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A comparison of com...
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Clasen, Joanna L.Imperial College London
(författare)
A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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Oxford University Press,2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-183235
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-183235URI
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https://doi.org/10.1093/ajcn/nqab045DOI
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https://lup.lub.lu.se/record/63867c3a-5a44-4477-ba27-c3bde7cd739eURI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND: Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5'-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health.OBJECTIVES: We explored the sensitivity of 5 outcomes, namely PLP concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the 3´-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid ratio (PAr) to vitamin B6 intake as well as personal and lifestyle characteristics.MEDTHODS: Dietary intake and biomarker data were collected from participants from 3 nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC). Bayesian regression models assessed the associations of the 5 biomarker outcomes with vitamin B6 intake and personal and lifestyle covariates. Analogous models examined the relations of Hcy:Cys, Cysta:Cys, and HKr with PLP.RESULTS: In total, 4608 participants were included in the analyses. Vitamin B6 intake was most strongly associated with PLP, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95% credible interval (CrI): 1.50, 1.71]; Hcy:Cys 0.87 [95% CrI: 0.84, 0.90]; Cysta:Cys 0.89 [95% CrI: 0.84, 0.94]; HKr 0.88 [95% CrI: 0.85, 0.91]; PAr 1.00 [95% CrI: 0.95, 1.05]). PAr was most sensitive to age, and HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers.CONCLUSIONS: We found that 5 different markers, capturing different aspects of vitamin B6-related biological processes, varied in their associations with vitamin B6 intake and personal and lifestyle predictors.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Heath, Alicia K.International Agency for Research on Cancer, World Health Organization
(författare)
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Van Puyvelde, Heleen
(författare)
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Huybrechts, IngeImperial College London
(författare)
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Park, Jin YoungUniversity of Turin
(författare)
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Ferrari, PietroUniversity of Bergen
(författare)
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Johansson, MattiasInternational Agency for Research on Cancer, World Health Organization
(författare)
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Scelo, GhislaineAarhus University
(författare)
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Ulvik, ArveDanish Cancer Society
(författare)
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Midttun, ØivindGerman Cancer Research Centre
(författare)
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Ueland, Per MagneGerman Institute of Human Nutrition
(författare)
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Dahm, Christina C.University of Potsdam
(författare)
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Halkjær, JytteInstitute for Cancer Research, Prevention and Clinical Network (ISPRO)
(författare)
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Olsen, AnjaIstituto Nazionale dei Tumori
(författare)
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Johnson, TheronAzienda Ospedaliera Universitaria Federico II
(författare)
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Katzke, VerenaCitta' della Salute e della Scienza Hospital-University of Turin
(författare)
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Schulze, Matthias B.National Institute for Public Health and the Environment (RIVM)
(författare)
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Masala, GiovannaCatalan Institute of Oncology
(författare)
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Segrado, FrancescoBellvitge Biomedical Research Institute
(författare)
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de Magistris, Maria SantucciAndalusian School Of Public Health (EASP)
(författare)
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Sacerdote, CarlottaCIBER Epidemiology and Public Health (CIBERESP)
(författare)
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Ocké, Marga C.Murcia Regional Health Council
(författare)
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Luján-Barroso, LeilaCIBER Epidemiology and Public Health (CIBERESP)
(författare)
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Ching-López, AnaHealth Research Institute of Navarra (IDISNA)
(författare)
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Huerta, José MaríaHealth Research Institute of Navarra (IDISNA)
(författare)
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Ardanaz, EvaHealth Research Institute of Navarra (IDISNA)
(författare)
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Amiano, Pilar
(författare)
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Ericson, UlrikaLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-upe
(författare)
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Manjer, JonasUmeå University,Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)smi-jma
(författare)
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Gylling, Björn,1978-Umeå University,Umeå universitet,Patologi(Swepub:umu)bjgy0001
(författare)
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Johansson, IngegerdUmeå universitet,Institutionen för odontologi,University of Oxford(Swepub:umu)injo0003
(författare)
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Schmidt, JulieImperial College London
(författare)
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Weiderpass, ElisabeteImperial College London
(författare)
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Riboli, ElioImperial College London
(författare)
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Cross, Amanda J.Imperial College London
(författare)
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Muller, David C.Imperial College London
(författare)
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Imperial College LondonInternational Agency for Research on Cancer, World Health Organization
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:American Journal of Clinical Nutrition: Oxford University Press114:1, s. 338-3470002-91651938-3207
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Clasen, Joanna L ...
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Heath, Alicia K.
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Van Puyvelde, He ...
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Huybrechts, Inge
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Park, Jin Young
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Ferrari, Pietro
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visa fler...
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Johansson, Matti ...
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Scelo, Ghislaine
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Ulvik, Arve
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Midttun, Øivind
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Ueland, Per Magn ...
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Dahm, Christina ...
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Halkjær, Jytte
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Olsen, Anja
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Johnson, Theron
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Katzke, Verena
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Schulze, Matthia ...
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Masala, Giovanna
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Segrado, Frances ...
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de Magistris, Ma ...
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Sacerdote, Carlo ...
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Ocké, Marga C.
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Luján-Barroso, L ...
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Ching-López, Ana
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Huerta, José Mar ...
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Ardanaz, Eva
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Amiano, Pilar
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Ericson, Ulrika
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Manjer, Jonas
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Gylling, Björn, ...
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Johansson, Ingeg ...
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Schmidt, Julie
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Weiderpass, Elis ...
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Riboli, Elio
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Cross, Amanda J.
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Muller, David C.
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