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Elevated serum high...
Elevated serum high-sensitivity cardiac troponin I is related to mortality in COPD
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- Nilsson, Ulf (författare)
- Umeå universitet,Kardiologi,Medicin
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- Blomberg, Anders, 1961- (författare)
- Umeå universitet,Medicin
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Mills, Nicholas (författare)
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- Rönmark, Eva (författare)
- Umeå universitet,Yrkes- och miljömedicin
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- Lindberg, Anne (författare)
- Umeå universitet,Medicin
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(creator_code:org_t)
- European Respiratory Society, 2018
- 2018
- Engelska.
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Ingår i: European Respiratory Journal. - : European Respiratory Society. - 0903-1936 .- 1399-3003. ; 52
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Cardiovascular diseases are the most common comorbid condition among subjects with COPD, but the predictive value of high-sensitivity cardiac troponin I (hs-cTnI) on prognosis has rarely been studied in population surveys.Aim: To assess the prevalence and impact of elevated serum hs-cTnI on mortality among subjects with COPD and normal lung function (NLF).Methods: In 2002-04, subjects with FEV1/VC <0.70 (COPD, n=993) and age- and sex-matched referents without COPD were identified from population-based cohorts. In 2005, structured interview, post-bronchodilator spirometry and blood sampling were performed in individuals with COPD (n=601) and referents (n=954), where 755 referents had NLF. Hs-cTnI was analysed in serum and values ≥5 ng/L were defined as elevated. Mortality data were collected until 2010.Results: The prevalence of elevated hs-cTnI was higher among COPD compared to NLF (31.1% vs. 24.9%, p=0.01). The 5-year cumulative mortality in individuals with elevated hs-cTnI was higher in COPD than in NLF (29.9% vs. 14.9%; p<0.001). In a cox-regression model adjusting for age, sex, pack-years and self-reported ischemic heart disease, elevated hs-cTnI was associated with an increased risk for death in COPD (HR 2.64, 95%CI 1.55-4.51), but not in those with NLF (HR 1.18, 95%CI 0.66-2.10). The increased risk in COPD remained after adjusting for disease severity.Conclusion: In this population-based study, elevated serum hs-cTnI concentrations were associated with increased risk for death among individuals with COPD, but not in those with NLF during a 5-year follow-up.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
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- art (ämneskategori)
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