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Traffic-Related air...
Traffic-Related air pollution as a risk factor for dementia : no clear modifying effects of apoe ɛ4 in the betula cohort
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- Oudin, Anna (författare)
- Umeå University,Lund University,Lunds universitet,Umeå universitet,Avdelningen för hållbar hälsa,Department of Laboratory Medicine, Lund University, Lund, Sweden,Arcum,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Planetär hälsa,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Faculty of Medicine,Planetary Health,Lund University Research Groups
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- Andersson, John (författare)
- Umeå University,Umeå universitet,Institutionen för psykologi
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- Sundström, Anna (författare)
- Umeå University,Umeå universitet,Institutionen för psykologi
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- Nordin Adolfsson, Annelie (författare)
- Umeå University,Umeå universitet,Psykiatri
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- Oudin Åström, Daniel (författare)
- Umeå University,Umeå universitet,Avdelningen för hållbar hälsa
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- Adolfsson, Rolf (författare)
- Umeå University,Umeå universitet,Psykiatri,Arcum
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- Forsberg, Bertil, professor, 1956- (författare)
- Umeå University,Umeå universitet,Avdelningen för hållbar hälsa,Arcum
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- Nordin, Maria (författare)
- Umeå University,Umeå universitet,Institutionen för psykologi
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(creator_code:org_t)
- Amsterdam : IOS Press, 2021
- 2021
- Engelska.
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Ingår i: Alzheimer's disease and air pollution. - Amsterdam : IOS Press. - 2210-5727. - 9781643681597 - 9781643681580 ; , s. 357-364
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- It is widely known that the apolipoprotein E (APOE) ε4 allele imposes a higher risk for Alzheimer's disease (AD). Recent evidence suggests that exposure to air pollution is also a risk factor for AD, and results from a few studies indicate that the effect of air pollution on cognitive function and dementia is stronger in APOE ε4 carriers than in non-carriers. Air pollution and interaction with APOE ε4 on AD risk thus merits further attention. We studied dementia incidence over a 15-year period from the longitudinal Betula study in Northern Sweden. As a marker for long-term exposure to traffic-related air pollution, we used modelled annual mean nitrogen oxide levels at the residential address of the participants at start of follow-up. Nitrogen oxide correlate well with fine particulate air pollution levels in the study area. We had full data on air pollution, incidence of AD and vascular dementia (VaD), APOE ε4 carrier status, and relevant confounding factors for 1,567 participants. As expected, air pollution was rather clearly associated with dementia incidence. However, there was no evidence for a modifying effect by APOE ε4 on the association (p-value for interaction > 0.30 for both total dementia (AD+VaD) and AD). The results from this study do not imply that adverse effects of air pollution on dementia incidence is limited to, or stronger in, APOE ε4 carriers than in the total population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Air pollution
- Alzheimer's disease
- Apolipoprotein E
- Dementia
- Air pollution
- Alzheimer's disease
- apolipoprotein E
- dementia
Publikations- och innehållstyp
- ref (ämneskategori)
- kap (ämneskategori)
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