Sökning: onr:"swepub:oai:DiVA.org:umu-163067" >
Hypoxic ventilatory...
-
Christensson, E.Karolinska Institutet
(författare)
Hypoxic ventilatory response after rocuronium-induced partial neuromuscular blockade in men with obstructive sleep apnoea
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
-
2019-08-17
-
Blackwell Publishing,2020
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:umu-163067
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-163067URI
-
https://doi.org/10.1111/anae.14806DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:141608108URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Obstructive sleep apnoea and residual neuromuscular blockade are, independently, known to be risk factors for respiratory complications after major surgery. Residual effects of neuromuscular blocking agents are known to reduce the hypoxic ventilatory response in healthy volunteers. Patients with obstructive sleep apnoea have impaired control of breathing, but it is not known to what extent neuromuscular blocking agents interfere with the regulation of breathing in such patients. In a physiological study in 10 unsedated men with untreated obstructive sleep apnoea, we wished to examine if partial neuromuscular blockade had an effect on hypoxic ventilatory response (isocapnic hypoxia to oxygen saturation of 80%) and hypercapnic ventilatory response (normoxic inspired carbon dioxide 5%). The hypoxic ventilatory response was reduced by 32% (p = 0.016) during residual neuromuscular block (rocuronium to train-of-four ratio 0.7), but the hypercapnic ventilatory response was unaffected. We conclude that neuromuscular blockade specifically depresses peripheral chemosensitivity, and not respiratory muscle function since the hypercapnic ventilatory response was unaffected.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Ebberyd, A.Karolinska Institutet
(författare)
-
Hardemark Cedborg, A.
(författare)
-
Lodenius, A.Karolinska Institutet
(författare)
-
Osterlund Modalen, A.
(författare)
-
Franklin, Karl A.Umeå universitet,Kirurgi(Swepub:umu)kafr0021
(författare)
-
Eriksson, L. I.Karolinska Institutet
(författare)
-
Jonsson Fagerlund, M.Karolinska Institutet
(författare)
-
Karolinska InstitutetKirurgi
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Anaesthesia: Blackwell Publishing75:3, s. 338-3470003-24091365-2044
Internetlänk
Hitta via bibliotek
Till lärosätets databas