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Anti-CD74 IgA autoa...
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Do, LanUmeå University,Umeå universitet,Reumatologi
(författare)
Anti-CD74 IgA autoantibodies in radiographic axial spondyloarthritis : a longitudinal Swedish study
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2020-12-28
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Oxford University Press,2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-191231
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191231URI
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https://doi.org/10.1093/rheumatology/keaa882DOI
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https://lup.lub.lu.se/record/db01ea10-de13-49e7-b1a9-9e65acff19b5URI
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https://gup.ub.gu.se/publication/300688URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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OBJECTIVES: Antibodies against anti-CD74 are related to axial spondyloarthritis (axSpA). The objectives were (i) to study IgA anti-CD74 in radiographic (r)-axSpA patients in the Backbone cohort and to calculate the sensitivity and specificity of anti-CD74, (ii) to study the fluctuation of IgA anti-CD74 levels in prospectively collected samples, and (iii) to explore the relation between IgA anti-CD74 and radiographic spinal changes.METHODS: IgA anti-CD74 was analysed by ELISA in 155 patients with r-axSpA and age- and sex-matched controls. BASDAI, ASDAS, BASFI and BASMI were assessed and spinal radiographs were scored for r-axSpA-related changes with mSASSS. Previously donated samples, before inclusion in the Backbone study, were identified in the Medical Biobank of Northern Sweden.RESULTS: A total of 155 patients comprising 69% men and 31% women, age [mean (s.d.)] 55.5 (11.4) years and 152 (98.1%) HLA-B27 positive, were included. The plasma level of IgA anti-CD74 was significantly higher in the patients [median (interquartile range), 12.9 (7.9-17.9) U/ml] compared with controls [10.9 (7.2-14.6) U/ml, P = 0.003]. IgA anti-CD74 was above the cut-off level of 20 U/ml in 36/155 (23.2%) patients and in 15/151 (9.9%) controls (P = 0.002). Multivariable logistic regression analyses revealed ≥1 syndesmophyte associated with IgA anti-CD74 (odds ratio 5.64; 95% CI: 1.02, 35.58; P = 0.048) adjusted for hsCRP, smoking, BMI, sex and age. No distinct pattern of IgA anti-CD74 over time was revealed.CONCLUSION: Plasma levels of IgA anti-CD74 were increased in r-axSpA and independently associated with radiographic spinal changes, which suggests that IgA anti-CD74 could play a role in the pathogenies of r-axSpA.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Granåsen, Gabriel,1980-Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)galgrn00
(författare)
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Hellman, Urban,1966-Umeå University,Umeå universitet,Reumatologi(Swepub:umu)urhe0001
(författare)
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Lejon, Kristina,1967-Umeå University,Umeå universitet,Immunologi/immunkemi(Swepub:umu)krle0001
(författare)
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Geijer, MatsLund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Sahlgrenska University Hospital,Sahlgrenska Academy(Swepub:lu)med-mge
(författare)
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Baraliakos, XenofonDepartment of Biochemistry, Ruhr-Universität Bochum, Bochum, Germany
(författare)
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Witte, TorstenDepartment of Rheumatology and Clinical Immunology, Medical University Hannover, Hannover, Germany,Hannover Medical School
(författare)
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Forsblad-d'Elia, HelenaGothenburg University,Göteborgs universitet,Umeå University,Umeå universitet,Reumatologi,Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Rheumatology, Sahlgrenska University Hospital, Region Västra Götaland, Gothenburg, Sweden,Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning,Institute of Medicine, Department of Rheumatology and Inflammation Research(Swepub:gu)xforhe
(författare)
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Umeå universitetReumatologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Rheumatology: Oxford University Press60:9, s. 4085-40931462-03241462-03321310-0505
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Geijer, Mats
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