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Matrix Metalloprote...
Matrix Metalloproteinase 8 Expression in a Tumour Predicts a Favourable Prognosis in Pancreatic Ductal Adenocarcinoma
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- Kaasinen, Mirjami (författare)
- Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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- Hagström, Jaana (författare)
- Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Department of Oral Pathology and Radiology, University of Turku, Turku, Finland; Translational Cancer Medicine Research Programme, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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- Mustonen, Harri (författare)
- Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Translational Cancer Medicine Research Programme, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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- Sorsa, Timo (författare)
- Karolinska Institutet
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- Sund, Malin (författare)
- Umeå universitet,Kirurgi,Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
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- Haglund, Caj (författare)
- Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Translational Cancer Medicine Research Programme, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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- Seppänen, Hanna (författare)
- Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Translational Cancer Medicine Research Programme, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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(creator_code:org_t)
- 2022-03-18
- 2022
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 23:6
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Pancreatic ductal adenocarcinoma (PDAC) is a significant cause of cancer-related death globally, and, despite improvements in diagnostics and treatment, survival remains poor. Matrix metalloproteinases (MMPs) are enzymes involved in stroma remodelling in inflammation and cancer. MMP-8 plays a varied prognostic role in cancers of the gastrointestinal tract. We examined the prognostic value of MMP-8 immunoexpression in tumour tissue and the amount of MMP-8-positive polymorphonuclear cells (PMNs) in PDAC and their association with immune responses using C-reactive protein (CRP) as a marker of systemic inflammation. Tumour samples from 141 PDAC patients undergoing surgery in 2002–2011 at the Department of Surgery, Helsinki University Hospital were stained immunohistochemically, for which we evaluated MMP-8 expression in cancer cells and the amount of MMP-8-positive PMNs. We assessed survival using the Kaplan–Meier analysis while uni-and multivariable analyses relied on the Cox proportional hazards model. A negative MMP-8 stain and elevated CRP level predicted a poor prognosis (hazard ratio [HR] = 6.95; 95% confidence interval (CI) 2.69–17.93; p < 0.001) compared to a positive stain and low CRP level (<10 mg/L). The absence of PMNs together with an elevated CRP level also predicted an unfavourable outcome (HR = 3.17; 95% CI 1.60–6.30; p = 0.001). MMP-8 expression in the tumour served as an independent positive prognostic factor (HR = 0.33; 95% CI 0.16–0.68; p = 0.003). Tumour MMP-8 expression and a low CRP level may predict a favourable outcome in PDAC with similar results for MMP-8-positive PMNs and low CRP levels. Tumoural MMP-8 expression represents an independent positive prognostic factor in PDAC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- C-reactive protein
- Matrix metalloproteinase 8
- Pancreatic cancer
- Polymorphonuclear cell
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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