Sökning: onr:"swepub:oai:DiVA.org:umu-172560" > Temporal relations ...
Fältnamn | Indikatorer | Metadata |
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000 | 04318naa a2200673 4500 | |
001 | oai:DiVA.org:umu-172560 | |
003 | SwePub | |
008 | 200622s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1725602 URI |
024 | 7 | a https://doi.org/10.1093/europace/euz3122 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Camen, Stephan4 aut |
245 | 1 0 | a Temporal relations between atrial fibrillation and ischaemic stroke and their prognostic impact on mortality |
264 | c 2019-11-18 | |
264 | 1 | b Oxford University Press,c 2020 |
338 | a print2 rdacarrier | |
520 | a Aims Limited evidence is available on the temporal relationship between atrial fibrillation (AF) and ischaemic stroke and their impact on mortality in the community. We sought to understand the temporal relationship of AF and ischaemic stroke and to determine the sequence of disease onset in relation to mortality. Methods and results Across five prospective community cohorts of the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project we assessed baseline cardiovascular risk factors in 100 132 individuals, median age 46.1 (25th-75th percentile 35.8-57.5) years, 48.4% men. We followed them for incident ischaemic stroke and AF and determined the relation of subsequent disease diagnosis with overall mortality. Over a median follow-up of 16.1 years, N = 4555 individuals were diagnosed solely with AF, N = 2269 had an ischaemic stroke but no AF diagnosed, and N = 898 developed both, ischaemic stroke and AF. Temporal relationships showed a clustering of diagnosis of both diseases within the years around the diagnosis of the other disease. In multivariable-adjusted Cox regression analyses with time-dependent covariates subsequent diagnosis of AF after ischaemic stroke was associated with increased mortality [hazard ratio (HR) 4.05, 95% confidence interval (CI) 2.17-7.54; P < 0.001] which was also apparent when ischaemic stroke followed after the diagnosis of AF (HR 3.08, 95% CI 1.90-5.00; P < 0.001). Conclusion The temporal relations of ischaemic stroke and AF appear to be bidirectional. Ischaemic stroke may precede detection of AF by years. The subsequent diagnosis of both diseases significantly increases mortality risk. Future research needs to investigate the common underlying systemic disease processes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
653 | a Atrial fibrillation | |
653 | a Ischaemic stroke | |
653 | a Temporal relationship | |
653 | a Cohort study | |
700 | 1 | a Ojeda, Francisco M.4 aut |
700 | 1 | a Niiranen, Teemu4 aut |
700 | 1 | a Gianfagna, Francesco4 aut |
700 | 1 | a Vishram-Nielsen, Julie K.4 aut |
700 | 1 | a Costanzo, Simona4 aut |
700 | 1 | a Söderberg, Stefanu Umeå universitet,Kardiologi4 aut0 (Swepub:umu)stso0001 |
700 | 1 | a Vartiainen, Erkki4 aut |
700 | 1 | a Donati, Maria Benedetta4 aut |
700 | 1 | a Løchen, Maja-Lisa4 aut |
700 | 1 | a Pasterkamp, Gerard4 aut |
700 | 1 | a Magnussen, Christina4 aut |
700 | 1 | a Kee, Frank4 aut |
700 | 1 | a Jousilahti, Pekka4 aut |
700 | 1 | a Hughes, Maria4 aut |
700 | 1 | a Kontto, Jukka4 aut |
700 | 1 | a Mathiesen, Ellisiv B.4 aut |
700 | 1 | a Koenig, Wolfgang4 aut |
700 | 1 | a Palosaari, Tarja4 aut |
700 | 1 | a Blankenberg, Stefan4 aut |
700 | 1 | a de Gaetano, Giovanni4 aut |
700 | 1 | a Jorgensen, Torben4 aut |
700 | 1 | a Zeller, Tanja4 aut |
700 | 1 | a Kuulasmaa, Kari4 aut |
700 | 1 | a Linneberg, Allan4 aut |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Iacoviello, Licia4 aut |
700 | 1 | a Schnabel, Renate B.4 aut |
710 | 2 | a Umeå universitetb Kardiologi4 org |
773 | 0 | t Europaced : Oxford University Pressg 22:4, s. 522-529q 22:4<522-529x 1099-5129x 1532-2092 |
856 | 4 | u https://academic.oup.com/europace/article-pdf/22/4/522/32991362/euz312.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-172560 |
856 | 4 8 | u https://doi.org/10.1093/europace/euz312 |
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