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Identification of c...
Identification of candidate plasma protein biomarkers for cervical cancer using the multiplex proximity extension assay
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- Berggrund, Malin (författare)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab
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- Enroth, Stefan, 1976- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Lundberg, Martin (författare)
- OLINK Prote, Uppsala Sci Pk, SE-75183 Uppsala, Sweden
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- Assarsson, Erika (författare)
- OLINK Prote, Uppsala Sci Pk, SE-75183 Uppsala, Sweden
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- Stålberg, Karin (författare)
- Uppsala universitet,Reproduktiv hälsa
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- Lindquist, David (författare)
- Umeå universitet,Onkologi,Umeå Univ, Dept Radiat Sci, SE-90187 Umeå, Sweden
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- Hallmans, Göran, 1947- (författare)
- Umeå universitet,Näringsforskning,Umeå Univ, Dept Publ Hlth & Clin Med, Nutr Res, SE-90187 Umeå, Sweden
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- Grankvist, Kjell (författare)
- Umeå universitet,Klinisk kemi,Umeå Univ, Dept Med Biosci, Clin Chem, SE-90187 Umeå, Sweden
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- Olovsson, Matts, 1958- (författare)
- Uppsala universitet,Reproduktionsbiologi
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- Gyllensten, Ulf (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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(creator_code:org_t)
- 2019
- 2019
- Engelska.
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Ingår i: Molecular & Cellular Proteomics. - 1535-9476 .- 1535-9484. ; 18:4, s. 735-743
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Human papillomavirus (HPV) is recommended as the primary test in cervical cancer screening, with co-testing by cytology for HPV-positive women to identify cervical lesions. Cytology has low sensitivity and there is a need to identify biomarkers that could identify dysplasia that are likely to progress to cancer. We searched for plasma proteins that could identify women with cervical cancer using the multiplex proximity extension assay (PEA). The abundance of 100 proteins were measured in plasma collected at the time of diagnosis of patients with invasive cervical cancer and in population controls using the Olink Multiplex panels CVD II, INF I, and ONC II. Eighty proteins showed increased levels in cases compared to controls. We identified a signature of 11 proteins (PTX3, ITGB1BP2, AXIN1, STAMPB, SRC, SIRT2, 4E-BP1, PAPPA, HB-EGF, NEMO and IL27) that distinguished cases and controls with a sensitivity of 0.96 at a specificity of 1.0. This signature was evaluated in a prospective replication cohort with samples collected before, at or after diagnosis and achieved a sensitivity of 0.78 and a specificity 0.56 separating samples collected at the time of diagnosis of invasive cancer from samples collected prior to diagnosis. No difference in abundance was seen between samples collected prior to diagnosis or after treatment as compared to population controls, indicating that this protein signature is mainly informative close to time of diagnosis. Further studies are needed to determine the optimal window in time prior to diagnosis for these biomarker candidates.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Blood*
- Cancer biomarker(s)
- Cervical cancer
- Clinical proteomics
- Human Papillomavirus
- Personalized medicine
- Screening
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- Av författaren/redakt...
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Berggrund, Malin
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Enroth, Stefan, ...
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Lundberg, Martin
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Assarsson, Erika
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Stålberg, Karin
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Lindquist, David
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Hallmans, Göran, ...
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Grankvist, Kjell
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Olovsson, Matts, ...
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Gyllensten, Ulf
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biokemi och mole ...
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Molecular & Cell ...
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Umeå universitet
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Uppsala universitet