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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 14950naa a2201213 4500 | |
| 001 | oai:DiVA.org:umu-190589 | |
| 003 | SwePub | |
| 008 | 211222s2020 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:235047832 | |
| 009 | oai:DiVA.org:uu-479461 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1905892 URI |
| 024 | 7 | a https://doi.org/10.1016/j.xhgg.2020.1000102 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2350478322 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4794612 URI |
| 040 | a (SwePub)umud (SwePub)kid (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Jarvik, Gail P.u University of Washington Medical Center, WA, Seattle, United States,Univ Washington Med Ctr, Seattle, WA 98195 USA.4 aut |
| 245 | 1 0 | a Hemochromatosis risk genotype is not associated with colorectal cancer or age at its diagnosis |
| 264 | 1 | b Cell press,c 2020 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Homozygotes for the higher penetrance hemochromatosis risk allele, HFE c.845G>A (p.Cys282Tyr, or C282Y), have been reported to be at a 2- to 3-fold increased risk for colorectal cancer (CRC). These results have been reported for small sample size studies with no information about age at diagnosis for CRC. An association with age at diagnosis might alter CRC screening recommendations. We analyzed two large European ancestry datasets to assess the association of HFE genotype with CRC risk and age at CRC diagnosis. The first dataset included 59,733 CRC or advanced adenoma cases and 72,351 controls from a CRC epidemiological study consortium. The second dataset included 13,564 self-reported CRC cases and 2,880,218 controls from the personal genetics company, 23andMe. No association of the common hereditary hemochromatosis (HH) risk genotype and CRC was found in either dataset. The odds ratios (ORs) for the association of CRC and HFE C282Y homozygosity were 1.08 (95% confidence interval [CI], 0.91–1.29; p = 0.4) and 1.01 (95% CI, 0.78–1.31, p = 0.9) in the two cohorts, respectively. Age at CRC diagnosis also did not differ by HFE C282Y/C282Y genotype in either dataset. These results indicate no increased CRC risk in individuals with HH genotypes and suggest that persons with HH risk genotypes can follow population screening recommendations for CRC. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng |
| 653 | a age of onset | |
| 653 | a colon cancer | |
| 653 | a ferritin | |
| 653 | a genetic | |
| 653 | a HFE gene | |
| 653 | a iron | |
| 653 | a population screening | |
| 700 | 1 | a Wang, Xiaoliangu Fred Hutchinson Cancer Research Center, WA, Seattle, United States,Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.4 aut |
| 700 | 1 | a Fontanillas, Pierreu 23andMe, CA, Sunnyvale, United States4 aut |
| 700 | 1 | a Kim, Estheru 23andMe, CA, Sunnyvale, United States4 aut |
| 700 | 1 | a Chanprasert, Sirisaku University of Washington Medical Center, WA, Seattle, United States,Univ Washington Med Ctr, Seattle, WA 98195 USA.4 aut |
| 700 | 1 | a Gordon, Adam S.u Northwestern University, IL, Evanston, United States,Northwestern Univ, Evanston, IL USA.4 aut |
| 700 | 1 | a Bastarache, Lisau Vanderbilt Medical Center, GA, Atlanta, United States,Vanderbilt Univ Sch Med, Atlanta, GA USA.4 aut |
| 700 | 1 | a Kowdley, Kris V.u Liver Institute Northwest, WA, Seattle, United States,Liver Inst Northwest, Seattle, WA USA.4 aut |
| 700 | 1 | a Harrison, Tabithau Fred Hutchinson Cancer Research Center, WA, Seattle, United States,Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.4 aut |
| 700 | 1 | a Rosenthal, Elisabeth A.u University of Washington Medical Center, WA, Seattle, United States,Univ Washington Med Ctr, Seattle, WA 98195 USA.4 aut |
| 700 | 1 | a Stanaway, Ian B.u University of Washington Medical Center, WA, Seattle, United States,Univ Washington Med Ctr, Seattle, WA 98195 USA.4 aut |
| 700 | 1 | a Bézieau, Stéphaneu Centre Hospitalier Universitaire (CHU) Nantes, France,Ctr Hosp Univ CHU Nantes, Nantes, France.,City Hope Comprehens Canc Ctr, Duarte, CA USA.,City of Hope Comprehensive Cancer Center, CA, Duarte, United States4 aut |
| 700 | 1 | a Weinstein, Stephanie J.u National Cancer Institute, National Institutes of Health, MD, Bethesda, United States,NCI, NIH, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Newcomb, Polly A.u Fred Hutchinson Cancer Research Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States,Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA.4 aut |
| 700 | 1 | a Casey, Grahamu University of Virginia, VA, Charlottesville, United States,Univ Virginia, Charlottesville, VA USA.4 aut |
| 700 | 1 | a Platz, Elizabeth A.u Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States,Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.4 aut |
| 700 | 1 | a Visvanathan, Kalau Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States,Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.4 aut |
| 700 | 1 | a Le Marchand, Loicu University of Hawaii Cancer Center, HI, Honolulu, United States,Univ Hawaii Canc Ctr, Honolulu, HI USA.4 aut |
| 700 | 1 | a Ulrich, Cornelia M.u University of Utah, UT, Salt Lake City, United States,Univ Utah, Salt Lake City, UT USA.4 aut |
| 700 | 1 | a Hardikar, Sheetalu University of Utah, UT, Salt Lake City, United States,Univ Utah, Salt Lake City, UT USA.4 aut |
| 700 | 1 | a Li, Christopher I.u Fred Hutchinson Cancer Research Center, WA, Seattle, United States,Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.,Univ Virginia, Charlottesville, VA USA.,University of Virginia, VA, Charlottesville, United States4 aut |
| 700 | 1 | a van Duijnhoven, Franzel J.B.u Division of Human Nutrition and Health, Wageningen University and Research Wageningen, Netherlands,Wageningen Univ & Res Wageningen, Div Human Nutr & Hlth, Wageningen, Netherlands.4 aut |
| 700 | 1 | a Gsur, Andreau Medical University Vienna, Vienna, Austria,Med Univ Vienna, Vienna, Austria.4 aut |
| 700 | 1 | a Campbell, Peter T.u American Cancer Society, GA, Atlanta, United States,Amer Canc Soc, Atlanta, GA 30329 USA.4 aut |
| 700 | 1 | a Moreno, Victoru Oncology Data Analytics Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP) and Department of Clinical Sciences, Faculty of Medicine, University of Barcelona (UB), L'Hospitalet, Barcelona, Spain,Univ Barcelona UB, Oncol Data Analyt Program, Catalan Inst Oncol ICO,Fac Med, Bellvitge Biomed Res Inst IDIBELL,Consortium Biom, Barcelona 08908, Spain.;Univ Barcelona UB, Fac Med, Dept Clin Sci, Barcelona 08908, Spain.4 aut |
| 700 | 1 | a Vodička, Pavelu Institute of Experimental Medicine, Czech Academy of Sciences, Biomedical Center, Medical Faculty Pilsen and 1st Medical Faculty, Charles University, Prague, Czech Republic,Charles Univ Prague, Inst Expt Med, Czech Acad Sci, Biomed Ctr,Med Fac Pilsen, Prague, Czech Republic.;Charles Univ Prague, Med Fac 1, Prague, Czech Republic.4 aut |
| 700 | 1 | a Brenner, Hermannu German Cancer Research Center (DKFZ), Heidelberg, Germany,German Canc Res Ctr, Heidelberg, Germany.4 aut |
| 700 | 1 | a Chang-Claude, Jennyu German Cancer Research Center (DKFZ), Heidelberg, Germany,German Canc Res Ctr, Heidelberg, Germany.4 aut |
| 700 | 1 | a Hoffmeister, Michaelu German Cancer Research Center (DKFZ), Heidelberg, Germany,German Canc Res Ctr, Heidelberg, Germany.4 aut |
| 700 | 1 | a Slattery, Martha L.u University of Utah, UT, Salt Lake City, United States,Univ Utah, Salt Lake City, UT USA.4 aut |
| 700 | 1 | a Gunter, Marc J.u Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), Lyon, France,Int Agcy Res Canc IARC WHO, Nutr & Metab Sect, Lyon, France.4 aut |
| 700 | 1 | a Aglago, Elom K.u Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), Lyon, France,Int Agcy Res Canc IARC WHO, Nutr & Metab Sect, Lyon, France.4 aut |
| 700 | 1 | a Castellví-Bel, Sergiu Gastroenterology Department, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Hospital Clínic, Universitat de Barcelona, Barcelona, Spain,Univ Barcelona, Hosp Clin, Gastroenterol Dept,Ctr Invest Biomed Red Enfermed, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.4 aut |
| 700 | 1 | a Kweon, Sun-Seogu Chonnam National University Medical School, Gwangju, South Korea,Chonnam Natl Univ Med Sch, Gwangju, South Korea.4 aut |
| 700 | 1 | a Chan, Andrew T.u Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States,Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.;Harvard Med Sch, Boston, MA 02115 USA.4 aut |
| 700 | 1 | a Li, Liu University of Virginia, VA, Charlottesville, United States4 aut |
| 700 | 1 | a Zheng, Weiu Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, TN, Nashville, United States,Vanderbilt Univ Sch Med, Vanderbilt Epidemiol Ctr, Vanderbilt Ingram Canc Ctr, Div Epidemiol, Nashville, TN USA.4 aut |
| 700 | 1 | a Bishop, D. Timothyu University of Leeds, UK, Leeds, United Kingdom,Univ Leeds, Leeds, W Yorkshire, England.4 aut |
| 700 | 1 | a Giles, Graham G.u Cancer Council Victoria, VIC, Melbourne, Australia; University of Melbourne, VIC, Melbourne, Australia; Monash University, VIC, Melbourne, Australia,Canc Council Victoria, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne, Vic, Australia.;Monash Univ, Melbourne, Vic, Australia.4 aut |
| 700 | 1 | a Rennert, Gadu Lady Davis Carmel Medical Center, Haifa, Israel,Lady Davis Carmel Med Ctr, Haifa, Israel.4 aut |
| 700 | 1 | a Offit, Kennethu Memorial Sloan Kettering Cancer Center, NY, New York, United States,Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.4 aut |
| 700 | 1 | a Keku, Temitope O.u University of North Carolina, NC, Chapel Hill, United States,Univ N Carolina, Chapel Hill, NC USA.4 aut |
| 700 | 1 | a Woods, Michael O.u Memorial University of Newfoundland, NL, St. John's, Canada,Mem Univ Newfoundland, St John, NL, Canada.4 aut |
| 700 | 1 | a Hampe, Jochenu Technische Universität Dresden (TU Dresden), Dresden, Germany,Tech Univ Dresden TU Dresden, Dresden, Germany.4 aut |
| 700 | 1 | a van Guelpen, Bethanyu Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi,Umeå Univ, Dept Radiat Sci, Oncol, Umeå, Sweden.;Umeå Univ, Wallenberg Ctr Mol Med, Umeå, Sweden.4 aut0 (Swepub:umu)beyvan99 |
| 700 | 1 | a Gallinger, Steven J.u University of Toronto, ON, Toronto, Canada,Univ Toronto, Toronto, ON, Canada.4 aut |
| 700 | 1 | a de la Chapelle, Albertu The Ohio State University, OH, Columbus, United States,Ohio State Univ, Columbus, OH 43210 USA.4 aut |
| 700 | 1 | a Hampel, Heatheru The Ohio State University, OH, Columbus, United States,Ohio State Univ, Columbus, OH 43210 USA.,Univ Southern Calif, Los Angeles, CA USA.,University of Southern California, CA, Los Angeles, United States4 aut |
| 700 | 1 | a Berndt, Sonja I.u National Cancer Institute, National Institutes of Health, MD, Bethesda, United States,NCI, NIH, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Tangen, Catherine M.u Fred Hutchinson Cancer Research Center, WA, Seattle, United States,Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.4 aut |
| 700 | 1 | a Lindblom, Annikau Karolinska Institutet,Karolinska Univ Hosp, Stockholm, Sweden.,Karolinska University Hospital, Stockholm, Sweden4 aut |
| 700 | 1 | a Wolk, Alicjau Uppsala universitet,Karolinska Institutet,Ortopedi,Medicinsk epidemiologi,Karolinska Inst, Stockholm, Sweden.,Karolinska Institutet, Stockholm, Sweden; Uppsala University, Uppsala, Sweden4 aut0 (Swepub:uu)alwol516 |
| 700 | 1 | a Burnett-Hartman, Andreau Kaiser Permanente Colorado, CO, Denver, United States,Kaiser Permanente Colorado, Denver, CO USA.4 aut |
| 700 | 1 | a Wu, Anna H.u University of Southern California, CA, Los Angeles, United States4 aut |
| 700 | 1 | a White, Emilyu Fred Hutchinson Cancer Research Center, WA, Seattle, United States,Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.4 aut |
| 700 | 1 | a Gruber, Stephen B.u City of Hope Comprehensive Cancer Center, CA, Duarte, United States4 aut |
| 700 | 1 | a Jenkins, Mark A.u Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, VIC, Australia,Univ Melbourne, Ctr Epidemiol & Biostat, Sch Populat & Global Hlth, Melbourne, Vic, Australia.4 aut |
| 700 | 1 | a Mountain, Joannau 23andMe, CA, Sunnyvale, United States4 aut |
| 700 | 1 | a Peters, Ulrikeu Fred Hutchinson Cancer Research Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Medicine, WA, Seattle, United States,Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Dept Epidemiol, Sch Med, Seattle, WA 98195 USA.4 aut |
| 700 | 1 | a Crosslin, David R.u University of Washington Medical Center, WA, Seattle, United States,Univ Washington Med Ctr, Seattle, WA 98195 USA.4 aut |
| 710 | 2 | a University of Washington Medical Center, WA, Seattle, United Statesb Univ Washington Med Ctr, Seattle, WA 98195 USA.4 org |
| 773 | 0 | t Human Genetics and Genomics Advancesd : Cell pressg 1:1q 1:1x 2666-2477 |
| 856 | 4 | u https://doi.org/10.1016/j.xhgg.2020.100010y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1622489/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://doi.org/10.1016/j.xhgg.2020.100010 |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1679076/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-190589 |
| 856 | 4 8 | u https://doi.org/10.1016/j.xhgg.2020.100010 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:235047832 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-479461 |
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