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Validation of a UPD...
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Ramsay, Neil
(författare)
Validation of a UPDRS-/MDS-UPDRS-based definition of functional dependency for Parkinson's disease
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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Elsevier,2020
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-176625
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-176625URI
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https://doi.org/10.1016/j.parkreldis.2020.05.034DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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INTRODUCTION: Functional dependency in basic activities of daily living (ADLs) is a key outcome in Parkinson's disease (PD). We aimed to define dependency in PD, using the original and MDS versions of the Unified Parkinson's Disease Rating Scale (UPDRS).METHODS: We developed two algorithms to define dependency from items of UPDRS Part 2 and MDS-UPDRS Part 2 relating to basic ADLs (feeding, dressing, hygiene and walking, and getting out of a chair). We validated both algorithms using data from 1110 patients from six community-based PD incidence cohorts, testing concurrent validity, convergent validity, and predictive validity.RESULTS: Our optimal algorithm showed high specificity and moderate to high sensitivity versus Schwab & England <80% (specificity 95% [95% confidence interval (CI) 93-97] and sensitivity 65% [95% CI 55-73] at baseline; 88% [95% CI 85-91] and 85% [95% CI 79-97] respectively at five-years follow-up). Convergent validity was demonstrated by strong associations between dependency defined by the algorithm and cognition (MMSE), quality of life (PDQ39), and impairment (UPDRS part 3) (all p < 0.001). Algorithm-defined dependency status also predicted mortality: HR for mortality in those dependent vs independent at baseline was 1.6 (95%CI 1.2-2.1) and in those dependent vs independent at five-years' follow-up was 2.2 (1.6-3.0).DISCUSSION: We have demonstrated the concurrent validity, convergent validity, and predictive validity of a UPDRS-/MDS-UPDRS-based algorithm to define functional dependency in PD. This can be used for studying dependency in any study where UPDRS or MDS-UPDRS part 2 data have been collected.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Macleod, Angus D.
(författare)
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Alves, Guido
(författare)
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Camacho, Marta
(författare)
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Forsgren, LarsUmeå universitet,Neurovetenskaper(Swepub:umu)lafo0001
(författare)
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Lawson, Rachael A.
(författare)
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Maple-Grødem, Jodi
(författare)
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Tysnes, Ole-Bjørn
(författare)
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Williams-Gray, Caroline H.
(författare)
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Yarnall, Alison J.
(författare)
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Counsell, Carl E.
(författare)
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Umeå universitetNeurovetenskaper
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Parkinsonism & Related Disorders: Elsevier76, s. 49-531353-80201873-5126
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Ramsay, Neil
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Macleod, Angus D ...
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Alves, Guido
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Camacho, Marta
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Forsgren, Lars
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Lawson, Rachael ...
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visa fler...
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Maple-Grødem, Jo ...
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Tysnes, Ole-Bjør ...
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Williams-Gray, C ...
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Yarnall, Alison ...
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Counsell, Carl E ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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Parkinsonism & R ...
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Umeå universitet