Sökning: onr:"swepub:oai:DiVA.org:umu-173694" > Characterization of...
Fältnamn | Indikatorer | Metadata |
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000 | 04330naa a2200505 4500 | |
001 | oai:DiVA.org:umu-173694 | |
003 | SwePub | |
008 | 200723s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1736942 URI |
024 | 7 | a https://doi.org/10.3390/vaccines80303982 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Claesson, Rolfu Umeå universitet,Institutionen för odontologi,Aa-gruppen4 aut0 (Swepub:umu)rolf0001 |
245 | 1 0 | a Characterization of Aggregatibacter actinomycetemcomitans Serotype b Strains with Five Different, Including Two Novel, Leukotoxin Promoter Structures |
264 | c 2020-07-20 | |
264 | 1 | a Basel, Switzerland :b MDPI,c 2020 |
338 | a electronic2 rdacarrier | |
520 | a The JP2 genotype of A. actinomycetemcomitans, serotype b has attracted much interest during the past three decades due to its close association with periodontitis in young individuals and the enhanced expression of a leukotoxin (LtxA). A typical feature of this genotype is a 530-base pair (bp) deletion in the ltxCABD promoter region controlling leukotoxin expression. In the present work, we have characterized serotype b strains with four additional promoter types. Two novel types have been recognized, that is, one with a 230-bp deletion and one with a 172-bp duplication. Moreover, a strain with a 640-bp deletion and three strains with a full-length promoter, including the type strain Y4, were included in the present study. The seven strains were characterized by multi locus sequence typing (MLST) and arbitrarily primed polymerase chain reaction (PCR) and assessed for LtxA production. MLST showed that the strains with the non-JP2-like deletions represented distinct monophyletic groups, whereas the JP2 strain, HK1651, represented a separate branch. LtxA production was high in all three strains with a promoter deletion, whereas the other four strains showed significantly lower levels. It can be concluded that the genetic characterization and determination of LtxA production of A. actinomycetemcomitans isolates from individuals with periodontitis can contribute to the identification of novel virulent genotypes of this bacterium. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologi0 (SwePub)3042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnology0 (SwePub)3042 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinsk bioteknologix Medicinsk bioteknologi0 (SwePub)304012 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Medical Biotechnologyx Medical Biotechnology0 (SwePub)304012 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
653 | a Aggregatibacter actinomycetemcomitans | |
653 | a leukotoxicity | |
653 | a leukotoxin promoter types | |
653 | a genotyping | |
653 | a mikrobiologi | |
653 | a Microbiology | |
700 | 1 | a Chiang, Huei-Minu Umeå universitet,Institutionen för odontologi,Aa-gruppen4 aut0 (Swepub:umu)huch0003 |
700 | 1 | a Lindholm, Marku Umeå universitet,Institutionen för odontologi,Aa-gruppen4 aut0 (Swepub:umu)maan0243 |
700 | 1 | a Höglund-Åberg, Carolau Umeå universitet,Institutionen för odontologi,Aa-gruppen4 aut0 (Swepub:umu)caha0028 |
700 | 1 | a Haubek, Dorteu Aarhus University, Denmark4 aut |
700 | 1 | a Johansson, Anders,d 1955-u Umeå universitet,Institutionen för odontologi,Aa-gruppen4 aut0 (Swepub:umu)anjo0002 |
700 | 1 | a Oscarsson, Janu Umeå universitet,Institutionen för odontologi,Aa-gruppen4 aut0 (Swepub:umu)jaos0004 |
710 | 2 | a Umeå universitetb Institutionen för odontologi4 org |
773 | 0 | t Vaccinesd Basel, Switzerland : MDPIg 8:3q 8:3x 2076-393X |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1455384/FULLTEXT01.pdfx primaryx Raw objecty fulltext:postprint |
856 | 4 | u https://www.mdpi.com/2076-393X/8/3/398/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-173694 |
856 | 4 8 | u https://doi.org/10.3390/vaccines8030398 |
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