Sökning: onr:"swepub:oai:DiVA.org:umu-16482" >
Differential resist...
Differential resistance of melanoma cells to treatment with recombinant IFN-alpha2b and leukocyte IFN.
-
- Ruuth, Kristina (författare)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Lundgren
-
Berglund, Asa (författare)
-
Munoz, Varinia (författare)
-
visa fler...
-
- Lundgren, Erik (författare)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Lundgren
-
visa färre...
-
(creator_code:org_t)
- 2007
- 2007
- Engelska.
-
Ingår i: Anticancer Res. - 0250-7005. ; 27:4B, s. 2109-14
- Relaterad länk:
-
http://www.ncbi.nlm....
-
visa fler...
-
https://urn.kb.se/re...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: Interferon-alpha (IFN-alpha) subtypes bind to the same receptor and are expected to have the same biological functions. Whether or not leukocyte IFN, containing six major IFN-alpha proteins had the same anti-tumor effect as one subtype, recombinant IFN-alpha2b, was investigated. MATERIALS AND METHODS: Three melanoma lines were treated with both types of IFN, and the effect on proliferation and survival was estimated both after short-term and prolonged treatment. RESULTS: All the melanoma cell lines were sensitive to the antiproliferative effects of both IFN species during short-term treatment. However, upon prolonged culture, the frequency of resistant colony formation was significantly higher in cultures treated with IFN-alpha2b compared to those treated with leukocyte IFN. There was a qualitative difference between the resistant colonies selected by the two IFN species with respect to morphology, growth rate and sensitivity to apoptosis. CONCLUSION: The development of resistant clones occurred at a lower rate during long-term treatment with leukocyte IFN containing six major subtypes of IFN-alpha as compared to IFN-alpha2b.
Nyckelord
- Antineoplastic Agents/*pharmacology
- Cell Growth Processes/drug effects
- Drug Resistance; Neoplasm
- Humans
- Interferon Alfa-2b/*pharmacology
- Interferon-alpha/*pharmacology
- Melanoma/*drug therapy/pathology
- Tumor Cells; Cultured
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas