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Isoallopregnanolone...
Isoallopregnanolone; an antagonist to the anaesthetic effect of allopregnanolone in male rats
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- Bäckström, Torbjörn (författare)
- Umeå universitet,Obstetrik och gynekologi
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- Wahlström, Göran (författare)
- Umeå universitet,Obstetrik och gynekologi,Farmakologi
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- Wahlström, Kerstin (författare)
- Umeå universitet,Obstetrik och gynekologi,Farmakologi
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- Zhu, Di (författare)
- Umeå universitet,Obstetrik och gynekologi,Farmakologi
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- Wang, Ming-De (författare)
- Umeå universitet,Obstetrik och gynekologi,Farmakologi
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(creator_code:org_t)
- Amsterdam : North-Holland, 2005
- 2005
- Engelska.
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Ingår i: European Journal of Pharmacology. - Amsterdam : North-Holland. - 0014-2999 .- 1879-0712. ; 512:1, s. 15-21
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The interaction of isoallopregnanolone (3β-OH-5α-pregnan-20-one) on allopregnanolone (3α-OH-5α-pregnan-20-one) induced anaesthesia was studied in male rats using burst suppression of 1 s (“silent second”) with an electroencephalographic-threshold method. The i.v. administration of isoallopregnanolone was varied in relation to induction of “silent second”. Pre-treatment with isoallopregnanolone (12.5–50 mg/kg iv) 2 min prior to the threshold test gave an increase in the threshold dose of allopregnanolone(ANOVA df(3;36), F=13.61, P<0.001), which was dose dependent (r=0.73, b [slope]=0.08, df=38, P<0.001). After isoallopregnanolone pre-treatment, but not in the controls, anaesthesia time was positively related to the dose of allopregnanolone (r=0.52, b=1.72, df=28,P<0.01). Anaesthesia times were not influenced by a corresponding administration of isoallopregnanolone immediately after induction of “silent second”. When allopregnanolone and isoallopregnanolone were infused together at molar ratios of 1:1, 1:1.23, 1:1.43, a linear increase of the threshold doses of allopregnanolone was seen in relation to the dose of isoallopregnanolone (r=0.86, b=0.40, df=8,P<0.01). Thus isoallopregnanolone can antagonise the anaesthetic action of allopregnanolone.
Nyckelord
- Anesthetics/*antagonists & inhibitors/chemistry
- Animals
- Dose-Response Relationship; Drug
- Electroencephalography
- Male
- Pregnanolone/*antagonists & inhibitors/chemistry/*pharmacology
- Rats
- Rats; Sprague-Dawley
- Stereoisomerism
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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