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Dynamic contrast-en...
Dynamic contrast-enhanced magnetic resonance imaging may act as a biomarker for vascular damage in normal appearing brain tissue after radiotherapy in patients with glioblastoma
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- Fahlström, Markus (författare)
- Uppsala universitet,Radiologi
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- Fransson, Samuel (författare)
- Uppsala universitet,Radiologi
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- Blomquist, Erik (författare)
- Uppsala universitet,Experimentell och klinisk onkologi
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- Nyholm, Tufve (författare)
- Umeå universitet,Radiofysik
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- Larsson, Elna-Marie (författare)
- Uppsala universitet,Radiologi
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(creator_code:org_t)
- 2018-11-09
- 2018
- Engelska.
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Ingår i: Acta Radiologica Open. - : Sage Publications. - 2058-4601. ; 7:11
- Relaterad länk:
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https://doi.org/10.1...
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https://journals.sag...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
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- BackgroundDynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a promising perfusion method and may be useful in evaluating radiation-induced changes in normal-appearing brain tissue.PurposeTo assess whether radiotherapy induces changes in vascular permeability (Ktrans) and the fractional volume of the extravascular extracellular space (Ve) derived from DCE-MRI in normal-appearing brain tissue and possible relationships to radiation dose given.Material and MethodsSeventeen patients with glioblastoma treated with radiotherapy and chemotherapy were included; five were excluded because of inconsistencies in the radiotherapy protocol or early drop-out. DCE-MRI, contrast-enhanced three-dimensional (3D) T1-weighted (T1W) images and T2-weighted fluid attenuated inversion recovery (T2-FLAIR) images were acquired before and on average 3.3, 30.6, 101.6, and 185.7 days after radiotherapy. Pre-radiotherapy CE T1W and T2-FLAIR images were segmented into white and gray matter, excluding all non-healthy tissue. Ktrans and Ve were calculated using the extended Kety model with the Parker population-based arterial input function. Six radiation dose regions were created for each tissue type, based on each patient’s computed tomography-based dose plan. Mean Ktrans and Ve were calculated over each dose region and tissue type.ResultsGlobal Ktrans and Ve demonstrated mostly non-significant changes with mean values higher for post-radiotherapy examinations in both gray and white matter compared to pre-radiotherapy. No relationship to radiation dose was found.ConclusionAdditional studies are needed to validate if Ktrans and Ve derived from DCE-MRI may act as potential biomarkers for acute and early-delayed radiation-induced vascular damages. No dose-response relationship was found.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Nyckelord
- Dynamic contrast-enhanced magnetic resonance imaging
- DCE-MRI
- radiation therapy/oncology
- radiation effects
- normal-appearing brain tissue
- glioblastoma
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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