Sökning: onr:"swepub:oai:DiVA.org:umu-178121" > Discovery of rare v...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 17260naa a2203781 4500 | |
001 | oai:DiVA.org:umu-178121 | |
003 | SwePub | |
008 | 210105s2020 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:ab3cf679-db71-435f-9907-67f295345e04 | |
009 | oai:DiVA.org:uu-431051 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1781212 URI |
024 | 7 | a https://doi.org/10.1038/s41588-020-00713-x2 DOI |
024 | 7 | a https://lup.lub.lu.se/record/ab3cf679-db71-435f-9907-67f295345e042 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4310512 URI |
040 | a (SwePub)umud (SwePub)lud (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Surendran, Praveenu University of Cambridge4 aut |
245 | 1 0 | a Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals |
264 | c 2020-11-23 | |
264 | 1 | b Nature Publishing Group,c 2020 |
338 | a print2 rdacarrier | |
500 | a Errata: Surendran, P., Feofanova, E.V., Lahrouchi, N. et al. Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nature Genetics 53, 762 (2021). https://doi.org/10.1038/s41588-021-00832-z | |
520 | a Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to similar to 1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (minor allele frequency <= 0.01) variant BP associations (P < 5 x 10(-8)), of which 32 were in new BP-associated loci and 55 were independent BP-associated single-nucleotide variants within known BP-associated regions. Average effects of rare variants (44% coding) were similar to 8 times larger than common variant effects and indicate potential candidate causal genes at new and known loci (for example, GATA5 and PLCB3). BP-associated variants (including rare and common) were enriched in regions of active chromatin in fetal tissues, potentially linking fetal development with BP regulation in later life. Multivariable Mendelian randomization suggested possible inverse effects of elevated systolic and diastolic BP on large artery stroke. Our study demonstrates the utility of rare-variant analyses for identifying candidate genes and the results highlight potential therapeutic targets. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Feofanova, Elena V.4 aut |
700 | 1 | a Lahrouchi, Najim4 aut |
700 | 1 | a Ntalla, Ioanna4 aut |
700 | 1 | a Karthikeyan, Savita4 aut |
700 | 1 | a Cook, James4 aut |
700 | 1 | a Chen, Lingyan4 aut |
700 | 1 | a Mifsud, Borbala4 aut |
700 | 1 | a Yao, Chen4 aut |
700 | 1 | a Tuomi, Tiinamaijau Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,University of Helsinki4 aut0 (Swepub:lu)ti8736tu |
700 | 1 | a Cartwright, James H.4 aut |
700 | 1 | a Hellwege, Jacklyn N.4 aut |
700 | 1 | a Giri, Ayush4 aut |
700 | 1 | a Tragante, Vinicius4 aut |
700 | 1 | a Thorleifsson, Gudmar4 aut |
700 | 1 | a Liu, Dajiang J.4 aut |
700 | 1 | a Prins, Bram P.4 aut |
700 | 1 | a Stewart, Isobel D.4 aut |
700 | 1 | a Cabrera, Claudia P.4 aut |
700 | 1 | a Eales, James M.4 aut |
700 | 1 | a Akbarov, Artur4 aut |
700 | 1 | a Auer, Paul L.4 aut |
700 | 1 | a Bielak, Lawrence F.4 aut |
700 | 1 | a Bis, Joshua C.4 aut |
700 | 1 | a Braithwaite, Vickie S.4 aut |
700 | 1 | a Brody, Jennifer A.4 aut |
700 | 1 | a Daw, E. Warwick4 aut |
700 | 1 | a Warren, Helen R.4 aut |
700 | 1 | a Drenos, Fotios4 aut |
700 | 1 | a Nielsen, Sune Fallgaard4 aut |
700 | 1 | a Faul, Jessica D.4 aut |
700 | 1 | a Fauman, Eric B.4 aut |
700 | 1 | a Fava, Cristianou Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-cfa |
700 | 1 | a Ferreira, Teresa4 aut |
700 | 1 | a Foley, Christopher N.4 aut |
700 | 1 | a Franceschini, Nora4 aut |
700 | 1 | a Gao, He4 aut |
700 | 1 | a Giannakopoulou, Olga4 aut |
700 | 1 | a Giulianini, Franco4 aut |
700 | 1 | a Gudbjartsson, Daniel F.4 aut |
700 | 1 | a Guo, Xiuqing4 aut |
700 | 1 | a Harris, Sarah E.4 aut |
700 | 1 | a Havulinna, Aki S.4 aut |
700 | 1 | a Helgadottir, Anna4 aut |
700 | 1 | a Huffman, Jennifer E.4 aut |
700 | 1 | a Hwang, Shih-Jen4 aut |
700 | 1 | a Kanoni, Stavroula4 aut |
700 | 1 | a Kontto, Jukka4 aut |
700 | 1 | a Larson, Martin G.4 aut |
700 | 1 | a Li-Gao, Ruifang4 aut |
700 | 1 | a Lindstrom, Jaana4 aut |
700 | 1 | a Lotta, Luca A.4 aut |
700 | 1 | a Lu, Yingchang4 aut |
700 | 1 | a Luan, Jian'an4 aut |
700 | 1 | a Mahajan, Anubha4 aut |
700 | 1 | a Malerba, Giovanni4 aut |
700 | 1 | a Masca, Nicholas G. D.4 aut |
700 | 1 | a Mei, Hao4 aut |
700 | 1 | a Menni, Cristina4 aut |
700 | 1 | a Mook-Kanamori, Dennis O.4 aut |
700 | 1 | a Mosen-Ansorena, David4 aut |
700 | 1 | a Muller-Nurasyid, Martina4 aut |
700 | 1 | a Pare, Guillaume4 aut |
700 | 1 | a Paul, Dirk S.4 aut |
700 | 1 | a Perola, Markus4 aut |
700 | 1 | a Poveda, Alaitzu Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-azp |
700 | 1 | a Rauramaa, Rainer4 aut |
700 | 1 | a Richard, Melissa4 aut |
700 | 1 | a Richardson, Tom G.4 aut |
700 | 1 | a Sepulveda, Nuno4 aut |
700 | 1 | a Sim, Xueling4 aut |
700 | 1 | a Smith, Albert, V4 aut |
700 | 1 | a Smith, Jennifer A.4 aut |
700 | 1 | a Staley, James R.4 aut |
700 | 1 | a Stanakova, Alena4 aut |
700 | 1 | a Sulem, Patrick4 aut |
700 | 1 | a Theriault, Sebastien4 aut |
700 | 1 | a Thorsteinsdottir, Unnur4 aut |
700 | 1 | a Trompet, Stella4 aut |
700 | 1 | a V. Varga, Tiboru Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-tv_ |
700 | 1 | a Edwards, Digna R. Velez4 aut |
700 | 1 | a Veronesi, Giovanni4 aut |
700 | 1 | a Weiss, Stefan4 aut |
700 | 1 | a Willems, Sara M.4 aut |
700 | 1 | a Yao, Jie4 aut |
700 | 1 | a Young, Robin4 aut |
700 | 1 | a Yu, Bing4 aut |
700 | 1 | a Zhang, Weihua4 aut |
700 | 1 | a Zhao, Jing-Hua4 aut |
700 | 1 | a Zhao, Wei4 aut |
700 | 1 | a Evangelou, Evangelos4 aut |
700 | 1 | a Aeschbacher, Stefanie4 aut |
700 | 1 | a Asllanaj, Eralda4 aut |
700 | 1 | a Blankenberg, Stefan4 aut |
700 | 1 | a Bonnycastle, Lori L.4 aut |
700 | 1 | a Bork-Jensen, Jette4 aut |
700 | 1 | a Brandslund, Ivan4 aut |
700 | 1 | a Braund, Peter S.4 aut |
700 | 1 | a Burgess, Stephen4 aut |
700 | 1 | a Cho, Kelly4 aut |
700 | 1 | a Christensen, Cramer4 aut |
700 | 1 | a Connell, John4 aut |
700 | 1 | a de Mutsert, Renee4 aut |
700 | 1 | a Dominiczak, Anna F.4 aut |
700 | 1 | a Dorr, Marcus4 aut |
700 | 1 | a Eiriksdottir, Gudny4 aut |
700 | 1 | a Farmaki, Aliki-Eleni4 aut |
700 | 1 | a Gaziano, J. Michael4 aut |
700 | 1 | a Grarup, Niels4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Helsinki4 aut0 (Swepub:lu)endo-lgr |
700 | 1 | a Hallmans, Göran,d 1947-u Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001 |
700 | 1 | a Hansen, Torben4 aut |
700 | 1 | a Have, Christian T.4 aut |
700 | 1 | a Heiss, Gerardo4 aut |
700 | 1 | a Jorgensen, Marit E.4 aut |
700 | 1 | a Jousilahti, Pekka4 aut |
700 | 1 | a Kajantie, Eero4 aut |
700 | 1 | a Kamat, Mihir4 aut |
700 | 1 | a Karajamaki, AnneMari4 aut |
700 | 1 | a Karpe, Fredrik4 aut |
700 | 1 | a Koistinen, Heikki A.4 aut |
700 | 1 | a Kovesdy, Csaba P.4 aut |
700 | 1 | a Kuulasmaa, Kari4 aut |
700 | 1 | a Laatikainen, Tiina4 aut |
700 | 1 | a Lannfelt, Lars4 aut |
700 | 1 | a Lee, I-Te4 aut |
700 | 1 | a Lee, Wen-Jane4 aut |
700 | 1 | a Linneberg, Allan4 aut |
700 | 1 | a Martin, Lisa W.4 aut |
700 | 1 | a Moitry, Marieu University of Cambridge,Novo Nordisk Research Centre Oxford4 aut |
700 | 1 | a Nadkarni, Girish4 aut |
700 | 1 | a Neville, Matt J.4 aut |
700 | 1 | a Palmer, Colin N. A.4 aut |
700 | 1 | a Papanicolaou, George J.4 aut |
700 | 1 | a Pedersen, Oluf4 aut |
700 | 1 | a Peters, James4 aut |
700 | 1 | a Poulter, Neil4 aut |
700 | 1 | a Rasheed, Asif4 aut |
700 | 1 | a Rasmussen, Katrine L.4 aut |
700 | 1 | a Rayner, N. William4 aut |
700 | 1 | a Magi, Reedik4 aut |
700 | 1 | a Renström, Fridau Lund University,Lunds universitet,Umeå universitet,Näringsforskning,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Sweden,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-frm |
700 | 1 | a Rettig, Rainer4 aut |
700 | 1 | a Rossouw, Jacques4 aut |
700 | 1 | a Schreiner, Pamela J.4 aut |
700 | 1 | a Sever, Peter S.4 aut |
700 | 1 | a Sigurdsson, Emil L.4 aut |
700 | 1 | a Skaaby, Tea4 aut |
700 | 1 | a Sun, Yan, V4 aut |
700 | 1 | a Sundström, Johan,c Professor,d 1971-u Uppsala universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:uu)johasund |
700 | 1 | a Thorgeirsson, Gudmundur4 aut |
700 | 1 | a Esko, Tonu4 aut |
700 | 1 | a Trabetti, Elisabetta4 aut |
700 | 1 | a Tsao, Philip S.4 aut |
700 | 1 | a Tuomi, Tiinamaija4 aut |
700 | 1 | a Turner, Stephen T.4 aut |
700 | 1 | a Tzoulaki, Ioanna4 aut |
700 | 1 | a Vaartjes, Ilonca4 aut |
700 | 1 | a Vergnaud, Anne-Claire4 aut |
700 | 1 | a Willer, Cristen J.4 aut |
700 | 1 | a Wilson, Peter W. F.4 aut |
700 | 1 | a Witte, Daniel R.4 aut |
700 | 1 | a Yonova-Doing, Ekaterina4 aut |
700 | 1 | a Zhang, He4 aut |
700 | 1 | a Aliya, Naheed4 aut |
700 | 1 | a Almgren, Peteru Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Kardiovaskulär forskning - hypertoni,Diabetes - Cardiovascular Disease,Lund University Research Groups,Cardiovascular Research - Hypertension4 aut0 (Swepub:lu)endo-pal |
700 | 1 | a Amouyel, Philippe4 aut |
700 | 1 | a Asselbergs, Folkert W.4 aut |
700 | 1 | a Barnes, Michael R.4 aut |
700 | 1 | a Blakemore, Alexandra, I4 aut |
700 | 1 | a Boehnke, Michael4 aut |
700 | 1 | a Bots, Michiel L.4 aut |
700 | 1 | a Bottinger, Erwin P.4 aut |
700 | 1 | a Buring, Julie E.4 aut |
700 | 1 | a Chambers, John C.4 aut |
700 | 1 | a Chen, Yii-Der Ida4 aut |
700 | 1 | a Chowdhury, Rajiv4 aut |
700 | 1 | a Conen, David4 aut |
700 | 1 | a Correa, Adolfo4 aut |
700 | 1 | a Smith, George Davey4 aut |
700 | 1 | a de Boer, Rudolf A.4 aut |
700 | 1 | a Deary, Ian J.4 aut |
700 | 1 | a Dedoussis, George4 aut |
700 | 1 | a Deloukas, Panos4 aut |
700 | 1 | a Di Angelantonio, Emanuele4 aut |
700 | 1 | a Elliott, Paul4 aut |
700 | 1 | a Felix, Stephan B.4 aut |
700 | 1 | a Ferrieres, Jean4 aut |
700 | 1 | a Ford, Ian4 aut |
700 | 1 | a Fornage, Myriam4 aut |
700 | 1 | a Franks, Paul W.u Umeå University,Lund University,Lunds universitet,Umeå universitet,Näringsforskning,Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Sweden; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA; Oxford Center for Diabetes, Endocrinology & Metabolism, Radcliff Department of Medicine, University of Oxford, Oxford,UK,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-plf |
700 | 1 | a Franks, Stephen4 aut |
700 | 1 | a Frossard, Philippe4 aut |
700 | 1 | a Gambaro, Giovanni4 aut |
700 | 1 | a Gaunt, Tom R.4 aut |
700 | 1 | a Groop, Leif4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Harris, Tamara B.4 aut |
700 | 1 | a Hayward, Caroline4 aut |
700 | 1 | a Hennig, Branwen J.4 aut |
700 | 1 | a Herzig, Karl-Heinz4 aut |
700 | 1 | a Ingelsson, Erik4 aut |
700 | 1 | a Tuomilehto, Jaakko4 aut |
700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
700 | 1 | a Jukema, J. Wouter4 aut |
700 | 1 | a Kardia, Sharon L. R.4 aut |
700 | 1 | a Kee, Frank4 aut |
700 | 1 | a Kooner, Jaspal S.4 aut |
700 | 1 | a Kooperberg, Charles4 aut |
700 | 1 | a Launer, Lenore J.4 aut |
700 | 1 | a Lind, Lars4 aut |
700 | 1 | a Loos, Ruth J. F.4 aut |
700 | 1 | a Majumder, Abdulla Al Shafi4 aut |
700 | 1 | a Laakso, Markku4 aut |
700 | 1 | a McCarthy, Mark, I4 aut |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Mohlke, Karen L.4 aut |
700 | 1 | a Murray, Alison D.4 aut |
700 | 1 | a Nordestgaard, Borge Gronne4 aut |
700 | 1 | a Orho-Melander, Marjuu Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups4 aut0 (Swepub:lu)endo-mor |
700 | 1 | a Packard, Chris J.4 aut |
700 | 1 | a Padmanabhan, Sandosh4 aut |
700 | 1 | a Palmas, Walter4 aut |
700 | 1 | a Polasek, Ozren4 aut |
700 | 1 | a Porteous, David J.4 aut |
700 | 1 | a Prentice, Andrew M.4 aut |
700 | 1 | a Province, Michael A.4 aut |
700 | 1 | a Relton, Caroline L.4 aut |
700 | 1 | a Rice, Kenneth4 aut |
700 | 1 | a Ridker, Paul M.4 aut |
700 | 1 | a Rolandsson, Olovu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)olro0005 |
700 | 1 | a Rosendaal, Frits R.4 aut |
700 | 1 | a Rotter, Jerome, I4 aut |
700 | 1 | a Rudan, Igor4 aut |
700 | 1 | a Salomaa, Veikko4 aut |
700 | 1 | a Samani, Nilesh J.4 aut |
700 | 1 | a Sattar, Naveed4 aut |
700 | 1 | a Sheu, Wayne H-H4 aut |
700 | 1 | a Smith, Blair H.4 aut |
700 | 1 | a Soranzo, Nicole4 aut |
700 | 1 | a Spector, Timothy D.4 aut |
700 | 1 | a Starr, John M.4 aut |
700 | 1 | a Sebert, Sylvain4 aut |
700 | 1 | a Taylor, Kent D.4 aut |
700 | 1 | a Lakka, Timo A.4 aut |
700 | 1 | a Timpson, Nicholas J.4 aut |
700 | 1 | a Tobin, Martin D.4 aut |
700 | 1 | a van der Harst, Pim4 aut |
700 | 1 | a van der Meer, Peter4 aut |
700 | 1 | a Ramachandran, Vasan S.4 aut |
700 | 1 | a Verweij, Niek4 aut |
700 | 1 | a Virtamo, Jarmo4 aut |
700 | 1 | a Volker, Uwe4 aut |
700 | 1 | a Weir, David R.4 aut |
700 | 1 | a Zeggini, Eleftheria4 aut |
700 | 1 | a Charchar, Fadi J.4 aut |
700 | 1 | a Wareham, Nicholas J.4 aut |
700 | 1 | a Langenberg, Claudia4 aut |
700 | 1 | a Tomaszewski, Maciej4 aut |
700 | 1 | a Butterworth, Adam S.4 aut |
700 | 1 | a Caulfield, Mark J.4 aut |
700 | 1 | a Danesh, John4 aut |
700 | 1 | a Edwards, Todd L.4 aut |
700 | 1 | a Holm, Hilma4 aut |
700 | 1 | a Hung, Adriana M.4 aut |
700 | 1 | a Lindgren, Cecilia M.4 aut |
700 | 1 | a Liu, Chunyu4 aut |
700 | 1 | a Manning, Alisa K.4 aut |
700 | 1 | a Morris, Andrew P.4 aut |
700 | 1 | a Morrison, Alanna C.4 aut |
700 | 1 | a O'Donnell, Christopher J.4 aut |
700 | 1 | a Psaty, Bruce M.4 aut |
700 | 1 | a Saleheen, Danish4 aut |
700 | 1 | a Stefansson, Kari4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Chasman, Daniel, I4 aut |
700 | 1 | a Levy, Daniel4 aut |
700 | 1 | a Newton-Cheh, Christopher4 aut |
700 | 1 | a Munroe, Patricia B.4 aut |
700 | 1 | a Howson, Joanna M. M.4 aut |
710 | 2 | a University of Cambridgeb Diabetiska komplikationer4 org |
710 | 2 | a et al. |
773 | 0 | t Nature Geneticsd : Nature Publishing Groupg 52:12, s. 1314-1332q 52:12<1314-1332x 1061-4036x 1546-1718 |
856 | 4 | u https://pure.rug.nl/ws/files/174218286/s41588_020_00713_x.pdf |
856 | 4 | u http://dx.doi.org/10.1038/s41588-020-00713-xy FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-178121 |
856 | 4 8 | u https://doi.org/10.1038/s41588-020-00713-x |
856 | 4 8 | u https://lup.lub.lu.se/record/ab3cf679-db71-435f-9907-67f295345e04 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431051 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy