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Sökning: onr:"swepub:oai:DiVA.org:umu-18814" > Obstructive sleep a...

Obstructive sleep apnea is a risk factor for death in patients with stroke : a 10-year follow-up

Sahlin, Carin, 1953- (författare)
Umeå universitet,Lungmedicin
Sandberg, Olov (författare)
Umeå universitet,Geriatrik
Gustafson, Yngve (författare)
Umeå universitet,Geriatrik
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Bucht, Gösta (författare)
Umeå universitet,Geriatrik
Carlberg, Bo (författare)
Umeå universitet,Medicin
Stenlund, Hans (författare)
Umeå universitet,Epidemiologi och folkhälsovetenskap
Franklin, Karl (författare)
Umeå universitet,Lungmedicin
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 (creator_code:org_t)
Chicago : American medical association, 2008
2008
Engelska.
Ingår i: Archives of Internal Medicine. - Chicago : American medical association. - 0003-9926 .- 1538-3679. ; 168:3, s. 297-301
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  •  Background: Sleep apnea occurs frequently among stroke patients, but it is still unknown whether a diagnosis of sleep apnea is an independent risk factor for mortality. We aimed to investigate whether obstructive or central sleep apnea was related to a reduced long-term survival among stroke patients.Methods: One hundred and thirty-two of 151 patients admitted for in-hospital stroke rehabilitation in the catchment area of Umeå from 1 April 1995 to 1 May 1997 underwent overnight sleep apnea recordings at 23 ± 8 days after onset of stroke. All patients were followed-up prospectively for a mean (SD) of 10.0 ± 0.6 years, with death as the primary outcome and no one was lost to follow-up. Obstructive sleep apnea was defined when the obstructive apnea-hypopnea index was over 15 and central sleep apnea when the central apnea-hypopnea index was over 15. Patients with an obstructive and a central apnea-hypopnea index below 15 served as controls.Results: Of 132 enrolled patients, 116 had died at follow-up. The risk of death was higher among the 23 patients with obstructive sleep apnea than controls (adjusted hazard ratio, 1.76; 95% confidence interval 1.05 to 2.95, p=0.03), independent of age, gender, body-mass index, smoking, hypertension, diabetes mellitus, atrial fibrillation, mini-mental state examination and Barthel activity of daily living There was no difference in mortality between the 28 patients with central sleep apnea and controls (adjusted hazard ratio, 1.07; 95 percent confidence interval 0.65 to 1.76, p=0.053).Conclusions: Stroke patients with obstructive sleep apnea run an increased risk of early death. Central sleep apnea was not related to early death among the present patients.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Allmänmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- General Practice (hsv//eng)

Nyckelord

obstructive sleep apnéa
stroke
death
positive airway pressure
Cheyne-Stokes respiration
breathing disorders
ischemic stroke
1st-ever stroke
prognosis
disease
night
Cardiovascular medicine
Kardiovaskulär medicin
lungmedicin
Lung Medicine

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