Sökning: onr:"swepub:oai:DiVA.org:umu-161986" > Lung Cancer Risk in...
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000 | 06786naa a2201237 4500 | |
001 | oai:DiVA.org:umu-161986 | |
003 | SwePub | |
008 | 190814s2019 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:aaa367fc-fa2c-487c-b5d1-d55a6d065ccd | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1619862 URI |
024 | 7 | a https://doi.org/10.1016/j.jtho.2019.04.0082 DOI |
024 | 7 | a https://lup.lub.lu.se/record/aaa367fc-fa2c-487c-b5d1-d55a6d065ccd2 URI |
040 | a (SwePub)umud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hung, Rayjean J.u Sinai Health System4 aut |
245 | 1 0 | a Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5(p)15.33 TERT-CLPTM1Ll Region |
264 | 1 | b ELSEVIER SCIENCE INC,c 2019 |
338 | a electronic2 rdacarrier | |
520 | a Introduction: Inherited susceptibility to lung cancer risk in never-smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study on the largest, to date, set of European-descent never-smokers with lung cancer. Methods: We conducted a two-phase (discovery and replication) genome-wide association study in never-smokers of European descent. We further augmented the sample by performing a meta-analysis with never-smokers from the recent OncoArray study, which resulted in a total of 3636 cases and 6295 controls. We also compare our findings with those in smokers with lung cancer. Results: We detected three genome-wide statistically significant single nucleotide polymorphisms rs31490 (odds ratio [OR]: 0.769, 95% confidence interval [CI]: 0.722-0.820; p value 5.31 x 10(-16)), rs380286 (OR: 0.770, 95% CI: 0.723-0.820; p value 4.32 x 10(-16)), and rs4975616 OR: 0.778, 95% CI: 0.730-0.829; p value 1.04 x 10(-14)). All three mapped to Chromosome 5 CLPTM1L-TERT region, previously shown to be associated with lung cancer risk in smokers and in never-smoker Asian women, and risk of other cancers including breast, ovarian, colorectal, and prostate. Conclusions: We found that genetic susceptibility to lung cancer in never-smokers is associated to genetic variants with pan-cancer risk effects. The comparison with smokers shows that top variants previously shown to be associated with lung cancer risk only confer risk in the presence of tobacco exposure, underscoring the importance of gene-environment interactions in the etiology of this disease. (C) 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Lung cancer | |
653 | a Never smokers | |
653 | a Genome-wide association study | |
653 | a Genetic susceptibility | |
653 | a Genetic susceptibility | |
653 | a Genome-wide association study | |
653 | a Lung cancer | |
653 | a Never smokers | |
700 | 1 | a Spitz, Margaret R.4 aut |
700 | 1 | a Houlston, Richard S.4 aut |
700 | 1 | a Schwartz, Ann G.4 aut |
700 | 1 | a Field, John K.4 aut |
700 | 1 | a Ying, Jun4 aut |
700 | 1 | a Li, Yafang4 aut |
700 | 1 | a Han, Younghun4 aut |
700 | 1 | a Ji, Xuemei4 aut |
700 | 1 | a Chen, Wei4 aut |
700 | 1 | a Wu, Xifeng4 aut |
700 | 1 | a Gorlov, Ivan P.4 aut |
700 | 1 | a Na, Jie4 aut |
700 | 1 | a de Andrade, Mariza4 aut |
700 | 1 | a Liu, Geoffrey4 aut |
700 | 1 | a Brhane, Yonathan4 aut |
700 | 1 | a Diao, Nancy4 aut |
700 | 1 | a Wenzlaff, Angela4 aut |
700 | 1 | a Davies, Michael P. A.4 aut |
700 | 1 | a Liloglou, Triantafillos4 aut |
700 | 1 | a Timofeeva, Maria4 aut |
700 | 1 | a Muley, Thomas4 aut |
700 | 1 | a Rennert, Hedy4 aut |
700 | 1 | a Saliba, Walid4 aut |
700 | 1 | a Ryan, Brid M.4 aut |
700 | 1 | a Bowman, Elise4 aut |
700 | 1 | a Barros-Dios, Juan-Miguel4 aut |
700 | 1 | a Perez-Rios, Monica4 aut |
700 | 1 | a Morgenstern, Hal4 aut |
700 | 1 | a Zienolddiny, Shanbeh4 aut |
700 | 1 | a Skaug, Vidar4 aut |
700 | 1 | a Ugolini, Donatella4 aut |
700 | 1 | a Bonassi, Stefano4 aut |
700 | 1 | a van der Heijden, Erik H. F. M.4 aut |
700 | 1 | a Tardon, Adonina4 aut |
700 | 1 | a Bojesen, Stig E.4 aut |
700 | 1 | a Landi, Maria Teresa4 aut |
700 | 1 | a Johansson, Mattias4 aut |
700 | 1 | a Bickeboeller, Heike4 aut |
700 | 1 | a Arnold, Susanne4 aut |
700 | 1 | a Le Marchand, Loic4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Andrew, Angeline4 aut |
700 | 1 | a Grankvist, Kjellu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002 |
700 | 1 | a Caporaso, Neil4 aut |
700 | 1 | a Teare, M. Dawn4 aut |
700 | 1 | a Schabath, Matthew B.4 aut |
700 | 1 | a Aldrich, Melinda C.4 aut |
700 | 1 | a Kiemeney, Lambertus A.4 aut |
700 | 1 | a Wichmann, H-Erich4 aut |
700 | 1 | a Lazarus, Philip4 aut |
700 | 1 | a Mayordomo, Jose4 aut |
700 | 1 | a Neri, Monica4 aut |
700 | 1 | a Haugen, Aage4 aut |
700 | 1 | a Zhang, Zuo-Feng4 aut |
700 | 1 | a Ruano-Ravina, Alberto4 aut |
700 | 1 | a Brenner, Hermann4 aut |
700 | 1 | a Harris, Curtis C.4 aut |
700 | 1 | a Orlow, Irene4 aut |
700 | 1 | a Rennert, Gadi4 aut |
700 | 1 | a Risch, Angela4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a Christiani, David C.4 aut |
700 | 1 | a Amos, Christopher I.4 aut |
700 | 1 | a Yang, Ping4 aut |
700 | 1 | a Gorlova, Olga Y.u Dartmouth College4 aut |
710 | 2 | a Sinai Health Systemb Kardiovaskulär forskning - hypertoni4 org |
710 | 2 | a et al. |
773 | 0 | t Journal of Thoracic Oncologyd : ELSEVIER SCIENCE INCg 14:8, s. 1360-1369q 14:8<1360-1369x 1556-0864x 1556-1380 |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1342593/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://www.jto.org/article/S1556086419302898/pdf |
856 | 4 | u http://dx.doi.org/10.1016/j.jtho.2019.04.008x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161986 |
856 | 4 8 | u https://doi.org/10.1016/j.jtho.2019.04.008 |
856 | 4 8 | u https://lup.lub.lu.se/record/aaa367fc-fa2c-487c-b5d1-d55a6d065ccd |
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