Sökning: onr:"swepub:oai:DiVA.org:umu-170950" > Genetic interaction...
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000 | 08132naa a2201453 4500 | |
001 | oai:DiVA.org:umu-170950 | |
003 | SwePub | |
008 | 200519s2019 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:05595499-b514-4827-a203-33df74691d7c | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1709502 URI |
024 | 7 | a https://doi.org/10.18632/oncotarget.266782 DOI |
024 | 7 | a https://lup.lub.lu.se/record/05595499-b514-4827-a203-33df74691d7c2 URI |
040 | a (SwePub)umud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Li, Yafangu Baylor College of Medicine4 aut |
245 | 1 0 | a Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development |
264 | c 2019-03-05 | |
264 | 1 | b Impact Journals, LLC,c 2019 |
338 | a electronic2 rdacarrier | |
520 | a The development of cancer is driven by the accumulation of many oncogenesis-related genetic alterations and tumorigenesis is triggered by complex networks of involved genes rather than independent actions. To explore the epistasis existing among oncogenesis-related genes in lung cancer development, we conducted pairwise genetic interaction analyses among 35,031 SNPs from 2027 oncogenesis-related genes. The genotypes from three independent genome-wide association studies including a total of 24,037 lung cancer patients and 20,401 healthy controls with Caucasian ancestry were analyzed in the study. Using a two-stage study design including discovery and replication studies, and stringent Bonferroni correction for multiple statistical analysis, we identified significant genetic interactions between SNPs in RGL1:RAD51B (OR=0.44, p value=3.27x10-11 in overall lung cancer and OR=0.41, p value=9.71x10-11 in non-small cell lung cancer), SYNE1:RNF43 (OR=0.73, p value=1.01x10-12 in adenocarcinoma) and FHIT:TSPAN8 (OR=1.82, p value=7.62x10-11 in squamous cell carcinoma) in our analysis. None of these genes have been identified from previous main effect association studies in lung cancer. Further eQTL gene expression analysis in lung tissues provided information supporting the functional role of the identified epistasis in lung tumorigenesis. Gene set enrichment analysis revealed potential pathways and gene networks underlying molecular mechanisms in overall lung cancer as well as histology subtypes development. Our results provide evidence that genetic interactions between oncogenesis-related genes play an important role in lung tumorigenesis and epistasis analysis, combined with functional annotation, provides a valuable tool for uncovering functional novel susceptibility genes that contribute to lung cancer development by interacting with other modifier genes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a epistasis | |
653 | a functional annotation | |
653 | a lung cancer | |
653 | a oncogenesis | |
653 | a Epistasis | |
653 | a Functional annotation | |
653 | a Lung cancer | |
653 | a Oncogenesis | |
700 | 1 | a Xiao, Xiangjun4 aut |
700 | 1 | a Bossé, Yohan4 aut |
700 | 1 | a Gorlova, Olga4 aut |
700 | 1 | a Gorlov, Ivan4 aut |
700 | 1 | a Han, Younghun4 aut |
700 | 1 | a Byun, Jinyoung4 aut |
700 | 1 | a Leighl, Natasha4 aut |
700 | 1 | a Johansen, Jakob S.4 aut |
700 | 1 | a Barnett, Matt4 aut |
700 | 1 | a Chen, Chu4 aut |
700 | 1 | a Goodman, Gary4 aut |
700 | 1 | a Cox, Angela4 aut |
700 | 1 | a Taylor, Fiona4 aut |
700 | 1 | a Woll, Penella4 aut |
700 | 1 | a Wichmann, H. Erich4 aut |
700 | 1 | a Manz, Judith4 aut |
700 | 1 | a Muley, Thomas4 aut |
700 | 1 | a Risch, Angela4 aut |
700 | 1 | a Rosenberger, Albert4 aut |
700 | 1 | a Han, Jiali4 aut |
700 | 1 | a Siminovitch, Katherine4 aut |
700 | 1 | a Arnold, Susanne M.4 aut |
700 | 1 | a Haura, Eric B.4 aut |
700 | 1 | a Bolca, Ciprian4 aut |
700 | 1 | a Holcatova, Ivana4 aut |
700 | 1 | a Janout, Vladimir4 aut |
700 | 1 | a Kontic, Milica4 aut |
700 | 1 | a Lissowska, Jolanta4 aut |
700 | 1 | a Mukeria, Anush4 aut |
700 | 1 | a Ognjanovic, Simona4 aut |
700 | 1 | a Orlowski, Tadeusz M.4 aut |
700 | 1 | a Scelo, Ghislaine4 aut |
700 | 1 | a Swiatkowska, Beata4 aut |
700 | 1 | a Zaridze, David4 aut |
700 | 1 | a Bakke, Per4 aut |
700 | 1 | a Skaug, Vidar4 aut |
700 | 1 | a Zienolddiny, Shanbeh4 aut |
700 | 1 | a Duell, Eric J.4 aut |
700 | 1 | a Butler, Lesley M.4 aut |
700 | 1 | a Houlston, Richard4 aut |
700 | 1 | a Artigas, María Soler4 aut |
700 | 1 | a Grankvist, Kjellu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002 |
700 | 1 | a Johansson, Mikaelu Umeå universitet,Onkologi4 aut0 (Swepub:umu)mijo0025 |
700 | 1 | a Shepherd, Frances A.4 aut |
700 | 1 | a Marcus, Michael W.4 aut |
700 | 1 | a Brunnström, Hansu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups4 aut0 (Swepub:lu)med-hsb |
700 | 1 | a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)smi-jma |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Muller, David C.4 aut |
700 | 1 | a Overvad, Kim4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Liu, Geoffrey4 aut |
700 | 1 | a Bojesen, Stig E.4 aut |
700 | 1 | a Wu, Xifeng4 aut |
700 | 1 | a Le Marchand, Loic4 aut |
700 | 1 | a Albanes, Demetrios4 aut |
700 | 1 | a Bickeböller, Heike4 aut |
700 | 1 | a Aldrich, Melinda C.4 aut |
700 | 1 | a Bush, William S.4 aut |
700 | 1 | a Tardon, Adonina4 aut |
700 | 1 | a Rennert, Gad4 aut |
700 | 1 | a Teare, M. Dawn4 aut |
700 | 1 | a Field, John K.4 aut |
700 | 1 | a Kiemeney, Lambertus A.4 aut |
700 | 1 | a Lazarus, Philip4 aut |
700 | 1 | a Haugen, Aage4 aut |
700 | 1 | a Lam, Stephen4 aut |
700 | 1 | a Schabath, Matthew B.4 aut |
700 | 1 | a Andrew, Angeline S.4 aut |
700 | 1 | a Bertazzi, Pier Alberto4 aut |
700 | 1 | a Pesatori, Angela C.4 aut |
700 | 1 | a Christiani, David C.4 aut |
700 | 1 | a Caporaso, Neil4 aut |
700 | 1 | a Johansson, Mattias4 aut |
700 | 1 | a McKay, James D.4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a Hung, Rayjean J.4 aut |
700 | 1 | a Amos, Christopher I.u Dartmouth College4 aut |
710 | 2 | a Baylor College of Medicineb Klinisk kemi4 org |
710 | 2 | a et al. |
773 | 0 | t Oncotargetd : Impact Journals, LLCg 10:19, s. 1760-1774q 10:19<1760-1774x 1949-2553 |
856 | 4 | u https://doi.org/10.18632/oncotarget.26678y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1431069/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.oncotarget.com/article/26678/pdf/ |
856 | 4 | u http://dx.doi.org/10.18632/oncotarget.26678x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-170950 |
856 | 4 8 | u https://doi.org/10.18632/oncotarget.26678 |
856 | 4 8 | u https://lup.lub.lu.se/record/05595499-b514-4827-a203-33df74691d7c |
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