium levels were not associated with breast cancer risk in the CPS-II cohort (continuous RR=1.01, 95% CI 0.76 - 1.34), but were inversely associated with risk in the EPIC- Italy (continuous RR=0.80, 95% CI 0.61 - 1.03) and NSHDS cohorts (continuous RR=0.73, 95% CI 0.54 - 0.97). The inverse association was also evident in the meta-analysis (continuous RR=0.84, 95% CI 0.69 - 1.01) with low between-study heterogeneity. Large differences in lead level distributions precluded a meta-analysis of their association with breast cancer risk; no associations were found in the three studies. Adult cadmium and lead levels were not associated with higher risk of breast cancer in our large meta-analysis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- breast cancer
- cadmium
- lead
- breast cancer
- cadmium
- lead
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Gaudet, Mia M
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Deubler, Emily L
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Kelly, Rachel S
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Diver, W Ryan
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Teras, Lauren R
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Hodge, James M
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visa fler...
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Levine, Keith E
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Haines, Laura G
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Lundh, Thomas
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Lenner, Per
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Palli, Domenico
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Vineis, Paolo
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Bergdahl, Ingvar
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Gapstur, Susan M
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Kyrtopoulos, Sot ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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International Jo ...
- Av lärosätet
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Umeå universitet
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Lunds universitet