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Blood Levels of Cad...
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Gaudet, Mia MAmerican Cancer Society
(författare)
Blood Levels of Cadmium and Lead in Relation to Breast Cancer Risk in Three Prospective Cohorts.
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2018-11-07
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Wiley-Blackwell,2019
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-152113
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-152113URI
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https://doi.org/10.1002/ijc.31805DOI
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https://lup.lub.lu.se/record/ea5fa34e-d329-494a-99f2-20cd01768408URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Cadmium and lead have been classified as carcinogens by the International Agency for Research on Cancer. However, their associations with breast cancer risk are unknown despite their persistence in the environment and ubiquitous human exposure. We examined associations of circulating levels of cadmium and lead with breast cancer risk in three case-control studies nested within the Cancer Prevention Study-II (CPS-II) LifeLink Cohort, European Prospective Investigation into Cancer and Nutrition - Italy (EPIC-Italy), and the Northern Sweden Health and Disease Study (NSHDS) cohorts. Metal levels were measured in stored erythrocytes from 1,435 cases and 1,433 controls using inductively coupled plasma-mass spectrometry. Summary relative risks (RR) and 95% confidence intervals (CI) were calculated using random-effects models with each study result weighted by the within- and between-study variances. I2 values were calculated to estimate proportion of between study variation. Using common cut-points, cadmium levels were not associated with breast cancer risk in the CPS-II cohort (continuous RR=1.01, 95% CI 0.76 - 1.34), but were inversely associated with risk in the EPIC- Italy (continuous RR=0.80, 95% CI 0.61 - 1.03) and NSHDS cohorts (continuous RR=0.73, 95% CI 0.54 - 0.97). The inverse association was also evident in the meta-analysis (continuous RR=0.84, 95% CI 0.69 - 1.01) with low between-study heterogeneity. Large differences in lead level distributions precluded a meta-analysis of their association with breast cancer risk; no associations were found in the three studies. Adult cadmium and lead levels were not associated with higher risk of breast cancer in our large meta-analysis.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Deubler, Emily LAmerican Cancer Society
(författare)
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Kelly, Rachel SBrigham and Women's Hospital / Harvard Medical School
(författare)
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Diver, W RyanAmerican Cancer Society
(författare)
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Teras, Lauren RAmerican Cancer Society
(författare)
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Hodge, James MAmerican Cancer Society
(författare)
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Levine, Keith ERTI International
(författare)
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Haines, Laura GRTI International
(författare)
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Lundh, ThomasLund University,Lunds universitet,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,Genetic Occupational and Environmental Medicine,Lund University Research Groups(Swepub:lu)ymed-tlu
(författare)
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Lenner, PerUmeå University,Umeå universitet,Onkologi(Swepub:umu)pele0005
(författare)
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Palli, DomenicoCancer Research and Prevention Institute (ISPO)
(författare)
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Vineis, PaoloImperial College London
(författare)
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Bergdahl, IngvarUmeå University,Umeå universitet,Yrkes- och miljömedicin,Enheten för biobanksforskning(Swepub:lu)extLU-1518
(författare)
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Gapstur, Susan MAmerican Cancer Society
(författare)
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Kyrtopoulos, Soterios ANational Hellenic Research Foundation
(författare)
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American Cancer SocietyBrigham and Women's Hospital / Harvard Medical School
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Cancer: Wiley-Blackwell144:5, s. 1010-10160020-71361097-0215
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Gaudet, Mia M
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Deubler, Emily L
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Kelly, Rachel S
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Diver, W Ryan
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Teras, Lauren R
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Hodge, James M
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visa fler...
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Levine, Keith E
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Haines, Laura G
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Lundh, Thomas
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Lenner, Per
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Palli, Domenico
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Vineis, Paolo
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Bergdahl, Ingvar
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Gapstur, Susan M
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Kyrtopoulos, Sot ...
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