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A comparison of com...
A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
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- Clasen, Joanna L. (författare)
- Imperial College London
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- Heath, Alicia K. (författare)
- International Agency for Research on Cancer, World Health Organization
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Van Puyvelde, Heleen (författare)
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- Huybrechts, Inge (författare)
- Imperial College London
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- Park, Jin Young (författare)
- University of Turin
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- Ferrari, Pietro (författare)
- University of Bergen
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- Johansson, Mattias (författare)
- International Agency for Research on Cancer, World Health Organization
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- Scelo, Ghislaine (författare)
- Aarhus University
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- Ulvik, Arve (författare)
- Danish Cancer Society
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- Midttun, Øivind (författare)
- German Cancer Research Centre
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- Ueland, Per Magne (författare)
- German Institute of Human Nutrition
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- Dahm, Christina C. (författare)
- University of Potsdam
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- Halkjær, Jytte (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO)
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- Olsen, Anja (författare)
- Istituto Nazionale dei Tumori
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- Johnson, Theron (författare)
- Azienda Ospedaliera Universitaria Federico II
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- Katzke, Verena (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Schulze, Matthias B. (författare)
- National Institute for Public Health and the Environment (RIVM)
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- Masala, Giovanna (författare)
- Catalan Institute of Oncology
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- Segrado, Francesco (författare)
- Bellvitge Biomedical Research Institute
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- de Magistris, Maria Santucci (författare)
- Andalusian School Of Public Health (EASP)
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- Sacerdote, Carlotta (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Ocké, Marga C. (författare)
- Murcia Regional Health Council
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- Luján-Barroso, Leila (författare)
- CIBER Epidemiology and Public Health (CIBERESP)
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- Ching-López, Ana (författare)
- Health Research Institute of Navarra (IDISNA)
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- Huerta, José María (författare)
- Health Research Institute of Navarra (IDISNA)
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- Ardanaz, Eva (författare)
- Health Research Institute of Navarra (IDISNA)
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Amiano, Pilar (författare)
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- Ericson, Ulrika (författare)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups,Skåne University Hospital
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- Manjer, Jonas (författare)
- Umeå University,Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Gylling, Björn, 1978- (författare)
- Umeå University,Umeå universitet,Patologi
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- Johansson, Ingegerd (författare)
- Umeå universitet,Institutionen för odontologi,University of Oxford
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- Schmidt, Julie (författare)
- Imperial College London
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- Weiderpass, Elisabete (författare)
- Imperial College London
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- Riboli, Elio (författare)
- Imperial College London
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- Cross, Amanda J. (författare)
- Imperial College London
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- Muller, David C. (författare)
- Imperial College London
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(creator_code:org_t)
- Oxford University Press, 2021
- 2021
- Engelska.
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Ingår i: American Journal of Clinical Nutrition. - : Oxford University Press. - 0002-9165 .- 1938-3207. ; 114:1, s. 338-347
- Relaterad länk:
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https://doi.org/10.1...
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https://academic.oup...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5'-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health.OBJECTIVES: We explored the sensitivity of 5 outcomes, namely PLP concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the 3´-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid ratio (PAr) to vitamin B6 intake as well as personal and lifestyle characteristics.MEDTHODS: Dietary intake and biomarker data were collected from participants from 3 nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC). Bayesian regression models assessed the associations of the 5 biomarker outcomes with vitamin B6 intake and personal and lifestyle covariates. Analogous models examined the relations of Hcy:Cys, Cysta:Cys, and HKr with PLP.RESULTS: In total, 4608 participants were included in the analyses. Vitamin B6 intake was most strongly associated with PLP, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95% credible interval (CrI): 1.50, 1.71]; Hcy:Cys 0.87 [95% CrI: 0.84, 0.90]; Cysta:Cys 0.89 [95% CrI: 0.84, 0.94]; HKr 0.88 [95% CrI: 0.85, 0.91]; PAr 1.00 [95% CrI: 0.95, 1.05]). PAr was most sensitive to age, and HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers.CONCLUSIONS: We found that 5 different markers, capturing different aspects of vitamin B6-related biological processes, varied in their associations with vitamin B6 intake and personal and lifestyle predictors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- PLP
- dietary biomarkers
- kynurenine pathway
- transsulfuration pathway
- vitamin B6
- dietary biomarkers
- kynurenine pathway
- PLP
- transsulfuration pathway
- vitamin B6
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Clasen, Joanna L ...
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Heath, Alicia K.
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Van Puyvelde, He ...
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Huybrechts, Inge
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Park, Jin Young
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Ferrari, Pietro
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visa fler...
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Johansson, Matti ...
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Scelo, Ghislaine
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Ulvik, Arve
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Midttun, Øivind
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Ueland, Per Magn ...
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Dahm, Christina ...
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Halkjær, Jytte
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Olsen, Anja
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Johnson, Theron
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Katzke, Verena
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Schulze, Matthia ...
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Masala, Giovanna
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Segrado, Frances ...
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de Magistris, Ma ...
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Sacerdote, Carlo ...
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Ocké, Marga C.
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Luján-Barroso, L ...
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Ching-López, Ana
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Huerta, José Mar ...
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Ardanaz, Eva
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Amiano, Pilar
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Ericson, Ulrika
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Manjer, Jonas
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Gylling, Björn, ...
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Johansson, Ingeg ...
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Schmidt, Julie
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Weiderpass, Elis ...
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Riboli, Elio
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Cross, Amanda J.
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Muller, David C.
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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American Journal ...
- Av lärosätet
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Umeå universitet
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Lunds universitet