Sökning: onr:"swepub:oai:DiVA.org:umu-161892" > Staphylococcal alph...
Fältnamn | Indikatorer | Metadata |
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000 | 03547naa a2200565 4500 | |
001 | oai:DiVA.org:umu-161892 | |
003 | SwePub | |
008 | 190808s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1618922 URI |
024 | 7 | a https://doi.org/10.1080/2162402X.2019.16413872 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Blumel, Edda4 aut |
245 | 1 0 | a Staphylococcal alpha-toxin tilts the balance between malignant and non-malignant CD4+ T cells in cutaneous T-cell lymphoma |
264 | 1 | b Taylor & Francis,c 2019 |
338 | a electronic2 rdacarrier | |
520 | a Staphylococcus aureus is implicated in disease progression in cutaneous T-cell lymphoma (CTCL). Here, we demonstrate that malignant T cell lines derived from CTCL patients as well as primary malignant CD4+ T cells from Sézary syndrome patients are considerably more resistant to alpha-toxin-induced cell death than their non-malignant counterparts. Thus, in a subset of Sézary syndrome patients the ratio between malignant and non-malignant CD4+ T cells increases significantly following exposure to alpha-toxin. Whereas toxin-induced cell death is ADAM10 dependent in healthy CD4+ T cells, resistance to alpha-toxin in malignant T cells involves both downregulation of ADAM10 as well as other resistance mechanisms. In conclusion, we provide first evidence that Staphylococcus aureus derived alpha-toxin can tilt the balance between malignant and non-malignant CD4+ T cells in CTCL patients. Consequently, alpha-toxin may promote disease progression through positive selection of malignant CD4+ T cells, identifying alpha-toxin as a putative drug target in CTCL. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Cutaneous T-cell lymphoma | |
653 | a Staphylococcus aureus | |
653 | a alpha-toxin | |
653 | a disintegrin and metalloproteinase domain-containing protein 10 | |
700 | 1 | a Willerslev-Olsen, Andreas4 aut |
700 | 1 | a Gluud, Maria4 aut |
700 | 1 | a Lindahl, Lise M.4 aut |
700 | 1 | a Fredholm, Simon4 aut |
700 | 1 | a Nastasi, Claudia4 aut |
700 | 1 | a Krejsgaard, Thorbjorn4 aut |
700 | 1 | a Surewaard, Bas G. J.4 aut |
700 | 1 | a Koralov, Sergei B.4 aut |
700 | 1 | a Hu, Tengpeng4 aut |
700 | 1 | a Persson, Jenny L.u Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Clinical Research Center, Lund University, Sweden4 aut0 (Swepub:umu)jepe0128 |
700 | 1 | a Bonefeld, Charlotte Menne4 aut |
700 | 1 | a Geisler, Carsten4 aut |
700 | 1 | a Iversen, Lars4 aut |
700 | 1 | a Becker, Juergen C.4 aut |
700 | 1 | a Andersen, Mads Hald4 aut |
700 | 1 | a Woetmann, Anders4 aut |
700 | 1 | a Buus, Terkild Brink4 aut |
700 | 1 | a Odum, Niels4 aut |
710 | 2 | a Umeå universitetb Institutionen för molekylärbiologi (Medicinska fakulteten)4 org |
773 | 0 | t Oncoimmunologyd : Taylor & Francisg 8:11q 8:11x 2162-4011x 2162-402X |
856 | 4 | u https://doi.org/10.1080/2162402X.2019.1641387y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1341409/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161892 |
856 | 4 8 | u https://doi.org/10.1080/2162402X.2019.1641387 |
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