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Lack of Association...
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Maple-Grødem, JodiThe Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway
(författare)
Lack of Association between GBA Mutations and Motor Complications in European and American Parkinson's Disease Cohorts
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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IOS Press,2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-191319
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-191319URI
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https://doi.org/10.3233/jpd-212657DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background: Motor complications are a consequence of the chronic dopaminergic treatment of Parkinson's disease (PD) and include levodopa-induced dyskinesia (LIDs) and motor fluctuations (MF). Currently, evidence is on lacking whether patients with GBA-associated PD differ in their risk of developing motor complications compared to the general PD population.Objective: To evaluate the association of GBA carrier status with the development of LIDS and MFs from early PD.Methods: Motor complications were recorded prospectively in 884 patients with PD from four longitudinal cohorts using part IV of the UPDRS or MDS-UPDRS. Subjects were followed for up to 11 years and the associations of GBA mutations with the development of motor complications were assessed using parametric accelerated failure time models.Results: In 439 patients from Europe, GBA mutations were detected in 53 (12.1%) patients and a total of 168 cases of LIDs and 258 cases of MF were observed. GBA carrier status was not associated with the time to develop LIDs (HR 0.78, 95%CI 0.47 to 1.26, p = 0.30) or MF (HR 1.19, 95%CI 0.84 to 1.70, p = 0.33). In the American cohorts, GBA mutations were detected in 36 (8.1%) patients and GBA carrier status was also not associated with the progression to LIDs (HR 1.08, 95%CI 0.55 to 2.14, p = 0.82) or MF (HR 1.22, 95%CI 0.74 to 2.04, p = 0.43).Conclusion: This study does not provide evidence that GBA-carrier status is associated with a higher risk of developing motor complications. Publication of studies with null results is vital to develop an accurate summary of the clinical features that impact patients with GBA-associated PD.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Paul, Kimberly C.Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States
(författare)
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Dalen, IngvildDepartment of Research, Section of Biostatistics, Stavanger University Hospital, Stavanger, Norway
(författare)
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Ngo, Kathie J.Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States
(författare)
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Wong, DariceDepartment of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States; Clinical Neurogenomics Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA, Los Angeles, United States
(författare)
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Macleod, Angus D.Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom
(författare)
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Counsell, Carl E.Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, United Kingdom
(författare)
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Bäckström, David C,M.D.1978-Umeå universitet,Neurovetenskaper,Department of Neurology, And Department of Neuroscience, Yale University School of Medicine, CT, New Haven, United States(Swepub:umu)dadbam02
(författare)
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Forsgren, LarsUmeå universitet,Neurovetenskaper(Swepub:umu)lafo0001
(författare)
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Tysnes, Ole-BjørnDepartment of Neurology, Haukeland University Hospital, Bergen, Norway; Department of Clinical Medicine, University of Bergen, Bergen, Norway
(författare)
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Kusters, Cynthia D.J.Department of Human Genetics, University of California Los Angeles, CA, Los Angeles, United States
(författare)
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Fogel, Brent L.Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States; Clinical Neurogenomics Research Center, David Geffen School of Medicine, University of California, Los Angeles, CA, Los Angeles, United States
(författare)
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Bronstein, Jeff M.Department of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States
(författare)
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Ritz, BeateDepartment of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States; Department of Epidemiology, UCLA Fielding School of Public Health, CA, Los Angeles, United States; Department of Biostatistics, UCLA Fielding School of Public Health, CA, Los Angeles, United States
(författare)
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Alves, GuidoThe Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, Norway; Department of Neurology, Stavanger University Hospital, Stavanger, Norway
(författare)
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The Norwegian Centre for Movement Disorders, Stavanger University Hospital, Stavanger, Norway; Department of Chemistry, Bioscience and Environmental Engineering, University of Stavanger, Stavanger, NorwayDepartment of Neurology, David Geffen School of Medicine, CA, Los Angeles, United States
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Parkinson's Disease: IOS Press11:4, s. 1569-15781877-71711877-718X
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Till lärosätets databas
- Av författaren/redakt...
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Maple-Grødem, Jo ...
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Paul, Kimberly C ...
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Dalen, Ingvild
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Ngo, Kathie J.
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Wong, Darice
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Macleod, Angus D ...
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visa fler...
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Counsell, Carl E ...
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Bäckström, David ...
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Forsgren, Lars
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Tysnes, Ole-Bjør ...
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Kusters, Cynthia ...
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Fogel, Brent L.
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Bronstein, Jeff ...
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Ritz, Beate
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Alves, Guido
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- MEDICIN OCH HÄLSOVETENSKAP
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