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Nicotinamide provid...
Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction
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- Tribble, James R. (författare)
- Karolinska Institutet
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- Otmani, Amin (författare)
- Karolinska Institutet
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- Sun, Shanshan (författare)
- School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
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- Ellis, Sevannah A. (författare)
- University of Melbourne, The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia
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- Cimaglia, Gloria (författare)
- Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden; School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK
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- Vohra, Rupali (författare)
- Department of Veterinary and Animal Sciences, Pathobiological Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Department of Drug Design and Pharmacology, Eye Translational Research Unit, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
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- Jöe, Melissa (författare)
- Karolinska Institutet
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- Lardner, Emma (författare)
- Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden
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- Venkataraman, Abinaya P. (författare)
- Karolinska Institutet
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- Domínguez-Vicent, Alberto (författare)
- Karolinska Institutet
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- Kokkali, Eirini (författare)
- School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom
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- Rho, Seungsoo (författare)
- School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK; Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea
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- Jóhannesson, Gauti, 1979- (författare)
- Umeå universitet,Oftalmiatrik,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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- Burgess, Robert W. (författare)
- Jackson Laboratory, ME, United States
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- Fuerst, Peter G. (författare)
- WWAMI Medical Education Program, University of Idaho, ID, Moscow, United States
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- Brautaset, Rune (författare)
- Karolinska Institutet
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- Kolko, Miriam (författare)
- Department of Drug Design and Pharmacology, Eye Translational Research Unit, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Department of Ophthalmology, Copenhagen University Hospital, Rigshospitalet-Glostrup, Glostrup, Denmark
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- Morgan, James E. (författare)
- School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK; Cardiff Eye Unit, University Hospital Wales, Cardiff, UK; School of Medicine, Cardiff University, Cardiff, UK
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- Crowston, Jonathan G. (författare)
- Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Australia; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore; Centre for Vision Research, Neuroscience and Behavioural Disorders, Duke-NUS, Singapore, Singapore
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- Votruba, Marcela (författare)
- School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK; Cardiff Eye Unit, University Hospital Wales, Cardiff, UK
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- Williams, Pete A. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier, 2021
- 2021
- Engelska.
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Ingår i: Redox Biology. - : Elsevier. - 2213-2317. ; 43
- Relaterad länk:
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https://umu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Nicotinamide adenine dinucleotide (NAD) is a REDOX cofactor and metabolite essential for neuronal survival. Glaucoma is a common neurodegenerative disease in which neuronal levels of NAD decline. We assess the effects of nicotinamide (a precursor to NAD) on retinal ganglion cells (the affected neuron in glaucoma) in normal physiological conditions and across a range of glaucoma relevant insults including mitochondrial stress and axon degenerative insults. We demonstrate retinal ganglion cell somal, axonal, and dendritic neuroprotection by nicotinamide in rodent models which represent isolated ocular hypertensive, axon degenerative, and mitochondrial degenerative insults. We performed metabolomics enriched for small molecular weight metabolites for the retina, optic nerve, and superior colliculus which demonstrates that ocular hypertension induces widespread metabolic disruption, including consistent changes to α-ketoglutaric acid, creatine/creatinine, homocysteine, and glycerophosphocholine. This metabolic disruption is prevented by nicotinamide. Nicotinamide provides further neuroprotective effects by increasing oxidative phosphorylation, buffering and preventing metabolic stress, and increasing mitochondrial size and motility whilst simultaneously dampening action potential firing frequency. These data support continued determination of the utility of long-term nicotinamide treatment as a neuroprotective therapy for human glaucoma.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Oftalmologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Ophthalmology (hsv//eng)
Nyckelord
- Glaucoma
- Metabolism
- Metabolomics
- Mitochondria
- Nicotinamide
- Retina
- Retinal ganglion cell
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Tribble, James R ...
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Otmani, Amin
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Sun, Shanshan
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Ellis, Sevannah ...
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Cimaglia, Gloria
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Vohra, Rupali
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visa fler...
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Jöe, Melissa
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Lardner, Emma
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Venkataraman, Ab ...
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Domínguez-Vicent ...
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Kokkali, Eirini
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Rho, Seungsoo
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Jóhannesson, Gau ...
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Burgess, Robert ...
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Fuerst, Peter G.
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Brautaset, Rune
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Kolko, Miriam
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Morgan, James E.
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Crowston, Jonath ...
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Votruba, Marcela
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Williams, Pete A ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Oftalmologi
- Artiklar i publikationen
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Redox Biology
- Av lärosätet
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Umeå universitet
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Karolinska Institutet