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Z-line alterations ...
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Wallner, Bengt,1962-Umeå universitet,Kirurgi,Umea Univ, Surg, Dept Surg & Perioperat Sci, Umea, Sweden
(författare)
Z-line alterations and gastroesophageal reflux : an endoscopic population-based prospective cohort study
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019-08-27
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TAYLOR & FRANCIS LTD,2019
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-164536
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-164536URI
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https://doi.org/10.1080/00365521.2019.1656775DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-175110URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-396106URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:141774718URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background and study aims: Barrett's esophagus is a premalignant condition in the distal esophagus associated with esophageal adenocarcinoma. Since gastroesophageal reflux is known to be of etiological importance in both Barrett's esophagus and esophageal adenocarcinoma, we aimed to study which endoscopic alterations at the Z-line can be attributed to a previous history of reflux symptoms. Patients and methods: From 1988, a population cohort in Sweden has been prospectively studied regarding gastrointestinal symptoms, using a validated questionnaire. In 2012, the population was invited to undergo a gastroscopy and participate in the present study. In order to determine which endoscopic alterations that can be attributed to a previous history of gastroesophageal reflux, three different endoscopic definitions of columnar-lined esophagus (CLE) were used: (1) ZAP I, An irregular Z-line with a suspicion of tongue-like protrusions; (2) ZAP II/III, Distinct, obvious tongues of metaplastic columnar epithelium; (3) CLE >= 1 cm, The Prague C/M-classification with a minimum length of 1 cm. Results: A total of 165 community subjects were included in the study. Of these, 40 had CLE >= 1 cm, 99 had ZAP I, and 26 had ZAP II/III. ZAP II/III was associated with an over threefold risk of previous GER symptoms (OR: 3.60, CI: 1.49-8.70). No association was found between gastroesophageal reflux and ZAP I (OR: 2.06, CI: 0.85-5.00), or CLE >= 1 cm (OR: 1.64, CI: 0.77-3.49). Conclusions: In a general community, the only endoscopic alteration to the Z-line definitely linked to longstanding GER symptoms was the presence of obvious tongues of metaplastic columnar epithelium (ZAP II/III).
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Björ, Ove,1967-Umeå universitet,Onkologi,Umea Univ, Oncol, Dept Radiat Sci, Umea, Sweden(Swepub:umu)ovbj0001
(författare)
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Andreasson, AnnaStockholms universitet,Stressforskningsinstitutet,Karolinska Institutet, Sweden,Karolinska Inst, Dept Med Solna, Stockholm, Sweden;Stockholm Univ, Stress Res Inst, Stockholm, Sweden(Swepub:su)anan6088
(författare)
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Vieth, MichaelKlinikum Bayreuth, Inst Pathol, Bayreuth, Germany
(författare)
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Schmidt, Peter T.Karolinska Institutet
(författare)
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Hellström, Per M.,1954-Uppsala universitet,Gastroenterologi/hepatologi(Swepub:uu)perhe742
(författare)
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Forsberg, AnnaKarolinska Inst, Dept Med Solna, Stockholm, Sweden
(författare)
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Talley, Nicholas J.Univ Newcastle, Fac Med, Newcastle, NSW, Australia
(författare)
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Agreus, LarsKarolinska Institutet
(författare)
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Umeå universitetKirurgi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Scandinavian Journal of Gastroenterology: TAYLOR & FRANCIS LTD54:9, s. 1065-10690036-55211502-7708
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Wallner, Bengt, ...
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Björ, Ove, 1967-
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Andreasson, Anna
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Vieth, Michael
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Schmidt, Peter T ...
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Hellström, Per M ...
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visa fler...
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Forsberg, Anna
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Talley, Nicholas ...
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Agreus, Lars
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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Scandinavian Jou ...
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Umeå universitet
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Stockholms universitet
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Karolinska Institutet