Sökning: onr:"swepub:oai:DiVA.org:umu-170433" > Recombination of B-...
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000 | 05179naa a2200421 4500 | |
001 | oai:DiVA.org:umu-170433 | |
003 | SwePub | |
008 | 200505s2020 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:uu-410069 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1704332 URI |
024 | 7 | a https://doi.org/10.1016/j.antiviral.2019.1046762 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4100692 URI |
040 | a (SwePub)umud (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Gaunt, Michael W.u London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England.4 aut |
245 | 1 0 | a Recombination of B- and T-cell epitope-rich loci from Aedes- and Culex-borne flaviviruses shapes Zika virus epidemiology |
264 | 1 | b Elsevier,c 2020 |
338 | a print2 rdacarrier | |
520 | a Sporadic human Zika virus (ZIKV) infections have been recorded in Africa and Asia since the 1950s. Major epidemics occurred only after ZIKV emerged in the Pacific islands and spread to the Americas. Specific biological determinants of the explosive epidemic nature of ZIKV have not been identified. Phylogenetic studies revealed incongruence in ZIKV placement in relation to Aedes-borne dengue viruses (DENV) and Cu/ex-borne flaviviruses. We hypothesized that this incongruence reflects interspecies recombination resulting in ZIKV evasion of cross-protective T-cell immunity. We investigated ZIKV phylogenetic incongruence in relation to: DENV T-cell epitope maps experimentally identified ex vivo, published B-cell epitope loci, and CD8(+) T-cell epitopes predicted in silico for mosquito-borne flaviviruses. Our findings demonstrate that the ZIKV proteome is a hybrid of Aedes-borne DENV proteins interspersed amongst Cu/ex-borne flavivirus proteins derived through independent interspecies recombination events. These analyses infer that DENV-associated proteins in the ZIKV hybrid proteome generated immunodominant human B-cell responses, whereas ZIKV recombinant derived Cu/ex-borne flavivirus-associated proteins generated immunodominant CD8(+) and/or CD4(+) T-cell responses. In silico CD8(+) T-cell epitope ZIKV cross-reactive prediction analyses verified this observation. We propose that by acquiring cytotoxic T-cell epitope-rich regions from Cu/ex-borne flaviviruses, ZIKV evaded DENV-generated T-cell immune cross-protection. Thus, Cu/ex-borne flaviviruses, including West Nile virus and Japanese encephalitis virus, might induce cross-protective T-cell responses against ZIKV. This would explain why explosive ZIKV epidemics occurred in DENV-endemic regions of Micronesia, Polynesia and the Americas where Cu/ex-borne flavivirus outbreaks are infrequent and why ZIKV did not cause major epidemics in Asia where Culex-borne flaviviruses are widespread. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
700 | 1 | a Gubler, Duane J.u Duke NUS Med Sch, Program Emerging Infect Dis, 8 Coll Rd, Singapore 169857, Singapore.4 aut |
700 | 1 | a Pettersson, John,d 1981-u Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Univ Sydney, Charles Perkins Ctr, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia.;Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia.4 aut0 (Swepub:uu)johpe964 |
700 | 1 | a Kuno, Gorou 1648 Collindale Dr, Ft Collins, CO 80525 USA.4 aut |
700 | 1 | a Wilder-Smith, Anneliesu Umeå universitet,Epidemiologi och global hälsa,London School of Hygiene and Tropical Medicine, Keppel Street, London, UK,London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England.;Umea Univ, Dept Publ Hlth & Clin Med, Epidemiol & Publ Hlth, Umea, Sweden.;Heidelberg Univ, Heidelberg Inst Global Hlth, Heidelberg, Germany.4 aut0 (Swepub:umu)anwi0099 |
700 | 1 | a de Lamballerie, Xavieru Aix Marseille Univ, UMR Unite Virus Emergents, IHU Mediterranee Infect 1207, INSERM,IRD 190, Marseille, France.4 aut |
700 | 1 | a Gould, Ernest A.u Aix Marseille Univ, UMR Unite Virus Emergents, IHU Mediterranee Infect 1207, INSERM,IRD 190, Marseille, France.4 aut |
700 | 1 | a Falconar, Andrew K.u Univ Norte, Dept Med, Barranquilla, Colombia.4 aut |
710 | 2 | a London Sch Hyg & Trop Med, Keppel St, London WC1E 7HT, England.b Duke NUS Med Sch, Program Emerging Infect Dis, 8 Coll Rd, Singapore 169857, Singapore.4 org |
773 | 0 | t Antiviral Researchd : Elsevierg 174q 174x 0166-3542x 1872-9096 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170433 |
856 | 4 8 | u https://doi.org/10.1016/j.antiviral.2019.104676 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-410069 |
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