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Fluorescent Molecul...
Fluorescent Molecularly Imprinted Polymer Layers against Sialic Acid on Silica-Coated Polystyrene Cores — Assessment of the Binding Behavior to Cancer Cells
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- Beyer, Sarah, 1982- (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV)
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- Kimani, Martha (författare)
- Chemical and Optical Sensing Division, Bundesanstalt für Materialforschung und -prüfung (BAM), Richard-Willstätter Straße 11, 12489 Berlin, Germany
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- Zhang, Yuecheng (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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- Verhassel, Alejandra (författare)
- Institute of Biomedicine, University of Turku, 20520 Turku, Finland; FICAN West Cancer Centre, Turku University Hospital, 20520 Turku, Finland
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- Sternbæk, Louise (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Phase Holographic Imaging AB, SE-223 63 Lund, Sweden
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- Wang, Tianyan (författare)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden
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- Persson, Jenny L., Professor (författare)
- Malmö universitet,Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Biomedical Sciences, Faculty of Health and Society, Malmö University, Malmö, Sweden; Biofilms-Research Center for Biointerfaces, Malmö University, Malmö, Sweden,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces,Department of Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden
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- Härkönen, Pirkko (författare)
- Institute of Biomedicine, University of Turku, 20520 Turku, Finland; FICAN West Cancer Centre, Turku University Hospital, 20520 Turku, Finland
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- Johansson, Emil, 1985- (författare)
- Umeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR),Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden; Umeå Centre for Microbial Research, Umeå University, SE-901 87 Umeå, Sweden
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- Caraballo, Remi (författare)
- Umeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR),Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden; Umeå Centre for Microbial Research, Umeå University, SE-901 87 Umeå, Sweden
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- Elofsson, Mikael (författare)
- Umeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR),Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden; Umeå Centre for Microbial Research, Umeå University, SE-901 87 Umeå, Sweden
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- Gawlitza, Kornelia (författare)
- Chemical and Optical Sensing Division, Bundesanstalt für Materialforschung und -prüfung (BAM), Richard-Willstätter Straße 11, 12489 Berlin, Germany
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- Rurack, Knut (författare)
- Chemical and Optical Sensing Division, Bundesanstalt für Materialforschung und -prüfung (BAM), Richard-Willstätter Straße 11, 12489 Berlin, Germany
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- Ohlsson, Lars (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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- El-Schich, Zahra (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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- Gjörloff Wingren, Anette (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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- Stollenwerk, Maria M, 1959- (författare)
- Malmö universitet,Institutionen för biomedicinsk vetenskap (BMV),Biofilms Research Center for Biointerfaces
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(creator_code:org_t)
- 2022-04-08
- 2022
- Engelska.
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Ingår i: Cancers. - : MDPI. - 2072-6694. ; 14:8
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://mau.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Sialic acid (SA) is a monosaccharide usually linked to the terminus of glycan chains on the cell surface. It plays a crucial role in many biological processes, and hypersialylation is a common feature in cancer. Lectins are widely used to analyze the cell surface expression of SA. However, these protein molecules are usually expensive and easily denatured, which calls for the development of alternative glycan-specific receptors and cell imaging technologies. In this study, SA-imprinted fluorescent core-shell molecularly imprinted polymer particles (SA-MIPs) were employed to recognize SA on the cell surface of cancer cell lines. The SA-MIPs improved suspensibility and scattering properties compared with previously used core-shell SA-MIPs. Although SA-imprinting was performed using SA without preference for the α2,3-and α2,6-SA forms, we screened the cancer cell lines analyzed using the lectins Maackia Amurensis Lectin I (MAL I, α2,3-SA) and Sambucus Nigra Lectin (SNA, α2,6-SA). Our results show that the selected cancer cell lines in this study presented a varied binding behavior with the SA-MIPs. The binding pattern of the lectins was also demonstrated. Moreover, two different pentavalent SA conjugates were used to inhibit the binding of the SA-MIPs to breast, skin, and lung cancer cell lines, demonstrating the specificity of the SA-MIPs in both flow cytometry and confocal fluorescence microscopy. We concluded that the synthesized SA-MIPs might be a powerful future tool in the diagnostic analysis of various cancer cells.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- cancer
- imprinting
- molecularly imprinted polymers
- SA conjugates
- sialic acid
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
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Cancers
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
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Beyer, Sarah, 19 ...
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Kimani, Martha
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Zhang, Yuecheng
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Verhassel, Aleja ...
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Sternbæk, Louise
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Wang, Tianyan
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visa fler...
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Persson, Jenny L ...
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Härkönen, Pirkko
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Johansson, Emil, ...
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Caraballo, Remi
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Elofsson, Mikael
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Gawlitza, Kornel ...
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Rurack, Knut
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Ohlsson, Lars
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El-Schich, Zahra
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Gjörloff Wingren ...
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Stollenwerk, Mar ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Cell och molekyl ...
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Biokemi och mole ...
- Artiklar i publikationen
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Cancers
- Av lärosätet
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Umeå universitet
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Malmö universitet