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  • Fedotkina, OlenaDepartment of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway (författare)

Perinatal famine is associated with excess risk of proliferative retinopathy in patients with type 2 diabetes

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2021-06-24
  • John Wiley & Sons,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-185545
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-185545URI
  • https://doi.org/10.1111/aos.14948DOI
  • https://lup.lub.lu.se/record/4d014f32-b639-4f4f-9eae-f704ca470332URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Purpose: Intrauterine undernutrition is associated with increased risk of type 2 diabetes. Children born premature or small for gestational age were reported to have abnormal retinal vascularization. However, whether intrauterine famine act as a trigger for diabetes complications, including retinopathy, is unknown. The aim of the current study was to evaluate long-term effects of perinatal famine on the risk of proliferative diabetic retinopathy (PDR).Methods: We studied the risk for PDR among type 2 diabetes patients exposed to perinatal famine in two independent cohorts: the Ukrainian National Diabetes Registry (UNDR) and the Hong Kong Diabetes Registry (HKDR). We analysed individuals born during the Great Famine (the Holodomor, 1932–1933) and the WWII (1941–1945) famine in 101 095 (3601 had PDR) UNDR participants. Among 3021 (251 had PDR) HKDR participants, we studied type 2 diabetes patients exposed to perinatal famine during the WWII Japanese invasion in 1942–1945.Results: During the Holodomor and WWII, perinatal famine was associated with a 1.76-fold (p = 0.019) and 3.02-fold (p = 0.001) increased risk of severe PDR in the UNDR. The risk for PDR was 1.66-fold elevated among individuals born in 1942 in the HKDR (p < 0.05). The associations between perinatal famine and PDR remained statistically significant after corrections for HbA1c in available 18 507 UNDR (padditive interaction < 0.001) and in 3021 HKDR type 2 diabetes patients (p < 0.05).Conclusion: In conclusion, type 2 diabetes patients, exposed to perinatal famine, have increased risk of PDR compared to those without perinatal famine exposure. Further studies are needed to understand the underlying mechanisms and to extend this finding to other diabetes complications.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Luk, AndreaHong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong (författare)
  • Jain, RuchiLund University,Lunds universitet,Öcellsfysiologi,Forskargrupper vid Lunds universitet,Islet cell physiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-ruj (författare)
  • Prasad, Rashmi BLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-rpa (författare)
  • Shungin, DmitryUmeå University,Umeå universitet,Institutionen för odontologi,Broad Institute of Harvard and MIT, MA, Cambridge, United States(Swepub:lu)med-dsn (författare)
  • Simó-Servat, OlgaVall d'Hebron Research Institute, Universitat Autònoma de Barcelona and CIBERDEM, Barcelona, Spain,Autonomous University of Barcelona (författare)
  • Özgümüs, TürkülerDepartment of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway (författare)
  • Cherviakova, LiubovChernihiv Regional Hospital, Chernihiv, Ukraine (författare)
  • Khalimon, NadiyaCity Hospital No 2, Chernihiv, Ukraine (författare)
  • Svietleisha, TetianaCity Hospital No 1, Chernihiv, Ukraine (författare)
  • Buldenko, TetianaDepartment of Health Care of Chernihiv Regional State Administration, Chernihiv, Ukraine (författare)
  • Kravchenko, VictorKomisarenko Institute of Endocrinology and Metabolism, Kyiv, Ukraine,V. P. Komisarenko Institute of Endocrinology and Metabolism of the Ukraine Academy of Medical Sciences (författare)
  • Hernández, CristinaVall d'Hebron Research Institute, Universitat Autònoma de Barcelona and CIBERDEM, Barcelona, Spain,Autonomous University of Barcelona (författare)
  • Jain, DeepakLund University,Lunds universitet,Antigen presentation,Forskargrupper vid Lunds universitet,Medicinsk proteinvetenskap,Antigen Presentation,Lund University Research Groups,Medical Protein Science,Skåne University Hospital(Swepub:lu)med-dji (författare)
  • Simo, RafaelVall d'Hebron Research Institute, Universitat Autònoma de Barcelona and CIBERDEM, Barcelona, Spain,Autonomous University of Barcelona (författare)
  • Artner, IsabellaLund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Endokrin Celldifferentiering,Forskargrupper vid Lunds universitet,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Endocrine Cell Differentiation and Function,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-iba (författare)
  • Nilsson, Peter MLund University,Lunds universitet,Enheten för medicinens historia,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,History of Medicine,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-pni (författare)
  • Khalangot, Mykola D.Komisarenko Institute of Endocrinology and Metabolism, Kyiv, Ukraine; Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine,V. P. Komisarenko Institute of Endocrinology and Metabolism of the Ukraine Academy of Medical Sciences (författare)
  • Vaiserman, Alexander M.Laboratory of Epigenetics, Chebotarev Institute of Gerontology, Kyiv, Ukraine,Dmitry F. Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine (författare)
  • Chan, JulianaHong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong (författare)
  • Vaag, AllanSteno Diabetes Center Copenhagen, Copenhagen, Denmark(Swepub:lu)med-ava (författare)
  • Lyssenko, ValeriyaLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Skåne University Hospital,University of Bergen(Swepub:lu)endo-vly (författare)
  • Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, NorwayHong Kong Institute of Diabetes and Obesity, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Acta Ophthalmologica: John Wiley & Sons100:2, s. e539-e5451755-375X1755-3768

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