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Low serum 25-hydrox...
Low serum 25-hydroxyvitamin d level does not adversely affect bone turnover in prepubertal children
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Bilinski, Wojciech J. (författare)
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Szternel, Lukasz (författare)
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Siodmiak, Joanna (författare)
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- Paradowski, Przemyslaw T. (författare)
- Umeå universitet,Ortopedi,Sunderby Research Unit, Sunderby Central Hospital of Norrbotten, Luleå, Sweden; Faculty of Health Sciences, Collegium Medicum, Bydgoszcz, Nicolaus Copernicus University, Torun, Poland
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Domagalski, Krzysztof (författare)
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Sypniewska, Grazyna (författare)
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(creator_code:org_t)
- 2021-09-23
- 2021
- Engelska.
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Ingår i: Nutrients. - : MDPI. - 2072-6643. ; 13:10
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Both vitamin D and insulin-like growth factor 1 (IGF-1) play essential roles in bone metabolism and may interact during prepubertal bone accrual. We investigated the association of low serum 25-hydroxyvitamin D (25(OH)D) (<20 ng/mL) with the circulating bone turnover markers, when compared to their interaction with IGF-1. Subjects and Methods: Serum 25(OH)D, IGF-I, P1NP (N-terminal propeptide of type I procollagen), and CTX-1 (C-terminal telopeptide of type I collagen) were measured, and the bone turnover index (BTI) was calculated in 128 healthy children, aged 9–11 years. Results: Mean 25(OH)D concentration was 21.9 ± 4.9 ng/mL, but in 30.5% of participants it was <20 ng/mL (<50 nmol/L). We observed a trend for higher P1NP (p < 0.05) and IGF-1 (p = 0.08), towards lower 25(OH)D in tertiles. Levels of P1NP in the lowest 25(OH)D tertile (<20 ng/mL) were the highest, while CTX and BTI remained unchanged. Additionally, 25(OH)D negatively correlated with IGF-1, while the correlation with P1NP was not significant. A strong positive correlation of IGF-1 with P1NP and BTI but weak with CTX was observed. Low 25(OH)D (<20 ng/mL) explained 15% of the IGF-1 variance and 6% of the P1NP variance. Conclusions: Low levels of 25(OH)D do not unfavorably alter bone turnover. It seems that serum 25(OH)D level may not be an adequate predictor of bone turnover in children.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- 25-hydoxyvitamin D
- Bone mineral accrual
- Bone turnover markers
- Insulin-like growth factor 1
- Orthopaedics
- ortopedi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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