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Red blood cell fatt...
Red blood cell fatty acids and risk of colorectal cancer in the European Prospective investigation into cancer and nutrition (EPIC)
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- Linseisen, Jakob (författare)
- Department of Epidemiology, Ludwig-Maximilians-Universit€at Munchen, UNIKA-T, Augsburg, Germany; Clinical Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany; Department of Epidemiology, Ludwig-Maximilians-Universit€at Munchen, UNIKA-T Augsburg, Neus€asser Straße 47, Augsburg, Germany
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- Grundmann, Nina (författare)
- Department of Epidemiology, Ludwig-Maximilians-Universit€at Munchen, UNIKA-T, Augsburg, Germany; Clinical Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
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- Zoller, Dorothee (författare)
- Department of Epidemiology, Ludwig-Maximilians-Universit€at Munchen, UNIKA-T, Augsburg, Germany; German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
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- Kuhn, Tilman (författare)
- German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
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- Jansen, Eugene H.J.M. (författare)
- Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
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- Chajes, Veronique (författare)
- International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Fedirko, Veronika (författare)
- Department of Epidemiology, Rollins School of Public Health, Winship Cancer Institute, Emory University, GA, Atlanta, United States
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Dahm, Christina C. (författare)
- Department of Public Health, Aarhus University, Aarhus, Denmark
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- Overvad, Kim (författare)
- Department of Public Health, Aarhus University, Aarhus, Denmark; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
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- Tjønneland, Anne (författare)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark
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- Boutron-Ruault, Marie-Christine (författare)
- Centre de recherche en Epidemiologie et Sante des Populations (CESP), Institut National de la Sante et de la Recherche Medicale (Inserm) U1018, Faculte de Medecine, Universite Paris-Sud, Universite Paris-Saclay, Villejuif, France; Insti-tut de Cancerologie Gustave Roussy, Villejuif, France
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- Rothwell, Joseph A. (författare)
- Centre de recherche en Epidemiologie et Sante des Populations (CESP), Institut National de la Sante et de la Recherche Medicale (Inserm) U1018, Faculte de Medecine, Universite Paris-Sud, Universite Paris-Saclay, Villejuif, France; Insti-tut de Cancerologie Gustave Roussy, Villejuif, France
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- Severi, Gianluca (författare)
- Centre de recherche en Epidemiologie et Sante des Populations (CESP), Institut National de la Sante et de la Recherche Medicale (Inserm) U1018, Faculte de Medecine, Universite Paris-Sud, Universite Paris-Saclay, Villejuif, France; Insti-tut de Cancerologie Gustave Roussy, Villejuif, France; Department of Statistics, Computer Science and Applications (DISIA), University of Florence, Florence, Italy
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- Kaaks, Rudolf (författare)
- German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany
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- Schulze, Matthias B. (författare)
- German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
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- Aleksandrova, Krasimira (författare)
- German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
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- Sieri, Sabina (författare)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
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- Panico, Salvatore (författare)
- Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
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- Tumino, Rosario (författare)
- Cancer Registry and Histopathology Department, Provincial Health Authority, Ragusa, Italy
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- Masala, Giovanna (författare)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy
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- de Marco, Laura (författare)
- Cancer Epidemiology Unit, A.O.U. Citta della Salute e della Scienza Hospital and CPO Piemonte, Turin, Italy
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- Bueno-De-Mesquita, Bas (författare)
- Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands
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- Vermeulen, Roel (författare)
- Division of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands
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- Gram, Inger T. (författare)
- Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Arctic University of Norway, Tromsø, Norway
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- Skeie, Guri (författare)
- Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Arctic University of Norway, Tromsø, Norway
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- Chirlaque, María-Dolores (författare)
- Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Centro de Investigacion Biomedica en Red de Epidemiología y Salud Publica (CIBERESP), Madrid, Spain; Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain
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- Ardanaz, Eva (författare)
- Centro de Investigacion Biomedica en Red de Epidemiología y Salud Publica (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
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- Agudo, Antonio (författare)
- Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
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- Sánchez, Maria-Jose (författare)
- Centro de Investigacion Biomedica en Red de Epidemiología y Salud Publica (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Publica (EASP), Granada, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
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- Amiano, Pilar (författare)
- Centro de Investigacion Biomedica en Red de Epidemiología y Salud Publica (CIBERESP), Madrid, Spain; Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastian, Spain
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- Wennberg, Maria, 1974- (författare)
- Umeå universitet,Näringsforskning,Avdelningen för hållbar hälsa
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- Bodén, Stina (författare)
- Umeå universitet,Onkologi
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- Perez-Cornago, Aurora (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, Oxford, United Kingdom
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- Aglago, Elom K. (författare)
- International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Gunter, Marc J. (författare)
- International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Jenab, Mazda (författare)
- International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Heath, Alicia K. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Nieters, Alexandra (författare)
- Institute of Immunodeficiency, Medical Faculty, University Hospital Freiburg, Freiburg, Germany
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(creator_code:org_t)
- American Association for Cancer Research (AACR), 2021
- 2021
- Engelska.
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Ingår i: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research (AACR). - 1055-9965 .- 1538-7755. ; 30:5, s. 874-885
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer risk. However, data from large-scale epidemiologic studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce.Methods: We investigate the association between red blood cell (RBC) membrane FAs and risk of colorectal cancer in a case–control study nested within a large prospective cohort. After a median follow-up of 6.4 years, 1,069 incident colorectal cancer cases were identified and matched to 1,069 controls among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). The FA composition of RBC phospholipids (in mol%) was analyzed by gas chromatography, and their association with risk of colorectal cancer was estimated by multivariable adjusted conditional logistic regression models.Results: After correction for multiple testing, subjects with higher concentrations of RBC stearic acid were at higher risk for colorectal cancer (OR ¼ 1.23; 95% CI ¼ 1.07–1.42, per 1 mol%). Conversely, colorectal cancer incidence decreased with increasing proportions of RBC n-3 PUFA, particularly eicosapentaenoic acid (0.75; 0.62–0.92, per 1 mol%). The findings for the n-6 PUFA arachidonic acid were inconsistent.Conclusions: The positive association between prediagnostic RBC stearic acid and colorectal cancer reflects putative differences in FA intake and metabolism between cancer cases and matched controls, which deserve further investigation. The inverse relationship between EPA and colorectal cancer is in line with the repeatedly reported protective effect of fish consumption on colorectal cancer risk.Impact: These findings add to the evidence on colorectal cancer prevention.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Linseisen, Jakob
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Grundmann, Nina
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Zoller, Dorothee
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Kuhn, Tilman
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Jansen, Eugene H ...
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Chajes, Veroniqu ...
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visa fler...
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Fedirko, Veronik ...
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Weiderpass, Elis ...
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Dahm, Christina ...
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Overvad, Kim
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Tjønneland, Anne
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Boutron-Ruault, ...
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Rothwell, Joseph ...
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Severi, Gianluca
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Kaaks, Rudolf
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Schulze, Matthia ...
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Aleksandrova, Kr ...
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Sieri, Sabina
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Panico, Salvator ...
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Tumino, Rosario
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Masala, Giovanna
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de Marco, Laura
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Bueno-De-Mesquit ...
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Vermeulen, Roel
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Gram, Inger T.
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Skeie, Guri
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Chirlaque, María ...
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Ardanaz, Eva
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Agudo, Antonio
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Sánchez, Maria-J ...
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Amiano, Pilar
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Wennberg, Maria, ...
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Bodén, Stina
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Perez-Cornago, A ...
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Aglago, Elom K.
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Gunter, Marc J.
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Jenab, Mazda
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Heath, Alicia K.
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Nieters, Alexand ...
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MEDICIN OCH HÄLS ...
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Cancer Epidemiol ...
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