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Exploring the effec...
Exploring the effect of structure-based scaffold hopping on the inhibition of coxsackievirus a24v transduction by pentavalent n-acetylneuraminic acid conjugates
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- Johansson, Emil, 1985- (författare)
- Umeå universitet,Kemiska institutionen
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- Caraballo, Remi (författare)
- Umeå universitet,Kemiska institutionen
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- Hurdiss, Daniel L. (författare)
- Virology Section, Infectious Diseases and Immunology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands
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- Mistry, Nitesh (författare)
- Umeå universitet,Avdelningen för virologi
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- Andersson, C. David, 1978- (författare)
- Umeå universitet,Kemiska institutionen
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- Thompson, Rebecca F. (författare)
- Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom
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- Ranson, Neil A. (författare)
- Astbury Centre for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom
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- Zocher, Georg (författare)
- Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany
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- Stehle, Thilo (författare)
- Interfaculty Institute of Biochemistry, University of Tübingen, Tübingen, Germany; Department of Pediatrics, Vanderbilt University School of Medicine, TN, Nashville, United States
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- Arnberg, Niklas, 1987- (författare)
- Umeå universitet,Avdelningen för virologi
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- Elofsson, Mikael (författare)
- Umeå universitet,Kemiska institutionen
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(creator_code:org_t)
- 2021-08-05
- 2021
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 22:16
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Coxsackievirus A24 variant (CVA24v) is the primary causative agent of the highly contagious eye infection designated acute hemorrhagic conjunctivitis (AHC). It is solely responsible for two pandemics and several recurring outbreaks of the disease over the last decades, thus affecting millions of individuals throughout the world. To date, no antiviral agents or vaccines are available for combating this disease, and treatment is mainly supportive. CVA24v utilizes Neu5Ac-containing glycans as attachment receptors facilitating entry into host cells. We have previously reported that pentavalent Neu5Ac conjugates based on a glucose-scaffold inhibit CVA24v infection of human corneal epithelial cells. In this study, we report on the design and synthesis of scaffold-replaced pentavalent Neu5Ac conjugates and their effect on CVA24v cell transduction and the use of cryogenic electron microscopy (cryo-EM) to study the binding of these multivalent conjugates to CVA24v. The results presented here provide insights into the development of Neu5Ac-based inhibitors of CVA24v and, most significantly, the first application of cryo-EM to study the binding of a multivalent ligand to a lectin.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- 5-N-acetylneuraminic acid
- Antivirals
- Conjunctivitis
- Coxsackievirus A24v
- Cryo-EM
- Multivalency
- Sialic acid conjugates
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Johansson, Emil, ...
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Caraballo, Remi
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Hurdiss, Daniel ...
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Mistry, Nitesh
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Andersson, C. Da ...
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Thompson, Rebecc ...
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visa fler...
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Ranson, Neil A.
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Zocher, Georg
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Stehle, Thilo
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Arnberg, Niklas, ...
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Elofsson, Mikael
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