Sökning: onr:"swepub:oai:DiVA.org:umu-179656" > A Transcriptome-Wid...
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000 | 06822naa a2201429 4500 | |
001 | oai:DiVA.org:umu-179656 | |
003 | SwePub | |
008 | 210205s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1796562 URI |
024 | 7 | a https://doi.org/10.1093/jnci/djz2462 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Zhong, Jun4 aut |
245 | 1 0 | a A Transcriptome-Wide Association Study Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer |
264 | c 2020-04-05 | |
264 | 1 | b Oxford University Press,c 2020 |
338 | a print2 rdacarrier | |
520 | a Background: Although 20 pancreatic cancer susceptibility loci have been identified through genome-wide association studies in individuals of European ancestry, much of its heritability remains unexplained and the genes responsible largely unknown. Methods: To discover novel pancreatic cancer risk loci and possible causal genes, we performed a pancreatic cancer transcriptome-wide association study in Europeans using three approaches: FUSION, MetaXcan, and Summary-MulTiXcan. We integrated genome-wide association studies summary statistics from 9040 pancreatic cancer cases and 12 496 controls, with gene expression prediction models built using transcriptome data from histologically normal pancreatic tissue samples (NCI Laboratory of Translational Genomics [n = 95] and Genotype-Tissue Expression v7 [n = 174] datasets) and data from 48 different tissues (Genotype-Tissue Expression v7, n = 74-421 samples). Results: We identified 25 genes whose genetically predicted expression was statistically significantly associated with pancreatic cancer risk (false discovery rate < .05), including 14 candidate genes at 11 novel loci (1p36.12: CELA3B; 9q31.1: SMC2, SMC2-AS1; 10q23.31: RP11-80H5.9; 12q13.13: SMUG1; 14q32.33: BTBD6; 15q23: HEXA; 15q26.1: RCCD1; 17q12: PNMT, CDK12, PGAP3; 17q22: SUPT4H1; 18q11.22: RP11-888D10.3; and 19p13.11: PGPEPI) and 11 at six known risk loci (5p15.33: TERT, CLPTMIL, ZDHHCIIB; 7p14.1: INHBA; 9q34.2: ABO; 13q12.2: PDX1; 13q22.1: KLF5; and 16q23.1: WDR59, CFDP1, BCAR1, TMEM170A). The association for 12 of these genes (CELA3B, SMC2, and PNMT at novel risk loci and TERT, CLPTMIL, INHBA, ABO, PDX1, KLF5, WDR59, CFDP1, and BCAR1 at known loci) remained statistically significant after Bonferroni correction. Conclusions: By integrating gene expression and genotype data, we identified novel pancreatic cancer risk loci and candidate functional genes that warrant further investigation. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Jermusyk, Ashley4 aut |
700 | 1 | a Wu, Lang4 aut |
700 | 1 | a Hoskins, Jason W.4 aut |
700 | 1 | a Collins, Irene4 aut |
700 | 1 | a Mocci, Evelina4 aut |
700 | 1 | a Zhang, Mingfeng4 aut |
700 | 1 | a Song, Lei4 aut |
700 | 1 | a Chung, Charles C.4 aut |
700 | 1 | a Zhang, Tongwu4 aut |
700 | 1 | a Xiao, Wenming4 aut |
700 | 1 | a Albanes, Demetrius4 aut |
700 | 1 | a Andreotti, Gabriella4 aut |
700 | 1 | a Arslan, Alan A.4 aut |
700 | 1 | a Babic, Ana4 aut |
700 | 1 | a Bamlet, William R.4 aut |
700 | 1 | a Beane-Freeman, Laura4 aut |
700 | 1 | a Berndt, Sonja4 aut |
700 | 1 | a Borgida, Ayelet4 aut |
700 | 1 | a Bracci, Paige M.4 aut |
700 | 1 | a Brais, Lauren4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a Bueno-de-Mesquita, Bas4 aut |
700 | 1 | a Buring, Julie4 aut |
700 | 1 | a Canzian, Federico4 aut |
700 | 1 | a Childs, Erica J.4 aut |
700 | 1 | a Cotterchio, Michelle4 aut |
700 | 1 | a Du, Mengmeng4 aut |
700 | 1 | a Duell, Eric J.4 aut |
700 | 1 | a Fuchs, Charles4 aut |
700 | 1 | a Gallinger, Steven4 aut |
700 | 1 | a Gaziano, J. Michael4 aut |
700 | 1 | a Giles, Graham G.4 aut |
700 | 1 | a Giovannucci, Edward4 aut |
700 | 1 | a Goggins, Michael4 aut |
700 | 1 | a Goodman, Gary E.4 aut |
700 | 1 | a Goodman, Phyllis J.4 aut |
700 | 1 | a Haiman, Christopher4 aut |
700 | 1 | a Hartge, Patricia4 aut |
700 | 1 | a Hasan, Manal4 aut |
700 | 1 | a Helzlsouer, Kathy J.4 aut |
700 | 1 | a Holly, Elizabeth A.4 aut |
700 | 1 | a Klein, Eric A.4 aut |
700 | 1 | a Kogevinas, Manolis4 aut |
700 | 1 | a Kurtz, Robert J.4 aut |
700 | 1 | a LeMarchand, Loic4 aut |
700 | 1 | a Malats, Nuria4 aut |
700 | 1 | a Mannisto, Satu4 aut |
700 | 1 | a Milne, Roger4 aut |
700 | 1 | a Neale, Rachel E.4 aut |
700 | 1 | a Ng, Kimmie4 aut |
700 | 1 | a Obazee, Ofure4 aut |
700 | 1 | a Oberg, Ann L.4 aut |
700 | 1 | a Orlow, Irene4 aut |
700 | 1 | a Patel, Alpa, V4 aut |
700 | 1 | a Peters, Ulrike4 aut |
700 | 1 | a Porta, Miquel4 aut |
700 | 1 | a Rothman, Nathaniel4 aut |
700 | 1 | a Scelo, Ghislaine4 aut |
700 | 1 | a Sesso, Howard D.4 aut |
700 | 1 | a Severi, Gianluca4 aut |
700 | 1 | a Sieri, Sabina4 aut |
700 | 1 | a Silverman, Debra4 aut |
700 | 1 | a Sund, Malinu Umeå universitet,Kirurgi4 aut0 (Swepub:umu)masu0021 |
700 | 1 | a Tjonneland, Anne4 aut |
700 | 1 | a Thornquist, Mark D.4 aut |
700 | 1 | a Tobias, Geoffrey S.4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Van den Eeden, Stephen K.4 aut |
700 | 1 | a Visvanathan, Kala4 aut |
700 | 1 | a Wactawski-Wende, Jean4 aut |
700 | 1 | a Wentzensen, Nicolas4 aut |
700 | 1 | a White, Emily4 aut |
700 | 1 | a Yu, Herbert4 aut |
700 | 1 | a Yuan, Chen4 aut |
700 | 1 | a Zeleniuch-Jacquotte, Anne4 aut |
700 | 1 | a Hoover, Robert4 aut |
700 | 1 | a Brown, Kevin4 aut |
700 | 1 | a Kooperberg, Charles4 aut |
700 | 1 | a Risch, Harvey A.4 aut |
700 | 1 | a Jacobs, Eric J.4 aut |
700 | 1 | a Li, Donghui4 aut |
700 | 1 | a Yu, Kai4 aut |
700 | 1 | a Shu, Xiao-Ou4 aut |
700 | 1 | a Chanock, Stephen J.4 aut |
700 | 1 | a Wolpin, Brian M.4 aut |
700 | 1 | a Stolzenberg-Solomon, Rachael Z.4 aut |
700 | 1 | a Chatterjee, Nilanjan4 aut |
700 | 1 | a Klein, Alison P.4 aut |
700 | 1 | a Smith, Jill P.4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Shi, Jianxin4 aut |
700 | 1 | a Petersen, Gloria M.4 aut |
700 | 1 | a Zheng, Wei4 aut |
700 | 1 | a Amundadottir, Laufey T.4 aut |
710 | 2 | a Umeå universitetb Kirurgi4 org |
773 | 0 | t Journal of the National Cancer Instituted : Oxford University Pressg 112:10q 112:10x 0027-8874x 1460-2105 |
856 | 4 | u https://academic.oup.com/jnci/article-pdf/112/10/1003/33879497/djz246.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-179656 |
856 | 4 8 | u https://doi.org/10.1093/jnci/djz246 |
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