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B cell profiling in...
B cell profiling in malaria reveals expansion and remodeling of CD11c+ B cell subsets
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- Sundling, Christopher (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Ronnberg, Caroline (författare)
- Karolinska Institute,Karolinska University Hospital
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- Yman, Victor (författare)
- Karolinska Institutet,Karolinska Institute
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- Asghar, Muhammad (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Jahnmatz, Peter (författare)
- Karolinska Institutet,Karolinska Institute
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- Lakshmikanth, Tadepally (författare)
- Karolinska Institutet,Karolinska Institute
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- Chen, Yang (författare)
- Karolinska Institutet,Karolinska Institute
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- Mikes, Jaromir (författare)
- Karolinska Institutet,Karolinska Institute
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- Forsell, Mattias N. (författare)
- Umeå University,Umeå universitet,Institutionen för klinisk mikrobiologi
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- Sonden, Klara (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Achour, Adnane (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Brodin, Petter (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Persson, Kristina E.M. (författare)
- Karolinska Institute,Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Malaria och Babesia,Forskargrupper vid Lunds universitet,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Malaria and Babesia,Lund University Research Groups
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- Farnert, Anna (författare)
- Karolinska Institute,Karolinska University Hospital
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(creator_code:org_t)
- 2019-05-02
- 2019
- Engelska.
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Ingår i: JCI Insight. - : American Society for Clinical Investigation. - 2379-3708. ; 4:9
- Relaterad länk:
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http://insight.jci.o...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Humoral immunity is important in limiting clinical disease in malaria, yet the longitudinal B cell response to infection remains unclear. We performed a 1-year prospective study in patients treated for acute Plasmodium fakiporum malaria for the first time or with previous exposure to the disease. Using an unbiased exploratory approach with mass cytometry, followed by targeted flow cytometry, we found that approximately 80% of mature B cells that proliferated in response to acute infection expressed CD11c. Only approximately 40% of CD11c+ B cells displayed an atypical B cell phenotype, with the remaining cells primarily made up of activated and resting memory B cells. The CD11c+ B cells expanded rapidly following infection, with previous exposure to malaria resulting in a significantly larger increase compared with individuals with primary infection. This was attributed to an expansion of switched CD11c+ B cells that was absent in primary infected individuals. The rate of contraction of the CD11c+ B cell compartment was independent of previous exposure to malaria and displayed a slow decay, with a half-life of approximately 300 days. Collectively, these results identify CD11c as a marker of B cells responding to malaria and further highlight differences in primary and secondary B cell responses during infection.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Sundling, Christ ...
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Ronnberg, Caroli ...
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Yman, Victor
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Asghar, Muhammad
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Jahnmatz, Peter
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Lakshmikanth, Ta ...
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visa fler...
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Chen, Yang
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Mikes, Jaromir
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Forsell, Mattias ...
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Sonden, Klara
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Achour, Adnane
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Brodin, Petter
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Persson, Kristin ...
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Farnert, Anna
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Immunologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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JCI Insight
- Av lärosätet
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Umeå universitet
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Lunds universitet
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Karolinska Institutet