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Endogenous Human Pr...
Endogenous Human Proteins Interfering with Amyloid Formation
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- Gharibyan, Anna (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Jayaweera, Sanduni Wasana (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Lehmann, Manuela (författare)
- Umeå universitet,Avdelningen för hållbar hälsa
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- Anan, Intissar (författare)
- Umeå universitet,Avdelningen för medicin
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- Olofsson, Anders, 1970- (författare)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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(creator_code:org_t)
- 2022-03-14
- 2022
- Engelska.
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Ingår i: Biomolecules. - : MDPI. - 2218-273X. ; 12:3
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Amyloid formation is a pathological process associated with a wide range of degenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and diabetes mellitus type 2. During disease progression, abnormal accumulation and deposition of proteinaceous material are accompanied by tissue degradation, inflammation, and dysfunction. Agents that can interfere with the process of amyloid formation or target already formed amyloid assemblies are consequently of therapeutic interest. In this context, a few endogenous proteins have been associated with an anti-amyloidogenic activity. Here, we review the properties of transthyretin, apolipoprotein E, clusterin, and BRICHOS protein domain which all effectively interfere with amyloid in vitro, as well as displaying a clinical impact in humans or animal models. Their involvement in the amyloid formation process is discussed, which may aid and inspire new strategies for therapeutic interventions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Alpha-synuclein
- Amyloid inhibition
- Amyloid-beta
- Apolipoprotein E
- BRICHOS
- Clusterin
- Endogenous proteins
- IAPP
- Transthyretin
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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