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Non-invasive Urine ...
Non-invasive Urine Test for Molecular Classification of Clinical Significance in Newly Diagnosed Prostate Cancer Patients
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- Guo, Jinan (författare)
- Jinan Univ, Clin Med Coll 2, Shenzhen People S Hosp, Shenzhen, Peoples R China.;Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China.;Shenzhen Urol Minimally Invas Engn Ctr, Shenzhen, Peoples R China.;Clin Med Res Ctr, Shenzhen Publ Serv Platform Tumor Precis Med & Mo, Shenzhen, Peoples R China.,Jinan University
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- Zhang, Xuhui (författare)
- Inst Basic Med Sci, Dept Biodiag, Beijing, Peoples R China.,Beijing Institute of Basic Medical Sciences
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- Xia, Taolin (författare)
- Foshan First Peoples Hosp, Dept Urol, Foshan, Peoples R China.,Foshan First People’s Hospital
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- Johnson, Heather (författare)
- Olympia Diagnost Inc, Sunnyvale, CA USA.,Olympia Diagnostics Inc.
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- Feng, Xiaoyan (författare)
- Inst Basic Med Sci, Dept Biodiag, Beijing, Peoples R China.,Beijing Institute of Basic Medical Sciences
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- Simoulis, Athanasios (författare)
- Skane Univ Hosp, Dept Clin Pathol & Cytol, Malmo, Sweden.,Skåne University Hospital
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- Wu, Alan H. B. (författare)
- San Francisco Gen Hosp, Clin Labs, San Francisco, CA 94110 USA.,San Francisco General Hospital
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- Li, Fei (författare)
- Southern Med Univ, Nanfang Hosp, Dept Urol, Guangzhou, Peoples R China.,Southern Medical University
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- Tan, Wanlong (författare)
- Southern Med Univ, Nanfang Hosp, Dept Urol, Guangzhou, Peoples R China.,Southern Medical University
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- Johnson, Allan (författare)
- Kinet Real, Santa Clara, CA USA.,Kinetic Reality
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- Dizeyi, Nishtman (författare)
- Lund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Urologi, Malmö (Abrahamsson),Forskargrupper vid Lunds universitet,Department of Translational Medicine,Faculty of Medicine,Urological research, Malmö,Lund University Research Groups
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- Abrahamsson, Per Anders (författare)
- Lund University,Lunds universitet,Urologi, Malmö (Abrahamsson),Forskargrupper vid Lunds universitet,Urological research, Malmö,Lund University Research Groups
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- Kenner, Lukas (författare)
- Med Univ Vienna, Dept Expt Pathol, Vienna, Austria.;Univ Vet Med, Unit Lab Anim Pathol, Vienna, Austria.,Medical University of Vienna
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- Xiao, Kefeng (författare)
- Jinan Univ, Clin Med Coll 2, Shenzhen People S Hosp, Shenzhen, Peoples R China.;Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China.;Shenzhen Urol Minimally Invas Engn Ctr, Shenzhen, Peoples R China.;Clin Med Res Ctr, Shenzhen Publ Serv Platform Tumor Precis Med & Mo, Shenzhen, Peoples R China.,Jinan University
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- Zhang, Heqiu (författare)
- Inst Basic Med Sci, Dept Biodiag, Beijing, Peoples R China.,Beijing Institute of Basic Medical Sciences
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- Chen, Lingwu (författare)
- Sun Yat Sen Univ, Affiliated Hosp 1, Dept Urol, Guangzhou, Peoples R China.,First Affiliated Hospital of Sun Yat-sen University
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- Zou, Chang (författare)
- Jinan Univ, Clin Med Coll 2, Shenzhen People S Hosp, Shenzhen, Peoples R China.;Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China.;Shenzhen Urol Minimally Invas Engn Ctr, Shenzhen, Peoples R China.;Clin Med Res Ctr, Shenzhen Publ Serv Platform Tumor Precis Med & Mo, Shenzhen, Peoples R China.;Southwest Med Univ, Sch Pharm, Educ Minist, Key Lab Med Electrophysiol, Luzhou, Peoples R China.,Jinan University
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- Persson, Jenny L., Professor (författare)
- Umeå University,Malmö University,Malmö universitet,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Biomedical Sciences, Malmö University, Malmö, Sweden; Division of Experimental Cancer Research, Department of Translational Medicine, Lund University, Malmö, Sweden,Institutionen för biomedicinsk vetenskap (BMV),Umea Univ, Dept Mol Biol, Umea, Sweden.; Lund Univ, Dept Translat Med, Div Expt Canc Res, Malmo, Sweden.
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Jinan Univ, Clin Med Coll 2, Shenzhen People S Hosp, Shenzhen, Peoples R China;Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China.;Shenzhen Urol Minimally Invas Engn Ctr, Shenzhen, Peoples R China.;Clin Med Res Ctr, Shenzhen Publ Serv Platform Tumor Precis Med & Mo, Shenzhen, Peoples R China. Jinan University (creator_code:org_t)
- 2021-09-14
- 2021
- Engelska.
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Ingår i: Frontiers in Medicine. - : Frontiers Media S.A.. - 2296-858X. ; 8
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://www.frontier...
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https://mau.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Objective: To avoid over-treatment of low-risk prostate cancer patients, it is important to identify clinically significant and insignificant cancer for treatment decision-making. However, no accurate test is currently available.Methods: To address this unmet medical need, we developed a novel gene classifier to distinguish clinically significant and insignificant cancer, which were classified based on the National Comprehensive Cancer Network risk stratification guidelines. A non-invasive urine test was developed using quantitative mRNA expression data of 24 genes in the classifier with an algorithm to stratify the clinical significance of the cancer. Two independent, multicenter, retrospective and prospective studies were conducted to assess the diagnostic performance of the 24-Gene Classifier and the current clinicopathological measures by univariate and multivariate logistic regression and discriminant analysis. In addition, assessments were performed in various Gleason grades/ISUP Grade Groups.Results: The results showed high diagnostic accuracy of the 24-Gene Classifier with an AUC of 0.917 (95% CI 0.892-0.942) in the retrospective cohort (n = 520), AUC of 0.959 (95% CI 0.935-0.983) in the prospective cohort (n = 207), and AUC of 0.930 (95% 0.912-CI 0.947) in the combination cohort (n = 727). Univariate and multivariate analysis showed that the 24-Gene Classifier was more accurate than cancer stage, Gleason score, and PSA, especially in the low/intermediate-grade/ISUP Grade Group 1-3 cancer subgroups.Conclusions: The 24-Gene Classifier urine test is an accurate and non-invasive liquid biopsy method for identifying clinically significant prostate cancer in newly diagnosed cancer patients. It has the potential to improve prostate cancer treatment decisions and active surveillance.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- active surveillance
- clinically significant prostate cancer
- gene panel
- liquid biopsy
- prostate cancer
- prostate cancer risk
- urine test
- medicin
- Medicine
- active surveillance
- clinically significant prostate cancer
- gene panel
- liquid biopsy
- prostate cancer
- prostate cancer risk
- urine test
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Guo, Jinan
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Zhang, Xuhui
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Xia, Taolin
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Johnson, Heather
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Feng, Xiaoyan
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Simoulis, Athana ...
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visa fler...
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Wu, Alan H. B.
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Li, Fei
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Tan, Wanlong
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Johnson, Allan
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Dizeyi, Nishtman
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Abrahamsson, Per ...
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Kenner, Lukas
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Xiao, Kefeng
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Zhang, Heqiu
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Chen, Lingwu
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Zou, Chang
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Persson, Jenny L ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
- Artiklar i publikationen
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Frontiers in Med ...
- Av lärosätet
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Umeå universitet
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Malmö universitet
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Lunds universitet