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Interaction of leisure-time physical activity with body mass index on the risk of obesity-related cancers : A pooled study

Sun, Ming (författare)
Lund University,Lunds universitet,Registerbaserad epidemiologi,Forskargrupper vid Lunds universitet,Biomarkörer och Epi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Registerbaserad epidemiologi - Stocks,Institutionen för translationell medicin,Register-based epidemiology,Lund University Research Groups,Biomarkers and epidemiology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Translational Medicine,Lund Univ, Dept Clin Sci Lund, Barngatan 4, SE-22185 Lund, Sweden
Bjørge, Tone (författare)
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Cancer Registry of Norway, Oslo, Norway,Cancer Registry of Norway, Institute of Population-Based Cancer Research,Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Canc Registry Norway, Oslo, Norway
Teleka, Stanley (författare)
Uppsala universitet,Uppsala University,Lund University,Lunds universitet,Registerbaserad epidemiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Biomarkörer och Epi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Register-based epidemiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Biomarkers and epidemiology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Medicinsk epidemiologi,Lund Univ, Dept Clin Sci Lund, Barngatan 4, SE-22185 Lund, Sweden
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Engeland, Anders (författare)
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Division of Mental and Physical Health, Norwegian Institute of Public Health, Bergen, Norway,Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway.;Norwegian Inst Publ Hlth, Div Mental & Phys Hlth, Bergen, Norway
Wennberg, Patrik, 1972- (författare)
Umeå University,Umeå universitet,Allmänmedicin,Umeå Univ, Dept Publ Hlth & Clin Med, Umeå, Sweden
Häggström, Christel (författare)
Uppsala universitet,Uppsala University,Umeå University,Umeå universitet,Avdelningen för medicin,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden,Endokrinkirurgi,Umeå Univ, Dept Publ Hlth & Clin Med, Northern Register Ctr, Umeå, Sweden
Stocks, Tanja (författare)
Lund University,Lunds universitet,Registerbaserad epidemiologi,Forskargrupper vid Lunds universitet,Biomarkörer och Epi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Registerbaserad epidemiologi - Stocks,Institutionen för translationell medicin,Register-based epidemiology,Lund University Research Groups,Biomarkers and epidemiology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Translational Medicine,Lund Univ, Dept Clin Sci Lund, Barngatan 4, SE-22185 Lund, Sweden
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 (creator_code:org_t)
2022-04-07
2022
Engelska.
Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 151:6, s. 859-868
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
http://dx.doi.org/10... (free)
https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
https://lup.lub.lu.s...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Physical activity (PA) has been associated with a lower risk of some obesity-related cancers, but the combined association and interaction of PA and body weight on obesity-related cancer risk is less clear. We examined the association of leisure-time PA (high/low) and its combination with body mass index (BMI, <25 [low]/≥25 [high] kg/m2) on obesity-related cancer risk in 570 021 individuals, aged 43 years on average at baseline, in five Scandinavian cohorts. We used Cox regression to calculate hazard ratios of obesity-related cancers (n = 19 074) and assessed multiplicative and additive interactions between PA and BMI on risk. High leisure-time PA, recorded in 19% of the individuals, was associated with a 7% (95% confidence interval [CI] 4%-10%) lower risk of any obesity-related cancer compared to low PA, with similar associations amongst individuals with a low and a high BMI (6% [1%-11%] and 7% [2%-11%]). High PA was also associated with decreased risks of renal cell (11% [9%-31%]) and colon cancer (9% [2%-16%]). When high PA and low BMI were combined, the relative risk reduction for all obesity-related cancers was 24% (95% CI 20%-28%); endometrial cancer, 47% (35%-57%); renal cell cancer, 39% (27%-51%); colon cancer, 27% (19%-35%); multiple myeloma, 23% (2%-40%) and pancreatic cancer, 21% (4%-35%), compared to low PA-high BMI. There were no additive or multiplicative interactions between PA and BMI on risk. The result of our study suggests a reduced risk of obesity-related cancer by leisure-time PA in both normal weight and overweight individuals, which further decreased for PA and normal weight combined.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

body mass index
interaction
leisure-time physical activity
obesity-related cancer
body mass index
interaction
leisure-time physical activity
obesity-related cancer

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