Sökning: onr:"swepub:oai:DiVA.org:umu-167062" >
Globus pallidal dee...
-
Cappon, Davide
(författare)
Globus pallidal deep brain stimulation for Tourette syndrome : Effects on cognitive function
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
-
Elsevier,2019
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:umu-167062
-
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-167062URI
-
https://doi.org/10.1016/j.parkreldis.2019.10.013DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Introduction: In a double-blind randomized crossover trial, we previously established that bilateral deep brain stimulation of the anteromedial globus pallidus internus (GPiam-DBS) is effective in significantly reducing tic severity in patients with refractory Tourette syndrome (TS). Here, we report the effects of bilateral GPiam-DBS on cognitive function in 11 of the 13 patients who had participated in our double-blind cross-over trial of GPi-DBS.Methods: Patients were assessed at baseline (4 weeks prior to surgery) and at the end of each of the three-month blinded periods, with stimulation either ON or OFF. The patients were evaluated on tests of memory (California Verbal Learning Test-II (CVLT-II); Corsi blocks; Short Recognition Memory for Faces), executive function (D-KEFS Stroop color-word interference, verbal fluency, Trail-making test, Hayling Sentence Completion test), and attention (Paced Auditory Serial Addition Test, Numbers and Letters Test).Results: GPiam-DBS did not produce any significant change in global cognition. Relative to pre-operative baseline assessment verbal episodic memory on the CVLT-II and set-shifting on the Trail-making Test were improved with DBS OFF. Performance on the cognitive tests were not different with DBS ON versus DBS OFF. GPiam-DBS did not alter aspects of cognition that are impaired in TS such as inhibition on the Stroop interference task or the Hayling Sentence Completion test.Conclusions: This study extends previous findings providing data showing that GPiam-DBS does not adversely affect cognitive domains such as memory, executive function, verbal fluency, attention, psychomotor speed, and information processing. These results indicate that GPiam-DBS does not produce any cognitive deficits in TS.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Beigi, Mazda
(författare)
-
Kefalopoulou, Zinovia
(författare)
-
Zrinzo, Ludvic
(författare)
-
Candelario, Joseph
(författare)
-
Milabo, Catherine
(författare)
-
Akram, Harith
(författare)
-
Dayal, Viswas
(författare)
-
Hyam, Jonathan
(författare)
-
Kass-Iliyya, Lewis
(författare)
-
Silverdale, Monty
(författare)
-
Evans, Julian
(författare)
-
Limousin, Patricia
(författare)
-
Hariz, MarwanUmeå universitet,Klinisk neurovetenskap,Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK(Swepub:umu)hama0032
(författare)
-
Joyce, Eileen
(författare)
-
Foltynie, Thomas
(författare)
-
Jahanshahi, Marjan
(författare)
-
Umeå universitetKlinisk neurovetenskap
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Parkinsonism & Related Disorders: Elsevier69, s. 14-181353-80201873-5126
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Cappon, Davide
-
Beigi, Mazda
-
Kefalopoulou, Zi ...
-
Zrinzo, Ludvic
-
Candelario, Jose ...
-
Milabo, Catherin ...
-
visa fler...
-
Akram, Harith
-
Dayal, Viswas
-
Hyam, Jonathan
-
Kass-Iliyya, Lew ...
-
Silverdale, Mont ...
-
Evans, Julian
-
Limousin, Patric ...
-
Hariz, Marwan
-
Joyce, Eileen
-
Foltynie, Thomas
-
Jahanshahi, Marj ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
- Artiklar i publikationen
-
Parkinsonism & R ...
- Av lärosätet
-
Umeå universitet