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Saliva and Serum Im...
Saliva and Serum Immune Responses in Apical Periodontitis
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- Pietiäinen, Milla (författare)
- University of Helsiki, Finland
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- Liljestrand, John M. (författare)
- University of Helsiki, Finland
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- Akhi, Ramin (författare)
- University of Oulu, Finland
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- Buhlin, Kåre (författare)
- Karolinska Institutet
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- Johansson, Anders, 1955- (författare)
- Umeå universitet,Institutionen för odontologi,Aa-gruppen
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- Paju, Susanna (författare)
- University of Helsinki, Finland
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- Salminen, Aino (författare)
- University of Helsinki Finland
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- Mäntylä, Päivi (författare)
- University of Kuopio, Finland
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- Sinisalo, Juha (författare)
- University of Kuopio, Finland
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- Tjäderhane, Leo (författare)
- University of Helsinki, Finland
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- Hörkkö, Sohvi (författare)
- University of Oulu, Finland
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- Pussinen, Pirkko J. (författare)
- University of Helsinki, Finland
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(creator_code:org_t)
- 2019-06-21
- 2019
- Engelska.
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Ingår i: Journal of Clinical Medicine. - Basel, Switzerland : MDPI. - 2077-0383. ; 8:6
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Apical periodontitis is an inflammatory reaction at the apex of an infected tooth. Its microbiota resembles that of marginal periodontitis and may induce local and systemic antibodies binding to bacteria- and host-derived epitopes. Our aim was to investigate the features of the adaptive immune response in apical periodontitis. The present Parogene cohort (n = 453) comprises patients with cardiac symptoms. Clinical and radiographic oral examination was performed to diagnose apical and marginal periodontitis. A three-category endodontic lesion score was designed. Antibodies binding to the bacteria- and host-derived epitopes were determined from saliva and serum, and bacterial compositions were examined from saliva and subgingival samples. The significant ORs (95% CI) for the highest endodontic scores were observed for saliva IgA and IgG to bacterial antigens (2.90 (1.01-8.33) and 4.91 (2.48-9.71)/log10 unit), saliva cross-reacting IgG (2.10 (1.48-2.97)), serum IgG to bacterial antigens (4.66 (1.22-10.1)), and Gram-negative subgingival species (1.98 (1.16-3.37)). In a subgroup without marginal periodontitis, only saliva IgG against bacterial antigens associated with untreated apical periodontitis (4.77 (1.05-21.7)). Apical periodontitis associates with versatile adaptive immune responses against both bacterial- and host-derived epitopes independently of marginal periodontitis. Saliva immunoglobulins could be useful biomarkers of oral infections including apical periodontitis-a putative risk factor for systemic diseases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- adaptive immunity
- antibody
- apical periodontitis
- saliva
- serum
- immunologi
- Immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Pietiäinen, Mill ...
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Liljestrand, Joh ...
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Akhi, Ramin
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Buhlin, Kåre
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Johansson, Ander ...
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Paju, Susanna
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visa fler...
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Salminen, Aino
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Mäntylä, Päivi
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Sinisalo, Juha
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Tjäderhane, Leo
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Hörkkö, Sohvi
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Pussinen, Pirkko ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Journal of Clini ...
- Av lärosätet
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Umeå universitet
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Karolinska Institutet