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Killing of Gram-neg...
Killing of Gram-negative and Gram-positive bacteria by a bifunctional cell wall-targeting T6SS effector
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- Le, Nguyen-Hung (författare)
- Department of Molecular Microbiology, Washington University in St. Louis School of Medicine, MO, St. Louis, United States
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- Pinedo, Victor (författare)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Lopez, Juvenal (författare)
- Department of Molecular Microbiology, Washington University in St. Louis School of Medicine, MO, St. Louis, United States
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- Cava, Felipe (författare)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Feldman, Mario F. (författare)
- Department of Molecular Microbiology, Washington University in St. Louis School of Medicine, MO, St. Louis, United States
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Department of Molecular Microbiology, Washington University in St Louis School of Medicine, MO, St. Louis, United States Molekylär Infektionsmedicin, Sverige (MIMS) (creator_code:org_t)
- 2021-09-29
- 2021
- Engelska.
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Science. - 0027-8424 .- 1091-6490. ; 118:40
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The type VI secretion system (T6SS) is a powerful tool deployed by Gram-negative bacteria to antagonize neighboring organisms. Here, we report that Acinetobacter baumannii ATCC 17978 (Ab17978) secretes D-lysine (D-Lys), increasing the extracellular pH and enhancing the peptidoglycanase activity of the T6SS effector Tse4. This synergistic effect of D-Lys on Tse4 activity enables Ab17978 to out-compete Gram-negative bacterial competitors, demonstrating that bacteria can modify their microenvironment to increase their fitness during bacterial warfare. Remarkably, this lethal combination also results in T6SS-mediated killing of Gram-positive bacteria. Further characterization revealed that Tse4 is a bifunctional enzyme consisting of both lytic transglycosylase and endopeptidase activities, thus representing a family of modularly organized T6SS peptidoglycan-degrading effectors with an unprecedented impact in antagonistic bacterial interactions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Effector
- Microenvironment
- Peptidoglycan
- T6SS
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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