Sökning: onr:"swepub:oai:DiVA.org:umu-191349" >
Metabolic signature...
Metabolic signatures of healthy lifestyle patterns and colorectal cancer risk in a European cohort
-
- Rothwell, Joseph A. (författare)
- Centre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France; International Agency for Research on Cancer, Lyon, France
-
- Murphy, Neil (författare)
- International Agency for Research on Cancer, Lyon, France
-
- Bešević, Jelena (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
-
visa fler...
-
- Kliemann, Nathalie (författare)
- International Agency for Research on Cancer, Lyon, France
-
- Jenab, Mazda (författare)
- International Agency for Research on Cancer, Lyon, France
-
- Ferrari, Pietro (författare)
- International Agency for Research on Cancer, Lyon, France
-
- Achaintre, David (författare)
- International Agency for Research on Cancer, Lyon, France
-
- Gicquiau, Audrey (författare)
- International Agency for Research on Cancer, Lyon, France
-
- Vozar, Béatrice (författare)
- International Agency for Research on Cancer, Lyon, France
-
- Scalbert, Augustin (författare)
- International Agency for Research on Cancer, Lyon, France
-
- Huybrechts, Inge (författare)
- International Agency for Research on Cancer, Lyon, France
-
- Freisling, Heinz (författare)
- International Agency for Research on Cancer, Lyon, France
-
- Prehn, Cornelia (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
-
- Adamski, Jerzy (författare)
- Research Unit, Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, Neuherberg, Germany; Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Neuherberg, Germany
-
- Cross, Amanda J. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
-
- Pala, Valeria Maria (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
-
- Boutron-Ruault, Marie-Christine (författare)
- Centre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France
-
- Dahm, Christina C. (författare)
- Department of Public Health, Aarhus University, Aarhus C, Denmark
-
- Overvad, Kim (författare)
- Department of Public Health, Aarhus University, Aarhus C, Denmark
-
- Gram, Inger Torhild (författare)
- Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
-
- Sandanger, Torkjel M. (författare)
- Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
-
- Skeie, Guri (författare)
- Faculty of Health Sciences, Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway
-
- Jakszyn, Paula (författare)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Barcelona, Spain; Blanquerna School of Health Sciences, Ramon Llull University, Barcelona, Spain
-
- Tsilidis, Kostas K. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
-
- Aleksandrova, Krasimira (författare)
- Nutrition, Immunity and Metabolism Group, Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
-
- Schulze, Matthias B. (författare)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
-
- Hughes, David J. (författare)
- School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Dublin, Ireland
-
- van Guelpen, Bethany (författare)
- Umeå universitet,Onkologi
-
- Bodén, Stina (författare)
- Umeå universitet,Onkologi
-
- Sánchez, Maria-José (författare)
- CIBER Epidemiología y Salud Pública, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
-
- Schmidt, Julie A. (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
-
- Katzke, Verena (författare)
- Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts, Heidelberg, Germany
-
- Kühn, Tilman (författare)
- Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts, Heidelberg, Germany
-
- Colorado-Yohar, Sandra (författare)
- Department of Epidemiology, Murcia Regional Health Council, Instituto Murciano de Investigatión Biomédica (IMIB)–Arrixaca, Murcia, Spain; CIBER Epidemiología y Salud Pública, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
-
- Tumino, Rosario (författare)
- Cancer Registry and Histopathology Department, Provincial Health Authority, Ragusa, Italy
-
- Bueno-de-Mesquita, Bas (författare)
- Department for Determinants of Chronic Diseases, National Institute for Public Health and the Environment, The Netherlands, BA Bilthoven, Netherlands
-
- Vineis, Paolo (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Italian Institute of Technology, Genova, Italy
-
- Masala, Giovanna (författare)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network–Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO), Florence, Italy
-
- Panico, Salvatore (författare)
- Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
-
- Eriksen, Anne Kirstine (författare)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark
-
- Tjønneland, Anne (författare)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark
-
- Aune, Dagfinn (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Nutrition, Bjørknes University College, Oslo, Norway; Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway
-
- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, Lyon, France
-
- Severi, Gianluca (författare)
- Centre for Epidemiology and Population Health, U1018, Generations and Health Team, Faculté de Médecine, Université Paris-Saclay, INSERM, Villejuif, France; Gustave Roussy, Villejuif, France
-
- Chajès, Véronique (författare)
- International Agency for Research on Cancer, Lyon, France
-
- Gunter, Marc J. (författare)
- International Agency for Research on Cancer, Lyon, France
-
visa färre...
-
(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
-
Ingår i: Clinical Gastroenterology and Hepatology. - : Elsevier. - 1542-3565 .- 1542-7714. ; 20:5, s. e1061-e1082
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
http://www.cghjourna...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background & Aims: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.Methods: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1–5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression.Results: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29–0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50–0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86–1.00) overall. Signature associations were stronger in male compared with female participants.Conclusions: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Colorectal Neoplasm
- Risk Factors
- Targeted Metabolomics
- World Cancer Research Fund/American Institute for Cancer Research Recommendations
- Oncology
- onkologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Rothwell, Joseph ...
-
Murphy, Neil
-
Bešević, Jelena
-
Kliemann, Nathal ...
-
Jenab, Mazda
-
Ferrari, Pietro
-
visa fler...
-
Achaintre, David
-
Gicquiau, Audrey
-
Vozar, Béatrice
-
Scalbert, August ...
-
Huybrechts, Inge
-
Freisling, Heinz
-
Prehn, Cornelia
-
Adamski, Jerzy
-
Cross, Amanda J.
-
Pala, Valeria Ma ...
-
Boutron-Ruault, ...
-
Dahm, Christina ...
-
Overvad, Kim
-
Gram, Inger Torh ...
-
Sandanger, Torkj ...
-
Skeie, Guri
-
Jakszyn, Paula
-
Tsilidis, Kostas ...
-
Aleksandrova, Kr ...
-
Schulze, Matthia ...
-
Hughes, David J.
-
van Guelpen, Bet ...
-
Bodén, Stina
-
Sánchez, Maria-J ...
-
Schmidt, Julie A ...
-
Katzke, Verena
-
Kühn, Tilman
-
Colorado-Yohar, ...
-
Tumino, Rosario
-
Bueno-de-Mesquit ...
-
Vineis, Paolo
-
Masala, Giovanna
-
Panico, Salvator ...
-
Eriksen, Anne Ki ...
-
Tjønneland, Anne
-
Aune, Dagfinn
-
Weiderpass, Elis ...
-
Severi, Gianluca
-
Chajès, Véroniqu ...
-
Gunter, Marc J.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Cancer och onkol ...
- Artiklar i publikationen
-
Clinical Gastroe ...
- Av lärosätet
-
Umeå universitet