SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:umu-154577"
 

Sökning: onr:"swepub:oai:DiVA.org:umu-154577" > Methodological issu...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007427naa a2201093 4500
001oai:DiVA.org:umu-154577
003SwePub
008181219s2019 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:140300841
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1545772 URI
0247 a https://doi.org/10.1016/j.envres.2018.11.0272 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1403008412 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Gasull, Magda4 aut
2451 0a Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort
264 1b Elsevier,c 2019
338 a print2 rdacarrier
520 a BACKGROUND: The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases.OBJECTIVES: First, to summarize the main design features of a prospective case-control study -nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort- on plasma concentrations of persistent organic pollutants (POPs) and pancreatic cancer risk. And second, to assess the main methodological challenges posed by associations among characteristics and habits of study participants, fasting status, time from blood draw to cancer diagnosis, disease progression bias, basis of cancer diagnosis, and plasma concentrations of lipids and POPs. Results from etiologic analyses on POPs and pancreatic cancer risk, and other analyses, will be reported in future articles.METHODS: Study subjects were 1533 participants (513 cases and 1020 controls matched by study centre, sex, age at blood collection, date and time of blood collection, and fasting status) enrolled between 1992 and 2000. Plasma concentrations of 22 POPs were measured by gas chromatography - triple quadrupole mass spectrometry (GC-MS/MS). To estimate the magnitude of the associations we calculated multivariate-adjusted odds ratios by unconditional logistic regression, and adjusted geometric means by General Linear Regression Models.RESULTS: There were differences among countries in subjects' characteristics (as age, gender, smoking, lipid and POP concentrations), and in study characteristics (as time from blood collection to index date, year of last follow-up, length of follow-up, basis of cancer diagnosis, and fasting status). Adjusting for centre and time of blood collection, no factors were significantly associated with fasting status. Plasma concentrations of lipids were related to age, body mass index, fasting, country, and smoking. We detected and quantified 16 of the 22 POPs in more than 90% of individuals. All 22 POPs were detected in some participants, and the smallest number of POPs detected in one person was 15 (median, 19) with few differences by country. The highest concentrations were found for p,p'-DDE, PCBs 153 and 180 (median concentration: 3371, 1023, and 810 pg/mL, respectively). We assessed the possible occurrence of disease progression bias (DPB) in eight situations defined by lipid and POP measurements, on one hand, and by four factors: interval from blood draw to index date, tumour subsite, tumour stage, and grade of differentiation, on the other. In seven of the eight situations results supported the absence of DPB.CONCLUSIONS: The coexistence of differences across study centres in some design features and participant characteristics is of relevance to other multicentre studies. Relationships among subjects' characteristics and among such characteristics and design features may play important roles in the forthcoming analyses on the association between plasma concentrations of POPs and pancreatic cancer risk.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
653 a Biomarkers
653 a methods
653 a Disease progression bias
653 a Environmental epidemiology
653 a Lipids
653 a Pancreatic cancer
653 a Persistent organic pollutants
7001 a Pumarega, José4 aut
7001 a Kiviranta, Hannu4 aut
7001 a Rantakokko, Panu4 aut
7001 a Raaschou-Nielsen, Ole4 aut
7001 a Bergdahl, Ingvar A.u Umeå universitet,Yrkes- och miljömedicin,Enheten för biobanksforskning4 aut0 (Swepub:umu)inbe0001
7001 a Sandanger, Torkjel Manning4 aut
7001 a Goñi, Fernando4 aut
7001 a Cirera, Lluís4 aut
7001 a Donat-Vargas, Carolinau Karolinska Institutet4 aut
7001 a Alguacil, Juan4 aut
7001 a Iglesias, Mar4 aut
7001 a Tjønneland, Anne4 aut
7001 a Overvad, Kim4 aut
7001 a Mancini, Francesca Romana4 aut
7001 a Boutron-Ruault, Marie-Christine4 aut
7001 a Severi, Gianluca4 aut
7001 a Johnson, Theron4 aut
7001 a Kühn, Tilman4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Karakatsani, Anna4 aut
7001 a Peppa, Eleni4 aut
7001 a Palli, Domenico4 aut
7001 a Pala, Valeria4 aut
7001 a Tumino, Rosario4 aut
7001 a Naccarati, Alessio4 aut
7001 a Panico, Salvatore4 aut
7001 a Verschuren, Monique4 aut
7001 a Vermeulen, Roel4 aut
7001 a Rylander, Charlotta4 aut
7001 a Haugdahl Nøst, Therese4 aut
7001 a Rodríguez-Barranco, Miguel4 aut
7001 a Molinuevo, Amaia4 aut
7001 a Chirlaque, María-Dolores4 aut
7001 a Ardanaz, Eva4 aut
7001 a Sund, Malinu Umeå universitet,Kirurgi,Sund4 aut0 (Swepub:umu)masu0021
7001 a Key, Tim4 aut
7001 a Ye, Weiminu Karolinska Institutet,Umeå universitet,Enheten för biobanksforskning,Department of Medical Epidemiology and Biostatistics Karolinska Institutet, Stockholm, Sweden4 aut
7001 a Jenab, Mazda4 aut
7001 a Michaud, Dominique4 aut
7001 a Matullo, Giuseppe4 aut
7001 a Canzian, Federico4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Nieters, Alexandra4 aut
7001 a Nöthlings, Ute4 aut
7001 a Jeurnink, Suzanne4 aut
7001 a Chajes, Veronique4 aut
7001 a Matejcic, Marco4 aut
7001 a Gunter, Marc4 aut
7001 a Aune, Dagfinn4 aut
7001 a Riboli, Elio4 aut
7001 a Agudo, Antoni4 aut
7001 a Gonzalez, Carlos Alberto4 aut
7001 a Weiderpass, Elisabeteu Karolinska Institutet4 aut
7001 a Bueno-de-Mesquita, Bas4 aut
7001 a Duell, Eric J.4 aut
7001 a Vineis, Paolo4 aut
7001 a Porta, Miquel4 aut
7102 a Umeå universitetb Yrkes- och miljömedicin4 org
7730 t Environmental Researchd : Elsevierg 169, s. 417-433q 169<417-433x 0013-9351x 1096-0953
8564 u http://diposit.ub.edu/dspace/bitstream/2445/171688/1/GasullM.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-154577
8564 8u https://doi.org/10.1016/j.envres.2018.11.027
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:140300841

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy