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Genome-wide associa...
Genome-wide association meta-analysis identifies pleiotropic risk loci for aerodigestive squamous cell cancers
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- Lesseur, Corina (författare)
- Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, NY, New York, United States
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- Ferreiro-Iglesias, Aida (författare)
- Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- McKay, James D. (författare)
- Section of Genetics, Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, World Health Organization, Lyon, France
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visa fler...
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- Bossé, Yohan (författare)
- Department of Molecular Medicine, Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Quebec City, Canada
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- Johansson, Mattias (författare)
- Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Gaborieau, Valerie (författare)
- Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Landi, Maria Teresa (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Christiani, David C. (författare)
- Department of Environmental Health, Harvard TH Chan School of Public Health, Massachusetts General Hospital, MA, Boston, United States,University of Washington
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- Caporaso, Neil C. (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Bojesen, Stig E. (författare)
- Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen, Denmark
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- Amos, Christopher I. (författare)
- Department of Medicine, Baylor college of Medicine, TX, Houston, United States
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- Shete, Sanjay (författare)
- Department of Biostatistics, The University of Texas M.D. Anderson Cancer Center, TX, Houston, United States
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- Liu, Geoffrey (författare)
- Lunenfeld-Tanenbaum Research Institute of Sinai Health System, University of Toronto, Toronto, Canada
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- Rennert, Gadi (författare)
- Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel
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- Albanes, Demetrios (författare)
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States
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- Aldrich, Melinda C. (författare)
- Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, TN, Nashville, United States
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- Tardon, Adonina (författare)
- Faculty of Medicine, University of Oviedo, CIBERESP, Oviedo, Spain
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- Chen, Chu (författare)
- Department of Epidemiology, University of Washington School of Public Health and Community Medicine, WA, Seattle, United States
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- Triantafillos, Liloglou (författare)
- Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom,Liverpool Hope University
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- Field, John K. (författare)
- Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom,Liverpool Hope University
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- Teare, Marion Dawn (författare)
- School of Health and Related Research, University Of Sheffield, Sheffield, United Kingdom,Sheffield Hallam University
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- Kiemeney, Lambertus A. (författare)
- Radboud University Medical Center, Nijmegen, Netherlands
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- Diergaarde, Brenda (författare)
- Department of Human Genetics, University of Pittsburgh, PA, Pittsburgh, United States; Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States; UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States
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- Ferris, Robert L. (författare)
- UPMC Hillman Cancer Center, University of Pittsburgh, PA, Pittsburgh, United States
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- Zienolddiny, Shanbeh (författare)
- National Institute of Occupational Health, Oslo, Norway
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- Lam, Stephen (författare)
- British Columbia Cancer Agency, Vancouver, Canada
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- Olshan, Andrew F. (författare)
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States
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- Weissler, Mark C. (författare)
- Department of Otolaryngology/Head and Neck Surgery, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, Chapel Hill, United States
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- Lacko, Martin (författare)
- Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center, Maastricht, Netherlands
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- Risch, Angela (författare)
- University of Salzburg, Department of Biosciences and Cancer Cluster Salzburg, Salzburg, Austria; Division of Epigenomics, DKFZ – German Cancer Research Center, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany
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- Bickeböller, Heike (författare)
- Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany
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- Ness, Andy R. (författare)
- National Institute for Health Research (NIHR), Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom; Bristol Dental School, University of Bristol, Bristol, United Kingdom
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- Thomas, Steve (författare)
- Bristol Dental School, University of Bristol, Bristol, United Kingdom
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- Le Marchand, Loic (författare)
- Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii, HI, Honolulu, United States
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- Schabath, Matthew B. (författare)
- Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, FL, Tampa, United States
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- Wünsch-Filho, Victor (författare)
- Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil
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- Tajara, Eloiza H. (författare)
- Department of Molecular Biology, School of Medicine of São José do Rio Preto, São José do Rio Preto, Brazil
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- Andrew, Angeline S. (författare)
- Biomedical Data Science, Geisel School of Medicine at Dartmouth, Dartmouth College, NH, Hanover, United States
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- Clifford, Gary M. (författare)
- Infections Section, Infections and Cancer Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Lazarus, Philip (författare)
- Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, WA, Spokane, United States
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- Grankvist, Kjell (författare)
- Umeå University,Umeå universitet,Klinisk kemi
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- Johansson, Mikael (författare)
- Umeå University,Umeå universitet,Onkologi
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- Arnold, Susanne (författare)
- Markey Cancer Center, University of Kentucky, KY, Lexington, United States
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- Melander, Olle (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Brunnström, Hans (författare)
- Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Boccia, Stefania (författare)
- Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Roma, Italy; Department of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy,Catholic University of the Sacred Heart, Rome
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- Cadoni, Gabriella (författare)
- Dipartimento Patologia Testa Collo e Organi di Senso, Istituto di Clinica Otorinolaringoiatrica, Università Cattolica del Sacro Cuore, Roma, Italy; Dipartimento di Scienze dell’Invecchiamento, Neurologiche, Ortopediche e della Testa-Collo, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
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- Timens, Wim (författare)
- Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; GRIAC Research Institute, University of Groningen, Groningen, Netherlands
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- Obeidat, Ma'en (författare)
- Centre for Heart Lung Innovation, St Paul’s Hospital, The University of British Columbia, Vancouver, Canada
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- Xiao, Xiangjun (författare)
- Department of Medicine, Baylor college of Medicine, TX, Houston, United States
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- Houlston, Richard S. (författare)
- Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom
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- Hung, Rayjean J. (författare)
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada
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- Brennan, Paul (författare)
- Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization, Lyon, France
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(creator_code:org_t)
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et al
- 2021-03-05
- 2021
- Engelska.
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Ingår i: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 17:3
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual cancers have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. To identify novel and pleotropic SqCC risk variants, we performed a meta-analysis of GWAS data on lung SqCC (LuSqCC), oro/pharyngeal SqCC (OSqCC), laryngeal SqCC (LaSqCC) and esophageal SqCC (ESqCC) cancers, totaling 13,887 cases and 61,961 controls of European ancestry. We identified one novel genome-wide significant (Pmeta<5x10-8) aerodigestive SqCC susceptibility loci in the 2q33.1 region (rs56321285, TMEM273). Additionally, three previously unknown loci reached suggestive significance (Pmeta<5x10-7): 1q32.1 (rs12133735, near MDM4), 5q31.2 (rs13181561, TMEM173) and 19p13.11 (rs61494113, ABHD8). Multiple previously identified loci for aerodigestive SqCC also showed evidence of pleiotropy in at least another SqCC site, these include: 4q23 (ADH1B), 6p21.33 (STK19), 6p21.32 (HLA-DQB1), 9p21.33 (CDKN2B-AS1) and 13q13.1(BRCA2). Gene-based association and gene set enrichment identified a set of 48 SqCC-related genes to DNA damage and epigenetic regulation pathways. Our study highlights the importance of cross-cancer analyses to identify pleiotropic risk loci of histology-related cancers arising at distinct anatomical sites.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Lesseur, Corina
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Ferreiro-Iglesia ...
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McKay, James D.
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Bossé, Yohan
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Johansson, Matti ...
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Gaborieau, Valer ...
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Landi, Maria Ter ...
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Christiani, Davi ...
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Caporaso, Neil C ...
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Bojesen, Stig E.
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Amos, Christophe ...
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Shete, Sanjay
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Liu, Geoffrey
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Rennert, Gadi
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Albanes, Demetri ...
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Aldrich, Melinda ...
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Tardon, Adonina
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Chen, Chu
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Triantafillos, L ...
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Field, John K.
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Teare, Marion Da ...
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Kiemeney, Lamber ...
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Diergaarde, Bren ...
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Ferris, Robert L ...
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Zienolddiny, Sha ...
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Lam, Stephen
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Olshan, Andrew F ...
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Weissler, Mark C ...
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Lacko, Martin
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Risch, Angela
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Bickeböller, Hei ...
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Ness, Andy R.
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Thomas, Steve
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Le Marchand, Loi ...
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Schabath, Matthe ...
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Wünsch-Filho, Vi ...
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Tajara, Eloiza H ...
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Andrew, Angeline ...
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Clifford, Gary M ...
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Lazarus, Philip
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Grankvist, Kjell
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Johansson, Mikae ...
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Arnold, Susanne
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Melander, Olle
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Brunnström, Hans
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Boccia, Stefania
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Cadoni, Gabriell ...
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Timens, Wim
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Obeidat, Ma'en
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Xiao, Xiangjun
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Houlston, Richar ...
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Hung, Rayjean J.
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Brennan, Paul
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