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Serum Metabolite Ma...
Serum Metabolite Markers of Dementia Through Quantitative NMR Analysis : The Importance of Threonine-Linked Metabolic Pathways
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- Figueira, Joao (författare)
- Umeå universitet,Klinisk neurovetenskap
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- Adolfsson, Rolf (författare)
- Umeå universitet,Psykiatri
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- Nordin Adolfsson, Annelie (författare)
- Umeå universitet,Psykiatri
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- Nyberg, Lars, 1966- (författare)
- Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB)
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- Öhman, Anders (författare)
- Umeå universitet,Klinisk neurovetenskap
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(creator_code:org_t)
- IOS Press, 2019
- 2019
- Engelska.
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Ingår i: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 69:3, s. 763-774
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- There is a great need for diagnostic biomarkers of impending dementia. Metabolite markers in blood have been investigated in several studies, but inconclusive findings encourage further investigation, particularly in the pre-diagnostic phase. In the present study, the serum metabolomes of 110 dementia or pre-diagnostic dementia individuals and 201 healthy individuals matched for age, gender, and education were analyzed by nuclear magnetic resonance spectroscopy in combination with multivariate data analysis. 58 metabolites were quantified in each of the 311 samples. Individuals with dementia were discriminated from controls using a panel of seven metabolites, while the pre-diagnostic dementia subjects were distinguished from controls using a separate set of seven metabolites, where threonine was a common significant metabolite in both panels. Metabolite and pathway alterations specific for dementia and pre-diagnostic dementia were identified, in particular a disturbed threonine catabolism at the pre-diagnostic stage that extends to several threonine-linked pathways at the dementia stage.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Alzheimer's disease
- biomarker
- dementia
- metabolomics/metabonomics
- NMR
- serum
- vascular dementia
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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