Sökning: onr:"swepub:oai:DiVA.org:umu-171442" >
Maternal Adipose Ti...
Maternal Adipose Tissue Expansion, A Missing Link in the Prediction of Birth Weight Centile
-
Jarvie, Eleanor M. (författare)
-
Stewart, Frances M. (författare)
-
Ramsay, Jane E. (författare)
-
visa fler...
-
Brown, E. Ann (författare)
-
Meyer, Barbara J. (författare)
-
- Olivecrona, Gunilla (författare)
- Umeå universitet,Fysiologisk kemi
-
Griffin, Bruce A. (författare)
-
Freeman, Dilys J. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2019-12-13
- 2020
- Engelska.
-
Ingår i: Journal of Clinical Endocrinology and Metabolism. - : Oxford University Press. - 0021-972X .- 1945-7197. ; 105:3, s. E814-E825
- Relaterad länk:
-
https://ro.uow.edu.a...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Context: Maternal body mass index (BMI) is associated with increased birth weight but does not explain all the variance in fetal adiposity.Objective: To assess the contribution of maternal body fat distribution to offspring birth weight and adiposity.Design: Longitudinal study throughout gestation and at delivery.Setting: Women recruited at 12 weeks of gestation and followed up at 26 and 36 weeks. Cord blood was collected at delivery.Patients: Pregnant women (n = 45) with BMI 18.0 to 46.3 kg/m(2) and healthy pregnancy outcome.Methods: Maternal first trimester abdominal subcutaneous and visceral adipose tissue thickness (SAT and VAT) was assessed by ultrasound.Main Outcome Measures: Maternal body fat distribution, maternal and cord plasma glucose and lipid concentrations, placental weight, birth weight, and fetal adiposity assessed by cord blood leptin.Results: VAT was the only anthropometric measure independently associated with birth weight centile (r(2) adjusted 15.8%, P=.002). BMI was associated with trimester 2 and trimesters 1 through 3 area under the curve (AUC) glucose and insulin resistance (Homeostatic Model Assessment). SAT alone predicted trimester 2 lipoprotein lipase (LPL) mass (a marker of adipocyte insulin sensitivity) (11.3%, P=.017). VAT was associated with fetal triglyceride (9.3%, P=.047). Placental weight was the only independent predictor of fetal adiposity (48%, P<.001). Maternal trimester 2 and AUC LPL were inversely associated with fetal adiposity (r = -0.69, P=.001 and r = -0.58, P=.006, respectively).Conclusions: Maternal VAT provides additional information to BMI for prediction of birth weight. VAT may be a marker of reduced SAT expansion and increased availability of maternal fatty acids for placental transport.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Pregnancy
- Adipose tissue
- Birth weight
- Insulin resistance
- Body fat distribution
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas