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Evolution of biomar...
Evolution of biomarker research in autoimmunity conditions for health professionals and clinical practice
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- Silverstein, Arthur (författare)
- Department of the History of Medicine, Johns Hopkins University, MD, Baltimore, United States
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- Dudaev, Anton (författare)
- MGUPP, Moscow, Russian Federation
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- Studneva, Maria (författare)
- MGUPP, Moscow, Russian Federation; EPMA (European Association for Predictive, Preventive and Personalized Medicine), Brussels, Belgium
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- Aitken, John (författare)
- Otakaro Pathways, Christchurch, New Zealand
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- Blokh, Sofya (författare)
- Filatov's Moscow Clinical Pediatric Hospital, Moscow, Russian Federation
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- Miller, Andrew David (författare)
- Mendel University and Veterinary Research Institute, Brno, Czech Republic
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- Tanasova, Sofia (författare)
- A.I. Evdokimov Moscow State University of Medicine & Dentistry, Moscow, Russian Federation
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- Rose, Noel (författare)
- Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States
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- Ryals, John (författare)
- Mathematics Department at Central Georgia Technical College, GA, Warner Robins, United States
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- Borchers, Christoph (författare)
- Lady Davis Institute, Segal Cancer Proteomics Centre, McGill University, QC, Montreal, Canada
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- Nordström, Anders (författare)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Moiseyakh, Marina (författare)
- MGUPP, Moscow, Russian Federation
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- Herrera, Arturo Solís (författare)
- University of Florida, FL, Gainesville, United States
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- Skomorohov, Nikita (författare)
- MGUPP, Moscow, Russian Federation
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- Marshall, Trevor (författare)
- University of Adelaide, SA, Adelaide, Australia; Murdoch University, WA, Murdoch, Australia; The Autoimmunity Research Foundation, CA, Thousand Oaks, United States
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- Wu, Alan (författare)
- San Francisco General Hospital, CA, San Francisco, United States; UCSF, CA, San Francisco, United States
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- Cheng, R. Holland (författare)
- College of Biological Sciences, UC Davis, CA, Davis, United States
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- Syzko, Ksenia (författare)
- MGUPP, Moscow, Russian Federation
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- Cotter, Philip D. (författare)
- UCSF, CA, San Francisco, United States; ResearchDx and PacificDx, CA, Irvine, United States
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- Podzyuban, Marianna (författare)
- MGUPP, Moscow, Russian Federation
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- Thilly, William (författare)
- Massachusetts Institute of Technology, MIT, MA, Cambridge, United States
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- Smith, Paul David (författare)
- Newberry College, SC, Newberry, United States
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- Barach, Paul (författare)
- Wayne State University, IL, Detroit, United States
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- Bouri, Khaled (författare)
- Georgetown University, DC, Washington, United States
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- Schoenfeld, Yehuda (författare)
- Sheba Medical Center in Tel Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
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- Matsuura, Eiji (författare)
- Neutron Therapy Research, Center Collaborative Research Center for OMIC & Department of Cell Chemistry, Okayama University, Okayama, Japan
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- Medvedeva, Veronika (författare)
- I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
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- Shmulevich, Ilya (författare)
- Institute of Systems Biology (ISB), WA, Seattle, United States
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- Cheng, Liang (författare)
- Genitourinary Pathology Service, The Urologic Pathology Fellowship, and Molecular Diagnostics and Molecular Pathology Laboratories, Indiana University School of Medicine, IN, Indianapolis, United States
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- Seegers, Paul (författare)
- Stichting PALGA (Pathologisch Anatomisch Landelijk Geautomatiseerd Archief), Houten, Netherlands
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- Khotskaya, Yekaterina (författare)
- Clinical Decision Support Management, The Curematch, Inc, CA, San Diego, United States
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- Flaherty, Keith (författare)
- Harvard Medical School, MA, Boston, United States; Mass General Cancer Center, Massachusetts General Hospital, MA, Boston, United States
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- Dooley, Steven (författare)
- Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany
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- Sorenson, Eric J. (författare)
- Mayo Clinic, MN, Rochester, United States
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- Ross, Michael (författare)
- UCLA Medical Center Obstetrics & Gynecology, CA, Los Angeles, United States
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- Suchkov, Sergey (författare)
- MGUPP, Moscow, Russian Federation; EPMA (European Association for Predictive, Preventive and Personalized Medicine), Brussels, Belgium; A.I. Evdokimov Moscow State University of Medicine & Dentistry, Moscow, Russian Federation; ISPM (International Society for Personalized Medicine), Tokyo, Japan; PMC (Personalized Medicine Coalition), DC, Washington, United States; New York Academy of Sciences, NY, New York, United States; Association for Medical Education in Europe (AMEE), Dundee, United Kingdom
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Precision medicine. - : Elsevier. - 9780323997843 ; , s. 219-276
- Relaterad länk:
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https://ebookcentral...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Medical abzymology has made a great contribution to the development of general autoimmunity theory: it has put the autoantibodies (Ab) as the key brick of the theory to the level of physiological functionality by providing such Ab with the ability to catalyze and mediate direct and independent cytotoxic effect on cellular and molecular targets. Natural catalytic autoantibodies (abzymes) while being a pool of canonical Abs and possessing catalytic activity belong to the new group of physiologically active substances whose features and properties are evolutionary consolidated in one functionally active biomolecule. Therefore, further studies on Ab-mediated autoAg degradation and other targeted Ab-mediated proteolysis may provide biomarkers of newer generations and thus a supplementary tool for assessing the disease progression and predicting disability of the patients and persons at risks. This chapter is a summary of current knowledge and prognostic perspectives toward catalytic Abs in autoimmunity and thus some autoimmune clinical cases, their role in pathogenesis, and the exploitation of both whole molecules and their constituent parts in developing highly effective targeted drugs of the future to come, and thus the therapeutic protocols being individualized.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Biomarker
- Multimarker-based companion diagnostics
- Multiple sclerosis
- Next-generation biomarker
- Personalized and precision medicine
- Protein microarrays
- Rheumatoid arthritis
- Targeted therapy
- Western blotting
Publikations- och innehållstyp
- ref (ämneskategori)
- kap (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Silverstein, Art ...
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Dudaev, Anton
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Studneva, Maria
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Aitken, John
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Blokh, Sofya
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Miller, Andrew D ...
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visa fler...
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Tanasova, Sofia
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Rose, Noel
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Ryals, John
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Borchers, Christ ...
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Nordström, Ander ...
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Moiseyakh, Marin ...
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Herrera, Arturo ...
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Skomorohov, Niki ...
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Marshall, Trevor
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Wu, Alan
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Cheng, R. Hollan ...
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Syzko, Ksenia
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Cotter, Philip D ...
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Podzyuban, Maria ...
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Thilly, William
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Smith, Paul Davi ...
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Barach, Paul
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Bouri, Khaled
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Schoenfeld, Yehu ...
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Matsuura, Eiji
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Medvedeva, Veron ...
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Shmulevich, Ilya
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Cheng, Liang
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Seegers, Paul
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Khotskaya, Yekat ...
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Flaherty, Keith
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Dooley, Steven
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Sorenson, Eric J ...
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Ross, Michael
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Suchkov, Sergey
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- MEDICIN OCH HÄLSOVETENSKAP
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och Cell och molekyl ...
- Artiklar i publikationen
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Precision medici ...
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Umeå universitet