Sökning: onr:"swepub:oai:DiVA.org:umu-182097" >
Synthesis and immun...
Synthesis and immunological evaluation of the unnatural β-linked mucin-1 Thomsen-Friedenreich conjugate
-
- Wu, Xuanjun (författare)
- National Glycoengineering Research Center, Shandong University, Shandong, Qingdao, China; Department of Chemistry, Michigan State University, MI, East Lansing, United States
-
- McFall-Boegeman, Hunter (författare)
- Department of Chemistry, Michigan State University, MI, East Lansing, United States; Institute for Quantitative Health Science and Engineering, Michigan State University, MI, East Lansing, United States
-
- Rashidijahanabad, Zahra (författare)
- Department of Chemistry, Michigan State University, MI, East Lansing, United States; Institute for Quantitative Health Science and Engineering, Michigan State University, MI, East Lansing, United States
-
visa fler...
-
- Liu, Kunli (författare)
- Department of Chemistry, Michigan State University, MI, East Lansing, United States; Institute for Quantitative Health Science and Engineering, Michigan State University, MI, East Lansing, United States
-
- Pett, Christian (författare)
- Umeå universitet,Kemiska institutionen,Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany
-
- Yu, Jin (författare)
- Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany
-
- Schorlemer, Manuel (författare)
- Umeå universitet,Kemiska institutionen,Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany
-
- Ramadan, Sherif (författare)
- Department of Chemistry, Michigan State University, MI, East Lansing, United States; Institute for Quantitative Health Science and Engineering, Michigan State University, MI, East Lansing, United States; Chemistry Department, Faculty of Science, Benha University, Qaliobiya, Benha, Egypt
-
- Behren, Sandra (författare)
- Umeå universitet,Kemiska institutionen
-
- Westerlind, Ulrika (författare)
- Umeå universitet,Kemiska institutionen,Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany
-
- Huang, Xuefei (författare)
- Department of Chemistry, Michigan State University, MI, East Lansing, United States; Institute for Quantitative Health Science and Engineering, Michigan State University, MI, East Lansing, United States; Department of Biomedical Engineering, Michigan State University, MI, East Lansing, United States
-
visa färre...
-
(creator_code:org_t)
- 2021
- 2021
- Engelska.
-
Ingår i: Organic and biomolecular chemistry. - : Royal Society of Chemistry. - 1477-0520 .- 1477-0539. ; 19:11, s. 2448-2455
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- MUC1 glycopeptides are attractive antigens for anti-cancer vaccine development. One potential drawback in using the native MUC1 glycopeptide for vaccine design is the instability of theO-glycosyl linkage between the glycan and the peptide backbone to glycosidase. To overcome this challenge, a MUC1 glycopeptide mimic has been synthesized with the galactose-galactosamine disaccharide linked with threonine (Thomsen-Friedenreich or Tf antigen) through an unnatural β-glycosyl bond. The resulting MUC1-β-Tf had a much-enhanced stability toward a glycosidase capable of cleaving the glycan from the corresponding MUC1 glycopeptide with the natural α-Tf linkage. The MUC1-β-Tf was subsequently conjugated with a powerful carrier bacteriophage Qβ. The conjugate induced high levels of IgG antibodies in clinically relevant human MUC1 transgenic mice, which cross-recognized not only the natural MUC1-α-Tf glycopeptide but also MUC1 expressing tumor cells, supporting the notion that a simple switch of the stereochemistry of the glycan/peptide linkage can be a strategy for anti-cancer vaccine epitope design for glycopeptides.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Wu, Xuanjun
-
McFall-Boegeman, ...
-
Rashidijahanabad ...
-
Liu, Kunli
-
Pett, Christian
-
Yu, Jin
-
visa fler...
-
Schorlemer, Manu ...
-
Ramadan, Sherif
-
Behren, Sandra
-
Westerlind, Ulri ...
-
Huang, Xuefei
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Medicinsk biotek ...
-
och Medicinsk biotek ...
- Artiklar i publikationen
-
Organic and biom ...
- Av lärosätet
-
Umeå universitet