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Increased Risk of C...
Increased Risk of Chronic Myeloid Leukemia Following Gastric Conditions Indicating Helicobacter pylori Infection : A Case-Control Study
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- Larfors, Gunnar (författare)
- Uppsala universitet,Hematologi
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- Richter, Johan (författare)
- Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden
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- Själander, Anders (författare)
- Umeå universitet,Avdelningen för medicin,Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden
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- Stenke, Leif (författare)
- Karolinska Institutet
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- Höglund, Martin (författare)
- Uppsala universitet,Hematologi
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(creator_code:org_t)
- Philadelphia : American Association of Cancer Research, 2020
- 2020
- Engelska.
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - Philadelphia : American Association of Cancer Research. - 1055-9965 .- 1538-7755. ; 29:1, s. 151-156
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
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- Background: On the basis of a previous report of increased chronic myeloid leukemia (CML) risk following peptic ulcer, we hypothesized that chronic Helicobacter pylori infection could serve as a risk factor for CML.Methods: In a population-based, retrospective case-control study, we used Swedish registry data on 980 patients with CML and 4,960 age- and sex-matched controls to investigate associations between markers of previous infection with Helicobacter pylori and CML incidence.Results: Previous diagnoses of dyspepsia, gastritis or peptic ulcers, as well as previous proton pump hibitor (PPI) medication, were all associated with a significantly increased risk of CML (RRs, 1.5-2.0; P = 0005-0.05). Meanwhile, neither inflammatory bowel disease nor intake of NSAIDs were associated with CML, indicating that it is not gastrointestinal ulcer or inflammation per se that influences risk.Conclusions: The consistent associations suggest a shared background between gastric conditions and CML, and strengthen the case that Helicobacter pylori could constitute this common risk factor.Impact: As the etiology of CML is practically unknown, and Helicobacter pylori could potentially be a therapeutic target, even this indirect evidence encourages further studies on the potential involvement of Helicobacter pylori in CML etiology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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